U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Colorectal neuroendocrine tumor G1

MedGen UID:
474244
•Concept ID:
C3272611
•
Neoplastic Process
Synonyms: Colorectal Carcinoid Tumor; colorectal carcinoid tumor; colorectal carcinoid tumour; Colorectal NET G1; colorectal NET G1; Colorectal Neuroendocrine Tumor G1; colorectal neuroendocrine tumor G1; colorectum carcinoid tumor; colorectum carcinoid tumour; colorectum NET G1; colorectum neuroendocrine neoplasm G1; colorectum neuroendocrine tumor, well differentiated, low grade; grade 1 neuroendocrine neoplasm of colorectum; Large Intestinal Neuroendocrine Tumor G1; large intestinal neuroendocrine tumor G1; large intestinal neuroendocrine tumour G1
 
Monarch Initiative: MONDO:0006162

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the colon or rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Professional guidelines

PubMed

Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases.
Mauri G, Rossi D, Frassoni S, Bonomo G, Camisassi N, Della Vigna P, Bagnardi V, Maiettini D, Varano GM, Zampino MG, Orsi F
Cardiovasc Intervent Radiol 2022 Jun;45(6):770-779. Epub 2022 Jan 14 doi: 10.1007/s00270-021-03039-1. PMID: 35029709
Evaluation of radical surgical treatment in the management of 58 locally advanced rectal neuroendocrine neoplasms, one multicenter retrospective study.
Wang Z, Liu Z, Wen Z, Li R, An K, Mei S, Chen J, Shen H, Li J, Zhao F, Wei F, Xiao T, Liu Q
Eur J Surg Oncol 2021 Dec;47(12):3166-3174. Epub 2021 Jul 15 doi: 10.1016/j.ejso.2021.07.010. PMID: 34294465

Recent clinical studies

Etiology

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Detection of NRG1 Gene Fusions in Solid Tumors.
Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV
Clin Cancer Res 2019 Aug 15;25(16):4966-4972. Epub 2019 Apr 15 doi: 10.1158/1078-0432.CCR-19-0160. PMID: 30988082Free PMC Article
BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma.
Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A
Int J Cancer 2019 Mar 15;144(6):1379-1390. Epub 2018 Oct 30 doi: 10.1002/ijc.31828. PMID: 30144031
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need.
Ramage JK, Valle JW, Nieveen van Dijkum EJM, Sundin A, Pascher A, Couvelard A, Kloeppel G; the ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):45-53. Epub 2018 Sep 16 doi: 10.1159/000493767. PMID: 30219817
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Therapy

Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.
Khushalani NI, Ott PA, Ferris RL, Cascone T, Schadendorf D, Le DT, Sharma MR, Barlesi F, Sharfman W, Luke JJ, Melero I, Lathers D, Neely J, Suryawanshi S, Sanyal A, Holloway JL, Suryawanshi R, Ely S, Segal NH
J Immunother Cancer 2024 Mar 7;12(3) doi: 10.1136/jitc-2023-007364. PMID: 38458639Free PMC Article
BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma.
Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A
Int J Cancer 2019 Mar 15;144(6):1379-1390. Epub 2018 Oct 30 doi: 10.1002/ijc.31828. PMID: 30144031
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.
King AJ, Arnone MR, Bleam MR, Moss KG, Yang J, Fedorowicz KE, Smitheman KN, Erhardt JA, Hughes-Earle A, Kane-Carson LS, Sinnamon RH, Qi H, Rheault TR, Uehling DE, Laquerre SG
PLoS One 2013;8(7):e67583. Epub 2013 Jul 3 doi: 10.1371/journal.pone.0067583. PMID: 23844038Free PMC Article
A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo.
Kulcsár G, Gaál D, Kulcsár PI, Schulcz Á, Czömpöly T
Int J Cancer 2013 Mar 1;132(5):1213-21. Epub 2012 Aug 24 doi: 10.1002/ijc.27756. PMID: 22858865Free PMC Article

Prognosis

Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.
Capurso G, Gaujoux S, Pescatori LC, Panzuto F, Panis Y, Pilozzi E, Terris B, de Mestier L, Prat F, Rinzivillo M, Coriat R, Coulevard A, Delle Fave G, Ruszniewski P
Dig Liver Dis 2019 Dec;51(12):1725-1730. Epub 2019 Aug 9 doi: 10.1016/j.dld.2019.07.011. PMID: 31405587
BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma.
Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A
Int J Cancer 2019 Mar 15;144(6):1379-1390. Epub 2018 Oct 30 doi: 10.1002/ijc.31828. PMID: 30144031
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Clinical prediction guides

Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.
Khushalani NI, Ott PA, Ferris RL, Cascone T, Schadendorf D, Le DT, Sharma MR, Barlesi F, Sharfman W, Luke JJ, Melero I, Lathers D, Neely J, Suryawanshi S, Sanyal A, Holloway JL, Suryawanshi R, Ely S, Segal NH
J Immunother Cancer 2024 Mar 7;12(3) doi: 10.1136/jitc-2023-007364. PMID: 38458639Free PMC Article
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.
Capurso G, Gaujoux S, Pescatori LC, Panzuto F, Panis Y, Pilozzi E, Terris B, de Mestier L, Prat F, Rinzivillo M, Coriat R, Coulevard A, Delle Fave G, Ruszniewski P
Dig Liver Dis 2019 Dec;51(12):1725-1730. Epub 2019 Aug 9 doi: 10.1016/j.dld.2019.07.011. PMID: 31405587
The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure.
Okubo Y, Motohashi O, Nakayama N, Nishimura K, Kasajima R, Miyagi Y, Shiozawa M, Yoshioka E, Suzuki M, Washimi K, Kawachi K, Nito M, Kameda Y, Yokose T
Diagn Pathol 2016 Nov 8;11(1):128. doi: 10.1186/s13000-016-0580-5. PMID: 27821179Free PMC Article
Prevalence and prognostic significance of endocrine cells in colorectal adenocarcinomas.
Lapertosa G, Baracchini P, Delucchi F
Pathologica 1994 Apr;86(2):170-3. PMID: 7936761

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...