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Colonic L-cell glucagon-like peptide producing tumor

MedGen UID:
475772
•Concept ID:
C3274139
•
Neoplastic Process
Synonyms: Colon L-Cell Glucagon-Like Peptide-Producing NET; colon L-cell glucagon-like peptide-producing NET; Colon L-Cell Glucagon-Like Peptide-Producing Neuroendocrine Tumor; colon L-cell glucagon-like peptide-producing neuroendocrine tumor; colon L-cell glucagon-like peptide-producing neuroendocrine tumour; colonic L-cell glucagon-like peptide producing tumor; Colonic L-Cell Glucagon-Like Peptide-Producing Neuroendocrine Tumor; colonic L-cell glucagon-like peptide-producing neuroendocrine tumor; colonic L-cell glucagon-like peptide-producing neuroendocrine tumour; L-cell glucagon-like peptide-producing neuroendocrine tumor of colon; L-cell glucagon-like peptide-producing neuroendocrine tumour of colon
 
Monarch Initiative: MONDO:0004210

Definition

A neuroendocrine tumor that arises from the colon and produces glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColonic L-cell glucagon-like peptide producing tumor

Recent clinical studies

Etiology

Abundance and turnover of GLP-1 producing L-cells in ileal mucosa are not different in patients with and without type 2 diabetes.
Kampmann K, Ueberberg S, Menge BA, Breuer TG, Uhl W, Tannapfel A, Meier JJ
Metabolism 2016 Mar;65(3):84-91. Epub 2015 Oct 23 doi: 10.1016/j.metabol.2015.10.025. PMID: 26892519
Why diabetes patients are more prone to the development of colon cancer?
Jin T
Med Hypotheses 2008 Aug;71(2):241-4. Epub 2008 May 5 doi: 10.1016/j.mehy.2008.03.025. PMID: 18456417

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