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Cystocele

MedGen UID:
451932
Concept ID:
CN117537
Finding
 
HPO: HP:0100645

Definition

When the tough fibrous wall between a woman's bladder and her vagina (the pubocervical fascia) is torn, allowing the bladder to herniate into the vagina. [from HPO]

Conditions with this feature

Ehlers-Danlos syndrome, type 3
MedGen UID:
75670
Concept ID:
C0268337
Disease or Syndrome
Ehlers-Danlos syndrome (EDS), hypermobility type is generally considered the least severe type of EDS, although significant complications, primarily musculoskeletal, can and do occur. The skin is often soft or velvety and may be mildly hyperextensible. Subluxations and dislocations are common; they may occur spontaneously or with minimal trauma and can be acutely painful. Degenerative joint disease is common. Chronic pain, distinct from that associated with acute dislocations, is a serious complication of the condition and can be both physically and psychologically disabling. Easy bruising is common. Functional bowel disorders are likely underrecognized. Autonomic dysfunction, such as orthostatic intolerance, may also be seen. Aortic root dilation is typically of a mild degree with no increased risk of dissection in the absence of significant dilation. Psychological dysfunction, psychosocial impairment, and emotional problems are common.
Ehlers-Danlos syndrome, type 4
MedGen UID:
82790
Concept ID:
C0268338
Disease or Syndrome
Ehlers-Danlos syndrome type IV (EDS type IV) is characterized by thin, translucent skin; easy bruising; characteristic facial appearance (in some individuals); and arterial, intestinal, and/or uterine fragility. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in the majority of adults identified to have EDS type IV. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. Neonates may present with clubfoot and/or congenital dislocation of the hips. In childhood, inguinal hernia, pneumothorax, and recurrent joint subluxation or dislocation can occur. Pregnancy for women with EDS type IV has as much as a 12% risk for death from peripartum arterial rupture or uterine rupture. One-fourth of individuals with EDS type IV who have undergone laboratory testing to confirm their diagnosis have experienced a significant medical problem by age 20 years and more than 80% by age 40 years. The median age of death in this reviewed population was 48 years.

Recent clinical studies

Etiology

Wong V, Shek KL, Goh J, Krause H, Martin A, Dietz HP
Eur J Obstet Gynecol Reprod Biol 2014 Jan;172:131-5. Epub 2013 Nov 9 doi: 10.1016/j.ejogrb.2013.11.001. [Epub ahead of print] PMID: 24314800
Chang TC, Hsiao SM, Chen CH, Wu WY, Lin HH
Eur J Obstet Gynecol Reprod Biol 2014 Jan;172:127-30. Epub 2013 Oct 12 doi: 10.1016/j.ejogrb.2013.10.008. [Epub ahead of print] PMID: 24183347
Wong V, Shek K, Rane A, Goh J, Krause H, Dietz HP
Ultrasound Obstet Gynecol 2013 Aug;42(2):230-4. doi: 10.1002/uog.12433. PMID: 23404827
Elliott CS, Yeh J, Comiter CV, Chen B, Sokol ER
J Urol 2013 Jan;189(1):200-3. Epub 2012 Nov 19 doi: 10.1016/j.juro.2012.08.177. [Epub ahead of print] PMID: 23174246
Park HK, Paick SH, Lho YS, Choo GY, Kim HG, Choi J
Int Urogynecol J 2013 Jul;24(7):1123-6. Epub 2012 Nov 3 doi: 10.1007/s00192-012-1961-2. [Epub ahead of print] PMID: 23124692

Diagnosis

Wong V, Shek KL, Goh J, Krause H, Martin A, Dietz HP
Eur J Obstet Gynecol Reprod Biol 2014 Jan;172:131-5. Epub 2013 Nov 9 doi: 10.1016/j.ejogrb.2013.11.001. [Epub ahead of print] PMID: 24314800
Chang TC, Hsiao SM, Chen CH, Wu WY, Lin HH
Eur J Obstet Gynecol Reprod Biol 2014 Jan;172:127-30. Epub 2013 Oct 12 doi: 10.1016/j.ejogrb.2013.10.008. [Epub ahead of print] PMID: 24183347
Wong V, Shek K, Rane A, Goh J, Krause H, Dietz HP
Ultrasound Obstet Gynecol 2013 Aug;42(2):230-4. doi: 10.1002/uog.12433. PMID: 23404827
Elliott CS, Yeh J, Comiter CV, Chen B, Sokol ER
J Urol 2013 Jan;189(1):200-3. Epub 2012 Nov 19 doi: 10.1016/j.juro.2012.08.177. [Epub ahead of print] PMID: 23174246
Chantarasorn V, Dietz HP
Ultrasound Obstet Gynecol 2012 Jun;39(6):710-4. doi: 10.1002/uog.10156. PMID: 22125257

Therapy

Turgal M, Sivaslioglu A, Yildiz A, Dolen I
Eur J Obstet Gynecol Reprod Biol 2013 Oct;170(2):555-8. Epub 2013 Aug 2 doi: 10.1016/j.ejogrb.2013.07.014. [Epub ahead of print] PMID: 23916584
Mousty E, Huberlant S, Pouget O, Mares P, de Tayrac R, Letouzey V
Prog Urol 2013 Jun;23(8):530-7. Epub 2013 May 8 doi: 10.1016/j.purol.2013.03.018. [Epub ahead of print] PMID: 23725584
Nüssler EK, Greisen S, Kesmodel US, Löfgren M, Bek KM, Glavind-Kristensen M
Int Urogynecol J 2013 Nov;24(11):1925-31. Epub 2013 May 3 doi: 10.1007/s00192-013-2110-2. [Epub ahead of print] PMID: 23640006
Park HK, Paick SH, Lho YS, Choo GY, Kim HG, Choi J
Int Urogynecol J 2013 Jul;24(7):1123-6. Epub 2012 Nov 3 doi: 10.1007/s00192-012-1961-2. [Epub ahead of print] PMID: 23124692
Lee DS, Park DC, Choe HS, Choi JB, Lee SJ
Urol Int 2012;88(4):415-22. Epub 2012 May 23 doi: 10.1159/000336868. [Epub ahead of print] PMID: 22627107

Prognosis

Mousty E, Huberlant S, Pouget O, Mares P, de Tayrac R, Letouzey V
Prog Urol 2013 Jun;23(8):530-7. Epub 2013 May 8 doi: 10.1016/j.purol.2013.03.018. [Epub ahead of print] PMID: 23725584
Paganotto MC, Amadori L, Di Donato N, Mauloni M, Busacchi P
Minerva Ginecol 2013 Jun;65(3):319-26. PMID: 23689175
Wong V, Shek K, Rane A, Goh J, Krause H, Dietz HP
Ultrasound Obstet Gynecol 2013 Aug;42(2):230-4. doi: 10.1002/uog.12433. PMID: 23404827
Elliott CS, Yeh J, Comiter CV, Chen B, Sokol ER
J Urol 2013 Jan;189(1):200-3. Epub 2012 Nov 19 doi: 10.1016/j.juro.2012.08.177. [Epub ahead of print] PMID: 23174246
Mourtialon P, Letouzey V, Eglin G, de Tayrac R; French Ugytex Study Group
Int Urogynecol J 2012 Jun;23(6):699-706. Epub 2012 Jan 17 doi: 10.1007/s00192-011-1650-6. [Epub ahead of print] PMID: 22249280

Clinical prediction guides

Wong V, Shek K, Rane A, Goh J, Krause H, Dietz HP
Ultrasound Obstet Gynecol 2013 Aug;42(2):230-4. doi: 10.1002/uog.12433. PMID: 23404827
Elliott CS, Yeh J, Comiter CV, Chen B, Sokol ER
J Urol 2013 Jan;189(1):200-3. Epub 2012 Nov 19 doi: 10.1016/j.juro.2012.08.177. [Epub ahead of print] PMID: 23174246
Park HK, Paick SH, Lho YS, Choo GY, Kim HG, Choi J
Int Urogynecol J 2013 Jul;24(7):1123-6. Epub 2012 Nov 3 doi: 10.1007/s00192-012-1961-2. [Epub ahead of print] PMID: 23124692
Lee DS, Park DC, Choe HS, Choi JB, Lee SJ
Urol Int 2012;88(4):415-22. Epub 2012 May 23 doi: 10.1159/000336868. [Epub ahead of print] PMID: 22627107
Chantarasorn V, Dietz HP
Ultrasound Obstet Gynecol 2012 Jun;39(6):710-4. doi: 10.1002/uog.10156. PMID: 22125257

Recent systematic reviews

Maher C
Int Urogynecol J 2013 Nov;24(11):1791-802. doi: 10.1007/s00192-013-2170-3. PMID: 24142055
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;4:CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316
Yurteri-Kaplan LA, Gutman RE
Plast Reconstr Surg 2012 Nov;130(5 Suppl 2):242S-53S. doi: 10.1097/PRS.0b013e31826154e4. PMID: 23096979
Marchese K
Urol Nurs 2009 Jul-Aug;29(4):216-23. PMID: 19718936
ACOG Committee on Practice Bulletins--Gynecology
Obstet Gynecol 2007 Sep;110(3):717-29. doi: 10.1097/01.AOG.0000263925.97887.72. PMID: 17766624

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