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Delayed Puberty

MedGen UID:
46203
Concept ID:
C0034012
Pathologic Function
Synonyms: Puberty, Delayed
SNOMED CT: Delayed puberty (400003000); Delay in sexual development AND/OR puberty (123526007); Delayed sexual development (123526007); Delayed puberty (123526007)
 

Definition

The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not. [from MeSH]

Term Hierarchy

Recent clinical studies

Etiology

Zhu J, Choa RE, Guo MH, Plummer L, Buck C, Palmert MR, Hirschhorn JN, Seminara SB, Chan YM
J Clin Endocrinol Metab 2015 Apr;100(4):E646-54. Epub 2015 Jan 30 doi: 10.1210/jc.2015-1080. [Epub ahead of print] PMID: 25636053Free PMC Article
Lawaetz JG, Hagen CP, Mieritz MG, Blomberg Jensen M, Petersen JH, Juul A
J Clin Endocrinol Metab 2015 Apr;100(4):1376-85. Epub 2015 Jan 16 doi: 10.1210/jc.2014-3631. [Epub ahead of print] PMID: 25594861
Hess O, Khayat M, Hwa V, Heath KE, Teitler A, Hritan Y, Allon-Shalev S, Tenenbaum-Rakover Y
Clin Endocrinol (Oxf) 2013 Dec;79(6):838-44. Epub 2013 Apr 13 doi: 10.1111/cen.12200. [Epub ahead of print] PMID: 23488611
Ali L, Adeel A
J Ayub Med Coll Abbottabad 2012 Apr-Jun;24(2):73-6. PMID: 24397058
Murray PG, Read A, Banerjee I, Whatmore AJ, Pritchard LE, Davies RA, Brennand J, White A, Ross RJ, Clayton PE
Eur J Endocrinol 2011 Apr;164(4):521-7. Epub 2011 Feb 4 doi: 10.1530/EJE-10-0656. [Epub ahead of print] PMID: 21296922

Diagnosis

Lawaetz JG, Hagen CP, Mieritz MG, Blomberg Jensen M, Petersen JH, Juul A
J Clin Endocrinol Metab 2015 Apr;100(4):1376-85. Epub 2015 Jan 16 doi: 10.1210/jc.2014-3631. [Epub ahead of print] PMID: 25594861
J Clin Endocrinol Metab 2013 Feb;98(2):31A-2A. doi: 10.1210/jcem.98.2.zeg31a. PMID: 23390269
Haller W, Zacharin M, Catto-Smith AG
J Pediatr 2013 May;162(5):1073.e1. Epub 2012 Dec 21 doi: 10.1016/j.jpeds.2012.11.033. [Epub ahead of print] PMID: 23260262
Maggi M, Buvat J
J Sex Med 2013 Jan;10(1):285-93. Epub 2012 Feb 29 doi: 10.1111/j.1743-6109.2012.02678.x. [Epub ahead of print] PMID: 22376050
Fenichel P
Endocr Dev 2012;22:138-59. Epub 2012 Jul 25 doi: 10.1159/000326686. [Epub ahead of print] PMID: 22846526

Therapy

Lawaetz JG, Hagen CP, Mieritz MG, Blomberg Jensen M, Petersen JH, Juul A
J Clin Endocrinol Metab 2015 Apr;100(4):1376-85. Epub 2015 Jan 16 doi: 10.1210/jc.2014-3631. [Epub ahead of print] PMID: 25594861
Quaynor SD, Stradtman EW Jr, Kim HG, Shen Y, Chorich LP, Schreihofer DA, Layman LC
N Engl J Med 2013 Jul 11;369(2):164-71. doi: 10.1056/NEJMoa1303611. PMID: 23841731Free PMC Article
Upreti V, Dhull P, Patnaik SK, Kumar KV
J Pediatr Endocrinol Metab 2012;25(11-12):1157-60. PMID: 23444474
Palmert MR, Dunkel L
N Engl J Med 2012 Feb 2;366(5):443-53. doi: 10.1056/NEJMcp1109290. PMID: 22296078
Mathew M, Cherian A
Singapore Med J 2012 Jan;53(1):e15-7. PMID: 22252192

Prognosis

Lawaetz JG, Hagen CP, Mieritz MG, Blomberg Jensen M, Petersen JH, Juul A
J Clin Endocrinol Metab 2015 Apr;100(4):1376-85. Epub 2015 Jan 16 doi: 10.1210/jc.2014-3631. [Epub ahead of print] PMID: 25594861
Ali L, Adeel A
J Ayub Med Coll Abbottabad 2012 Apr-Jun;24(2):73-6. PMID: 24397058
Fenichel P
Endocr Dev 2012;22:138-59. Epub 2012 Jul 25 doi: 10.1159/000326686. [Epub ahead of print] PMID: 22846526
Manjunatha RS, Varughese G, Phelan C, Clayton RN
N Z Med J 2010 Sep 10;123(1322):78-80. PMID: 20930896
Kaplowitz P
J Pediatr 1998 Dec;133(6):745-9. PMID: 9842037

Clinical prediction guides

Lawaetz JG, Hagen CP, Mieritz MG, Blomberg Jensen M, Petersen JH, Juul A
J Clin Endocrinol Metab 2015 Apr;100(4):1376-85. Epub 2015 Jan 16 doi: 10.1210/jc.2014-3631. [Epub ahead of print] PMID: 25594861
Rogol AD, Swerdloff RS, Reiter EO, Ross JL, ZumBrunnen TL, Pratt GA, Brennan JJ, Benesh J, Kan-Dobrosky N, Miller MG
J Adolesc Health 2014 Jan;54(1):20-5. Epub 2013 Sep 13 doi: 10.1016/j.jadohealth.2013.07.021. [Epub ahead of print] PMID: 24035132
Maggi M, Buvat J
J Sex Med 2013 Jan;10(1):285-93. Epub 2012 Feb 29 doi: 10.1111/j.1743-6109.2012.02678.x. [Epub ahead of print] PMID: 22376050
Kaplowitz P
J Pediatr 1998 Dec;133(6):745-9. PMID: 9842037
Giusti M, Valenti S, Giordano G
Recenti Prog Med 1992 Nov;83(11):634-8. PMID: 1287751

Recent systematic reviews

Gasparetto M, Guariso G
World J Gastroenterol 2014 Oct 7;20(37):13219-33. doi: 10.3748/wjg.v20.i37.13219. PMID: 25309059Free PMC Article
Kim YM, Kang M, Choi JH, Lee BH, Kim GH, Ohn JH, Kim SY, Park MS, Yoo HW
Metabolism 2014 Jan;63(1):42-9. Epub 2013 Oct 18 doi: 10.1016/j.metabol.2013.08.015. [Epub ahead of print] PMID: 24140098
Maggi M, Buvat J
J Sex Med 2013 Jan;10(1):285-93. Epub 2012 Feb 29 doi: 10.1111/j.1743-6109.2012.02678.x. [Epub ahead of print] PMID: 22376050
Kaur KK, Allahbadia G, Singh M
J Assist Reprod Genet 2012 Oct;29(10):999-1011. Epub 2012 Sep 27 doi: 10.1007/s10815-012-9856-1. [Epub ahead of print] PMID: 23015158Free PMC Article
Harrington J, Palmert MR
J Clin Endocrinol Metab 2012 Sep;97(9):3056-67. Epub 2012 Jun 20 doi: 10.1210/jc.2012-1598. [Epub ahead of print] PMID: 22723321

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