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Lip cancer

MedGen UID:
57548
•Concept ID:
C0153340
•
Neoplastic Process
Synonyms: Cancer of Lip; Cancer of the Lip; Cancer, Lip; Cancers, Lip; Lip Cancer; Lip Cancers
SNOMED CT: CA - Cancer of lip (363348004); Cancer of lip (363348004); Malignant tumor of lip (363348004)
 
Monarch Initiative: MONDO:0006834

Definition

A primary or metastatic malignant neoplasm involving the lip. [from NCI]

Professional guidelines

PubMed

Interstitial Brachytherapy for Lip Cancer: Technical Aspects to Individualize Treatment Approach and Optimize Outcomes.
Merfeld EC, Witek ME, Francis DM, Burr AR, Wallace CR, Kuczmarska-Haas A, Lamichhane N, Kimple RJ, Glazer TA, Wieland AM, McCulloch TM, Hartig GK, Harari PM
Pract Radiat Oncol 2023 Jul-Aug;13(4):340-345. Epub 2023 Jan 25 doi: 10.1016/j.prro.2023.01.004. PMID: 36709044Free PMC Article
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
Lip cancer: Reconsidering the at-risk patients with pathological assessment.
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Cancer and UV-radiation.
Osterlind A
Pharmacol Toxicol 1993;72 Suppl 1:67-8. doi: 10.1111/j.1600-0773.1993.tb01672.x. PMID: 8474993

Diagnosis

Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Brachytherapy in lip cancer.
Rovirosa-Casino A, Planas-Toledano I, Ferre-Jorge J, Oliva-Díez JM, Conill-Llobet C, Arenas-Prat M
Med Oral Patol Oral Cir Bucal 2006 May 1;11(3):E223-9. PMID: 16648757

Therapy

Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Cancer and UV-radiation.
Osterlind A
Pharmacol Toxicol 1993;72 Suppl 1:67-8. doi: 10.1111/j.1600-0773.1993.tb01672.x. PMID: 8474993

Prognosis

Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Brachytherapy in lip cancer.
Rovirosa-Casino A, Planas-Toledano I, Ferre-Jorge J, Oliva-Díez JM, Conill-Llobet C, Arenas-Prat M
Med Oral Patol Oral Cir Bucal 2006 May 1;11(3):E223-9. PMID: 16648757

Clinical prediction guides

Occupational variation in the incidence of lip cancer in the Nordic countries.
Mroueh R, Carpén T, Mäkitie A, Hansen J, Heikkinen S, Lynge E, Martinsen JI, Selander J, Mehlum IS, Torfadottir JE, Salo T, Pukkala E
Acta Oncol 2023 Jun;62(6):541-549. Epub 2023 Jun 19 doi: 10.1080/0284186X.2023.2224053. PMID: 37337140
A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360

Recent systematic reviews

Lip Cancer: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration A Systematic Review of 19,213 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5).
Milano AF
J Insur Med 2023 Mar 7;49(4):1-12. doi: 10.17849/insm-49-4-1-12.1. PMID: 36883809
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis.
Varela-Centelles P, Gonzalez-Moles MÁ, Seoane-Romero J, Leira-Feijoo Y, Takkouche B, Seoane-Romero JM
Oral Dis 2022 Jan;28(1):57-65. Epub 2020 Oct 5 doi: 10.1111/odi.13643. PMID: 32945581
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis.
Santana T, Matuck B, Tenório JR, Braga MM
Med Oral Patol Oral Cir Bucal 2020 Jan 1;25(1):e106-e116. doi: 10.4317/medoral.23223. PMID: 31880283Free PMC Article
Malignant transformation of actinic cheilitis: A systematic review of observational studies.
Dancyger A, Heard V, Huang B, Suley C, Tang D, Ariyawardana A
J Investig Clin Dent 2018 Nov;9(4):e12343. Epub 2018 Jun 4 doi: 10.1111/jicd.12343. PMID: 29863311

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