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Peptic ulcer

MedGen UID:
45384
Concept ID:
C0030920
Disease or Syndrome
Synonyms: Gastroduodenal Ulcer; Gastroduodenal Ulcers; Peptic Ulcer; Peptic Ulcers; Ulcer, Gastroduodenal; Ulcer, Peptic; Ulcers, Gastroduodenal; Ulcers, Peptic
SNOMED CT: Peptic ulcer disease (13200003); Peptic ulceration (13200003); PUD - Peptic ulcer disease (13200003); PU - Peptic ulcer (13200003); Peptic ulcer (13200003); Gastroduodenal ulcer (13200003)
 

Definition

A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain. -Starts between meals or during the night. -Briefly stops if you eat or take antacids. -Lasts for minutes to hours. -Comes and goes for several days or weeks. Peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. The most common cause is infection with a bacterium called Helicobacter pylori. Another cause is the long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) such as aspirin and ibuprofen. Stress and spicy foods do not cause ulcers, but can make them worse. . To see if you have an H. pylori infection, your doctor will test your blood, breath, or stool. Your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. Peptic ulcers will get worse if not treated. Treatment may include medicines to reduce stomach acids or antibiotics to kill H. pylori. Antacids and milk can't heal peptic ulcers. Not smoking and avoiding alcohol can help. You may need surgery if your ulcers don't heal. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

Recent clinical studies

Etiology

Holland-Bill L, Christiansen CF, Gammelager H, Mortensen RN, Pedersen L, Sørensen HT
Aliment Pharmacol Ther 2015 Mar;41(6):564-72. Epub 2015 Jan 15 doi: 10.1111/apt.13073. [Epub ahead of print] PMID: 25588862
Ayadi S, Daghfous A, Saidani A, Haddad A, Magherbi H, Jouini M, Kacem M, Ben Safta Z
Tunis Med 2014 Oct;92(10):601-3. PMID: 25860673
Sałagacka A, Żebrowska M, Jeleń A, Mirowski M, Balcerczak E
Gut Liver 2014 Nov;8(6):632-6. Epub 2014 Nov 15 doi: 10.5009/gnl13224. PMID: 25368751Free PMC Article
Liao CH, Chang CS, Chang SN, Muo CH, Lane HY, Sung FC, Kao CH
J Psychosom Res 2014 Dec;77(6):541-6. Epub 2014 Aug 23 doi: 10.1016/j.jpsychores.2014.08.005. [Epub ahead of print] PMID: 25199406
Jung SH, Oh JH, Lee HY, Jeong JW, Go SE, You CR, Jeon EJ, Choi SW
World J Gastroenterol 2014 Feb 21;20(7):1846-51. doi: 10.3748/wjg.v20.i7.1846. PMID: 24587662Free PMC Article

Diagnosis

Holland-Bill L, Christiansen CF, Gammelager H, Mortensen RN, Pedersen L, Sørensen HT
Aliment Pharmacol Ther 2015 Mar;41(6):564-72. Epub 2015 Jan 15 doi: 10.1111/apt.13073. [Epub ahead of print] PMID: 25588862
Chan DK, Simonetto DA, Hauser SC
Mayo Clin Proc 2015 Jan;90(1):e1-5. Epub 2014 Nov 5 doi: 10.1016/j.mayocp.2014.05.022. [Epub ahead of print] PMID: 25572206
Ayadi S, Daghfous A, Saidani A, Haddad A, Magherbi H, Jouini M, Kacem M, Ben Safta Z
Tunis Med 2014 Oct;92(10):601-3. PMID: 25860673
Jung SH, Oh JH, Lee HY, Jeong JW, Go SE, You CR, Jeon EJ, Choi SW
World J Gastroenterol 2014 Feb 21;20(7):1846-51. doi: 10.3748/wjg.v20.i7.1846. PMID: 24587662Free PMC Article
Liang CC, Muo CH, Wang IK, Chang CT, Chou CY, Liu JH, Yen TH, Huang CC, Chung CJ
PLoS One 2014;9(2):e87952. Epub 2014 Feb 3 doi: 10.1371/journal.pone.0087952. PMID: 24498412Free PMC Article

Therapy

Ayadi S, Daghfous A, Saidani A, Haddad A, Magherbi H, Jouini M, Kacem M, Ben Safta Z
Tunis Med 2014 Oct;92(10):601-3. PMID: 25860673
Liao CH, Chang CS, Chang SN, Muo CH, Lane HY, Sung FC, Kao CH
J Psychosom Res 2014 Dec;77(6):541-6. Epub 2014 Aug 23 doi: 10.1016/j.jpsychores.2014.08.005. [Epub ahead of print] PMID: 25199406
Wu TC, Chuah SK, Chang KC, Wu CK, Kuo CH, Wu KL, Chiu YC, Hu TH, Tai WC
Biomed Res Int 2014;2014:906531. Epub 2014 Jul 1 doi: 10.1155/2014/906531. PMID: 25093189Free PMC Article
Güzel H, Kahramanca S, Şeker D, Özgehan G, Tunç G, Küçükpınar T, Kargıcı H
Turk J Gastroenterol 2014 Apr;25(2):152-5. doi: 10.5152/tjg.2014.5526. PMID: 25003674
Jung SH, Oh JH, Lee HY, Jeong JW, Go SE, You CR, Jeon EJ, Choi SW
World J Gastroenterol 2014 Feb 21;20(7):1846-51. doi: 10.3748/wjg.v20.i7.1846. PMID: 24587662Free PMC Article

Prognosis

Holland-Bill L, Christiansen CF, Gammelager H, Mortensen RN, Pedersen L, Sørensen HT
Aliment Pharmacol Ther 2015 Mar;41(6):564-72. Epub 2015 Jan 15 doi: 10.1111/apt.13073. [Epub ahead of print] PMID: 25588862
Ayadi S, Daghfous A, Saidani A, Haddad A, Magherbi H, Jouini M, Kacem M, Ben Safta Z
Tunis Med 2014 Oct;92(10):601-3. PMID: 25860673
Liao CH, Chang CS, Chang SN, Muo CH, Lane HY, Sung FC, Kao CH
J Psychosom Res 2014 Dec;77(6):541-6. Epub 2014 Aug 23 doi: 10.1016/j.jpsychores.2014.08.005. [Epub ahead of print] PMID: 25199406
Güzel H, Kahramanca S, Şeker D, Özgehan G, Tunç G, Küçükpınar T, Kargıcı H
Turk J Gastroenterol 2014 Apr;25(2):152-5. doi: 10.5152/tjg.2014.5526. PMID: 25003674
Jung SH, Oh JH, Lee HY, Jeong JW, Go SE, You CR, Jeon EJ, Choi SW
World J Gastroenterol 2014 Feb 21;20(7):1846-51. doi: 10.3748/wjg.v20.i7.1846. PMID: 24587662Free PMC Article

Clinical prediction guides

Ayadi S, Daghfous A, Saidani A, Haddad A, Magherbi H, Jouini M, Kacem M, Ben Safta Z
Tunis Med 2014 Oct;92(10):601-3. PMID: 25860673
Wang PY, Chen HP, Chen A, Tsay FW, Lai KH, Kao SS, Chen WC, Kuo CH, Peng NJ, Tseng HH, Hsu PI
Biomed Res Int 2014;2014:616018. Epub 2014 Aug 27 doi: 10.1155/2014/616018. PMID: 25243161Free PMC Article
Wu TC, Chuah SK, Chang KC, Wu CK, Kuo CH, Wu KL, Chiu YC, Hu TH, Tai WC
Biomed Res Int 2014;2014:906531. Epub 2014 Jul 1 doi: 10.1155/2014/906531. PMID: 25093189Free PMC Article
Akdogan RA, Ozgur O, Gucuyeter S, Kaklikkaya N, Cobanoglu U, Aydin F
Bratisl Lek Listy 2014;115(4):221-8. PMID: 24797597
Jung SH, Oh JH, Lee HY, Jeong JW, Go SE, You CR, Jeon EJ, Choi SW
World J Gastroenterol 2014 Feb 21;20(7):1846-51. doi: 10.3748/wjg.v20.i7.1846. PMID: 24587662Free PMC Article

Recent systematic reviews

Wu DD, Zhang JX, Li J, Dong WG
Asian Pac J Cancer Prev 2014;15(7):3021-7. PMID: 24815441
Søreide K, Thorsen K, Søreide JA
Br J Surg 2014 Jan;101(1):e51-64. Epub 2013 Nov 29 doi: 10.1002/bjs.9368. [Epub ahead of print] PMID: 24338777
Liu J, He C, Chen M, Wang Z, Xing C, Yuan Y
BMC Infect Dis 2013 Nov 20;13:555. doi: 10.1186/1471-2334-13-555. [Epub ahead of print] PMID: 24256489Free PMC Article
Al Dhahab H, McNabb-Baltar J, Al-Taweel T, Barkun A
Saudi J Gastroenterol 2013 Sep-Oct;19(5):195-204. doi: 10.4103/1319-3767.118116. PMID: 24045592Free PMC Article
Wong CS, Chia CF, Lee HC, Wei PL, Ma HP, Tsai SH, Wu CH, Tam KW
J Surg Res 2013 Jun 15;182(2):219-26. Epub 2012 Nov 9 doi: 10.1016/j.jss.2012.10.046. [Epub ahead of print] PMID: 23158404

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