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Incisional hernia

MedGen UID:
505711
Concept ID:
CN004317
Finding
Synonyms: Recurrent abdominal hernia
 
HPO: HP:0004872

Definition

An abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGIncisional hernia

Conditions with this feature

Marfan's syndrome
MedGen UID:
44287
Concept ID:
C0024796
Disease or Syndrome
Marfan syndrome is a systemic disorder of connective tissue with a high degree of clinical variability. Cardinal manifestations involve the ocular, skeletal, and cardiovascular systems. FBN1 pathogenic variants associate with a broad phenotypic continuum, ranging from isolated features of Marfan syndrome to neonatal presentation of severe and rapidly progressive disease in multiple organ systems. Myopia is the most common ocular feature; displacement of the lens from the center of the pupil, seen in approximately 60% of affected individuals, is a hallmark feature. People with Marfan syndrome are at increased risk for retinal detachment, glaucoma, and early cataract formation. The skeletal system involvement is characterized by bone overgrowth and joint laxity. The extremities are disproportionately long for the size of the trunk (dolichostenomelia). Overgrowth of the ribs can push the sternum in (pectus excavatum) or out (pectus carinatum). Scoliosis is common and can be mild or severe and progressive. The major sources of morbidity and early mortality in the Marfan syndrome relate to the cardiovascular system. Cardiovascular manifestations include dilatation of the aorta at the level of the sinuses of Valsalva, a predisposition for aortic tear and rupture, mitral valve prolapse with or without regurgitation, tricuspid valve prolapse, and enlargement of the proximal pulmonary artery. With proper management, the life expectancy of someone with Marfan syndrome approximates that of the general population.

Recent clinical studies

Etiology

Aquina CT, Rickles AS, Probst CP, Kelly KN, Deeb AP, Monson JR, Fleming FJ; Muscle and Adiposity Research Consortium (MARC)
Dis Colon Rectum 2015 Feb;58(2):220-7. doi: 10.1097/DCR.0000000000000261. PMID: 25585081
Stey AM, Russell MM, Hall BL, Lin A, Gibbons MM, Lawson EH, Zingmond DS, Ko CY
J Am Coll Surg 2015 Mar;220(3):313-322.e2. Epub 2014 Nov 21 doi: 10.1016/j.jamcollsurg.2014.11.011. [Epub ahead of print] PMID: 25542281
Navaratnam AV, Ariyaratnam R, Smart NJ, Parker M, Motson RW, Arulampalam TH
Ann R Coll Surg Engl 2015 Jan;97(1):17-21. doi: 10.1308/003588414X14055925058274. PMID: 25519260
de Goede B, Eker HH, Klitsie PJ, van Kempen BJ, Polak WG, Hop WC, Metselaar HJ, Tilanus HW, Lange JF, Kazemier G
Clin Transplant 2014 Jul;28(7):829-36. Epub 2014 Jun 12 doi: 10.1111/ctr.12386. [Epub ahead of print] PMID: 24806311
Heller A, Westphal SE, Bartsch P, Haase M, Mertens PR
Int Urol Nephrol 2014 Jun;46(6):1175-81. doi: 10.1007/s11255-013-0565-1. [Epub ahead of print] PMID: 24078009

Diagnosis

Aquina CT, Rickles AS, Probst CP, Kelly KN, Deeb AP, Monson JR, Fleming FJ; Muscle and Adiposity Research Consortium (MARC)
Dis Colon Rectum 2015 Feb;58(2):220-7. doi: 10.1097/DCR.0000000000000261. PMID: 25585081
Stey AM, Russell MM, Hall BL, Lin A, Gibbons MM, Lawson EH, Zingmond DS, Ko CY
J Am Coll Surg 2015 Mar;220(3):313-322.e2. Epub 2014 Nov 21 doi: 10.1016/j.jamcollsurg.2014.11.011. [Epub ahead of print] PMID: 25542281
Nakayama M, Yoshimatsu K, Yokomizo H, Yano Y, Okayama S, Satake M, Matsumoto A, Fujimoto T, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Naritaka Y
Hepatogastroenterology 2014 Jul-Aug;61(133):1220-3. PMID: 25436286
de Goede B, Eker HH, Klitsie PJ, van Kempen BJ, Polak WG, Hop WC, Metselaar HJ, Tilanus HW, Lange JF, Kazemier G
Clin Transplant 2014 Jul;28(7):829-36. Epub 2014 Jun 12 doi: 10.1111/ctr.12386. [Epub ahead of print] PMID: 24806311
Carlsson SV, Ehdaie B, Atoria CL, Elkin EB, Eastham JA
J Urol 2013 Nov;190(5):1757-62. Epub 2013 May 18 doi: 10.1016/j.juro.2013.05.036. [Epub ahead of print] PMID: 23688847Free PMC Article

Therapy

Benlice C, Stocchi L, Costedio M, Gorgun E, Hull T, Kessler H, Remzi FH
Dis Colon Rectum 2015 Mar;58(3):314-20. doi: 10.1097/DCR.0000000000000287. PMID: 25664709
Navaratnam AV, Ariyaratnam R, Smart NJ, Parker M, Motson RW, Arulampalam TH
Ann R Coll Surg Engl 2015 Jan;97(1):17-21. doi: 10.1308/003588414X14055925058274. PMID: 25519260
de Goede B, Eker HH, Klitsie PJ, van Kempen BJ, Polak WG, Hop WC, Metselaar HJ, Tilanus HW, Lange JF, Kazemier G
Clin Transplant 2014 Jul;28(7):829-36. Epub 2014 Jun 12 doi: 10.1111/ctr.12386. [Epub ahead of print] PMID: 24806311
Fink C, Baumann P, Wente MN, Knebel P, Bruckner T, Ulrich A, Werner J, Büchler MW, Diener MK
Br J Surg 2014 Jan;101(2):51-4. Epub 2013 Nov 26 doi: 10.1002/bjs.9364. [Epub ahead of print] PMID: 24281948
Nieuwenhuizen J, Eker HH, Timmermans L, Hop WC, Kleinrensink GJ, Jeekel J, Lange JF; PRIMA Trialist Group
BMC Surg 2013 Oct 28;13:48. doi: 10.1186/1471-2482-13-48. [Epub ahead of print] PMID: 24499111Free PMC Article

Prognosis

Benlice C, Stocchi L, Costedio M, Gorgun E, Hull T, Kessler H, Remzi FH
Dis Colon Rectum 2015 Mar;58(3):314-20. doi: 10.1097/DCR.0000000000000287. PMID: 25664709
Stey AM, Russell MM, Hall BL, Lin A, Gibbons MM, Lawson EH, Zingmond DS, Ko CY
J Am Coll Surg 2015 Mar;220(3):313-322.e2. Epub 2014 Nov 21 doi: 10.1016/j.jamcollsurg.2014.11.011. [Epub ahead of print] PMID: 25542281
de Goede B, Eker HH, Klitsie PJ, van Kempen BJ, Polak WG, Hop WC, Metselaar HJ, Tilanus HW, Lange JF, Kazemier G
Clin Transplant 2014 Jul;28(7):829-36. Epub 2014 Jun 12 doi: 10.1111/ctr.12386. [Epub ahead of print] PMID: 24806311
Fink C, Baumann P, Wente MN, Knebel P, Bruckner T, Ulrich A, Werner J, Büchler MW, Diener MK
Br J Surg 2014 Jan;101(2):51-4. Epub 2013 Nov 26 doi: 10.1002/bjs.9364. [Epub ahead of print] PMID: 24281948
Nieuwenhuizen J, Eker HH, Timmermans L, Hop WC, Kleinrensink GJ, Jeekel J, Lange JF; PRIMA Trialist Group
BMC Surg 2013 Oct 28;13:48. doi: 10.1186/1471-2482-13-48. [Epub ahead of print] PMID: 24499111Free PMC Article

Clinical prediction guides

Henriksen NA, Mortensen JH, Sorensen LT, Bay-Jensen AC, Ågren MS, Jorgensen LN, Karsdal MA
Surgery 2015 Feb;157(2):312-21. doi: 10.1016/j.surg.2014.09.006. PMID: 25616945
Abet E, Duchalais E, Denimal F, de Kerviler B, Jean MH, Brau-Weber AG, Comy M; Groupe d'étude et de recherche en chirurgie coelioscopique de l'Ouest (GRECCO, Western laparoscopic study, research group)
J Visc Surg 2014 Apr;151(2):103-6. Epub 2014 Feb 28 doi: 10.1016/j.jviscsurg.2014.01.012. [Epub ahead of print] PMID: 24582727
Liu DS, Banham E, Yellapu S
World J Surg 2013 Sep;37(9):2039-45. doi: 10.1007/s00268-013-2109-3. PMID: 23716028
Bhangu A, Fitzgerald JE, Singh P, Battersby N, Marriott P, Pinkney T
Hernia 2013 Aug;17(4):445-55. Epub 2013 May 28 doi: 10.1007/s10029-013-1119-2. [Epub ahead of print] PMID: 23712289
Eker HH, Hansson BM, Buunen M, Janssen IM, Pierik RE, Hop WC, Bonjer HJ, Jeekel J, Lange JF
JAMA Surg 2013 Mar;148(3):259-63. doi: 10.1001/jamasurg.2013.1466. PMID: 23552714

Recent systematic reviews

Deerenberg EB, Timmermans L, Hogerzeil DP, Slieker JC, Eilers PH, Jeekel J, Lange JF
Hernia 2015 Feb;19(1):89-101. Epub 2014 Nov 8 doi: 10.1007/s10029-014-1321-x. [Epub ahead of print] PMID: 25380560
Jensen KK, Henriksen NA, Harling H
Am J Surg 2014 Sep;208(3):485-93. Epub 2014 Jun 12 doi: 10.1016/j.amjsurg.2014.04.004. [Epub ahead of print] PMID: 25017051
Fink C, Baumann P, Wente MN, Knebel P, Bruckner T, Ulrich A, Werner J, Büchler MW, Diener MK
Br J Surg 2014 Jan;101(2):51-4. Epub 2013 Nov 26 doi: 10.1002/bjs.9364. [Epub ahead of print] PMID: 24281948
Gurusamy KS, Allen VB
Cochrane Database Syst Rev 2013 Dec 17;12:CD005570. doi: 10.1002/14651858.CD005570.pub4. PMID: 24346957
Bhangu A, Fitzgerald JE, Singh P, Battersby N, Marriott P, Pinkney T
Hernia 2013 Aug;17(4):445-55. Epub 2013 May 28 doi: 10.1007/s10029-013-1119-2. [Epub ahead of print] PMID: 23712289

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