U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Coronary artery spasm 2, susceptibility to

MedGen UID:
461056
•Concept ID:
C3149706
•
Finding
Synonym: CORONARY ARTERY SPASM 2, SUSCEPTIBILITY TO
 
OMIM®: 168820

Professional guidelines

PubMed

The role of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes in alcohol-induced vasospastic angina.
Seki T, Okayama H, Isoyama S, Kagaya Y, Shirato K, Munakata K, Kanazawa M, Tamaki K, Hiramoto T, Okayama M, Kasahara S
Tohoku J Exp Med 1999 Apr;187(4):311-22. doi: 10.1620/tjem.187.311. PMID: 10503603

Recent clinical studies

Etiology

Familial risk of vasospastic angina: a nationwide family study in Sweden.
Ricci F, Banihashemi B, Pirouzifard M, Sundquist J, Sundquist K, Sutton R, Fedorowski A, Zoller B
Open Heart 2023 Dec 6;10(2) doi: 10.1136/openhrt-2023-002504. PMID: 38056914Free PMC Article
The effect of vasodilatory medications on radial artery spasm in patients undergoing transradial coronary artery procedures: a systematic review.
Curtis E, Fernandez R, Lee A
JBI Database System Rev Implement Rep 2017 Jul;15(7):1952-1967. doi: 10.11124/JBISRIR-2016-003039. PMID: 28708754
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction.
Mizuno Y, Hokimoto S, Harada E, Kinoshita K, Nakagawa K, Yoshimura M, Ogawa H, Yasue H
J Am Heart Assoc 2016 May 6;5(5) doi: 10.1161/JAHA.116.003247. PMID: 27153870Free PMC Article
Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.
Smith KJ, Chadburn AJ, Adomaviciene A, Minoretti P, Vignali L, Emanuele E, Tammaro P
Int J Cardiol 2013 Oct 9;168(4):3506-13. Epub 2013 Jun 3 doi: 10.1016/j.ijcard.2013.04.210. PMID: 23739550
A psychobehavioral factor, alexithymia, is related to coronary spasm.
Numata Y, Ogata Y, Oike Y, Matsumura T, Shimada K
Jpn Circ J 1998 Jun;62(6):409-13. doi: 10.1253/jcj.62.409. PMID: 9652315

Diagnosis

Familial risk of vasospastic angina: a nationwide family study in Sweden.
Ricci F, Banihashemi B, Pirouzifard M, Sundquist J, Sundquist K, Sutton R, Fedorowski A, Zoller B
Open Heart 2023 Dec 6;10(2) doi: 10.1136/openhrt-2023-002504. PMID: 38056914Free PMC Article
Acute ST Elevation Myocardial Infarction Due to Allergic Reaction, Kounis Syndrome.
Rajha E, Didi A, Dakik H, Mufarrij A
Am J Emerg Med 2020 Feb;38(2):409.e5-409.e7. Epub 2019 Nov 16 doi: 10.1016/j.ajem.2019.10.006. PMID: 31785976
Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.
Smith KJ, Chadburn AJ, Adomaviciene A, Minoretti P, Vignali L, Emanuele E, Tammaro P
Int J Cardiol 2013 Oct 9;168(4):3506-13. Epub 2013 Jun 3 doi: 10.1016/j.ijcard.2013.04.210. PMID: 23739550
Possible role of high susceptibility of high-density lipoprotein to lipid peroxidative modification and oxidized high-density lipoprotein in genesis of coronary artery spasm.
Ohmura H, Watanabe Y, Hatsumi C, Sato H, Daida H, Mokuno H, Yamaguchi H
Atherosclerosis 1999 Jan;142(1):179-84. doi: 10.1016/s0021-9150(98)00235-4. PMID: 9920519
Coronary and peripheral arterial responses to ergometrine in patients susceptible to coronary and oesophageal spasm.
Dalal JJ, Dart AM, Davies HA, Sheridan DJ, Ruttley MS, Henderson AH
Br Heart J 1981 Feb;45(2):181-5. doi: 10.1136/hrt.45.2.181. PMID: 7459176Free PMC Article

Therapy

The effect of vasodilatory medications on radial artery spasm in patients undergoing transradial coronary artery procedures: a systematic review.
Curtis E, Fernandez R, Lee A
JBI Database System Rev Implement Rep 2017 Jul;15(7):1952-1967. doi: 10.11124/JBISRIR-2016-003039. PMID: 28708754
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction.
Mizuno Y, Hokimoto S, Harada E, Kinoshita K, Nakagawa K, Yoshimura M, Ogawa H, Yasue H
J Am Heart Assoc 2016 May 6;5(5) doi: 10.1161/JAHA.116.003247. PMID: 27153870Free PMC Article
Potent vasodilatory effect of fasudil on radial artery graft in coronary artery bypass operations.
Watanabe G, Yamaguchi S, Takagi T, Tomita S, Tuan PM
Ann Thorac Surg 2014 Mar;97(3):845-50. Epub 2013 Nov 26 doi: 10.1016/j.athoracsur.2013.10.027. PMID: 24286636
Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K
J Hum Genet 2010 Jan;55(1):42-9. Epub 2009 Nov 13 doi: 10.1038/jhg.2009.120. PMID: 19911011
Supersensitivity of coronary arteries in variant angina to spasm induced by intracoronary acetylcholine.
Miwa K, Goto M, Lee JD, Matsuyama F, Shimizu H, Kato T, Hara A, Nakamura T
Am J Cardiol 1988 Jan 1;61(1):77-82. doi: 10.1016/0002-9149(88)91308-2. PMID: 3337020

Prognosis

Masked inherited primary arrhythmia syndromes in sudden cardiac death patients accompanied by coronary vasospasm.
Lee KH, Park HW, Eun JN, Cho JG, Yoon NS, Kim MR, Ku YH, Park H, Lee SH, Kim JH, Kim MC, Kim WJ, Kim HK, Cho JY, Park KH, Sim DS, Yoon HJ, Kim KH, Hong YJ, Kim JH, Ahn Y, Jeong MH, Park JC
Korean J Intern Med 2017 Sep;32(5):836-846. Epub 2017 Aug 11 doi: 10.3904/kjim.2015.283. PMID: 28797161Free PMC Article
The effect of vasodilatory medications on radial artery spasm in patients undergoing transradial coronary artery procedures: a systematic review.
Curtis E, Fernandez R, Lee A
JBI Database System Rev Implement Rep 2017 Jul;15(7):1952-1967. doi: 10.11124/JBISRIR-2016-003039. PMID: 28708754
The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm.
Chang K, Baek SH, Seung KB, Kim PJ, Ihm SH, Chae JS, Kim JH, Hong SJ, Choi KB
Coron Artery Dis 2003 Jun;14(4):293-9. doi: 10.1097/01.mca.0000073080.69657.71. PMID: 12826928
Low density lipoprotein particles are small in patients with coronary vasospasm.
Miwa K
Int J Cardiol 2003 Feb;87(2-3):193-201. doi: 10.1016/s0167-5273(02)00250-4. PMID: 12559540
A psychobehavioral factor, alexithymia, is related to coronary spasm.
Numata Y, Ogata Y, Oike Y, Matsumura T, Shimada K
Jpn Circ J 1998 Jun;62(6):409-13. doi: 10.1253/jcj.62.409. PMID: 9652315

Clinical prediction guides

Familial risk of vasospastic angina: a nationwide family study in Sweden.
Ricci F, Banihashemi B, Pirouzifard M, Sundquist J, Sundquist K, Sutton R, Fedorowski A, Zoller B
Open Heart 2023 Dec 6;10(2) doi: 10.1136/openhrt-2023-002504. PMID: 38056914Free PMC Article
High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris-like symptoms due to coronary spasm in WHHLMI rabbits.
Koike T, Tamura S, Yu Y, Kuniyoshi N, Shiomi M
Exp Anim 2016 Nov 1;65(4):419-426. Epub 2016 Jun 14 doi: 10.1538/expanim.16-0035. PMID: 27301847Free PMC Article
Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K
J Hum Genet 2010 Jan;55(1):42-9. Epub 2009 Nov 13 doi: 10.1038/jhg.2009.120. PMID: 19911011
Similarities between Brugada syndrome and ischemia-induced ST-segment elevation. Clinical correlation and synergy.
Chinushi M, Furushima H, Tanabe Y, Washizuka T, Aizawaz Y
J Electrocardiol 2005 Oct;38(4 Suppl):18-21. doi: 10.1016/j.jelectrocard.2005.06.004. PMID: 16226069
Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparations.
Ahmed SR, Johansson BL, Karlsson MG, Souza DS, Dashwood MR, Loesch A
Histol Histopathol 2004 Apr;19(2):421-33. doi: 10.14670/HH-19.421. PMID: 15024703

Recent systematic reviews

The effect of vasodilatory medications on radial artery spasm in patients undergoing transradial coronary artery procedures: a systematic review.
Curtis E, Fernandez R, Lee A
JBI Database System Rev Implement Rep 2017 Jul;15(7):1952-1967. doi: 10.11124/JBISRIR-2016-003039. PMID: 28708754

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...