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Down-regulation

MedGen UID:
4386
•Concept ID:
C0013081
•
Molecular Function
Synonyms: Down Regulation; Down-Regulation; Down-Regulation (Physiology); Downregulation
SNOMED CT: Down-regulation, function (49764008); Down-regulation (49764008)

Definition

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

Professional guidelines

PubMed

Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights.
Galicia-Garcia U, Jebari S, Larrea-Sebal A, Uribe KB, Siddiqi H, Ostolaza H, Benito-Vicente A, Martín C
Int J Mol Sci 2020 Jul 2;21(13) doi: 10.3390/ijms21134725. PMID: 32630698Free PMC Article
Treatment of urticaria: a clinical and mechanistic approach.
Kaplan AP
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):387-392. doi: 10.1097/ACI.0000000000000538. PMID: 31246664
MicroRNAs in the Diagnosis and Treatment of Cancer.
Mansoori B, Mohammadi A, Shirjang S, Baradaran B
Immunol Invest 2017 Nov;46(8):880-897. doi: 10.1080/08820139.2017.1377407. PMID: 29058545

Recent clinical studies

Etiology

Protein S: a Central Regulator of Blood Coagulation.
Alshaikh NA
Clin Lab 2022 Aug 1;68(8) doi: 10.7754/Clin.Lab.2021.211010. PMID: 35975485
Long non-coding RNAs: Diverse roles in various disorders.
Azizi Z, Mirtavoos-Mahyari H, Karimi R, Noroozi Z, Motevaseli E
Hum Antibodies 2019;27(4):221-225. doi: 10.3233/HAB-190374. PMID: 30909207
Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?
Biglino G, Caputo M, Rajakaruna C, Angelini G, van Rooij E, Emanueli C
Pharmacol Ther 2017 Feb;170:192-204. Epub 2016 Nov 27 doi: 10.1016/j.pharmthera.2016.11.004. PMID: 27902930
Fluoroquinolone-associated tendinopathy.
Tsai WC, Yang YM
Chang Gung Med J 2011 Sep-Oct;34(5):461-7. PMID: 22035890
MAGED1: molecular insights and clinical implications.
Wang X, Gao X, Xu Y
Ann Med 2011 Aug;43(5):347-55. Epub 2011 May 25 doi: 10.3109/07853890.2011.573806. PMID: 21612333

Diagnosis

Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer.
Xi S, Ming DJ, Zhang JH, Guo MM, Wang SY, Cai Y, Liu MY, Wang DQ, Zhang YJ, Li Y, Yuan S
Cell Death Dis 2023 Jun 13;14(6):359. doi: 10.1038/s41419-023-05880-3. PMID: 37311754Free PMC Article
Recent trends in cancer therapy: A review on the current state of gene delivery.
Yahya EB, Alqadhi AM
Life Sci 2021 Mar 15;269:119087. Epub 2021 Jan 19 doi: 10.1016/j.lfs.2021.119087. PMID: 33476633
Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions.
Scheffzek K, Shivalingaiah G
Cold Spring Harb Perspect Med 2019 Mar 1;9(3) doi: 10.1101/cshperspect.a031500. PMID: 30104198Free PMC Article
The role of miR-148a in gastric cancer.
Xia J, Guo X, Yan J, Deng K
J Cancer Res Clin Oncol 2014 Sep;140(9):1451-6. doi: 10.1007/s00432-014-1649-8. PMID: 24659367
Fluoroquinolone-associated tendinopathy.
Tsai WC, Yang YM
Chang Gung Med J 2011 Sep-Oct;34(5):461-7. PMID: 22035890

Therapy

The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.
Schoeneck M, Iggman D
Nutr Metab Cardiovasc Dis 2021 May 6;31(5):1325-1338. Epub 2021 Jan 16 doi: 10.1016/j.numecd.2020.12.032. PMID: 33762150
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.
Guo J, Ren R, Sun K, Yao X, Lin J, Wang G, Guo Z, Xu T, Guo F
Cell Death Dis 2020 Oct 13;11(10):847. doi: 10.1038/s41419-020-03046-z. PMID: 33051453Free PMC Article
Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts.
Chen K, Liu Y, He J, Pavlos N, Wang C, Kenny J, Yuan J, Zhang Q, Xu J, He W
Int J Biol Sci 2020;16(11):1888-1900. Epub 2020 Apr 6 doi: 10.7150/ijbs.40917. PMID: 32398957Free PMC Article
Trace of survivin in cancer.
Shojaei F, Yazdani-Nafchi F, Banitalebi-Dehkordi M, Chehelgerdi M, Khorramian-Ghahfarokhi M
Eur J Cancer Prev 2019 Jul;28(4):365-372. doi: 10.1097/CEJ.0000000000000453. PMID: 29847456
Efficacy and Safety of White Willow Bark (Salix alba) Extracts.
Shara M, Stohs SJ
Phytother Res 2015 Aug;29(8):1112-6. Epub 2015 May 22 doi: 10.1002/ptr.5377. PMID: 25997859

Prognosis

Molecular Markers for Long-term Survival in Stage IIIA (N2) NSCLC Patients.
Nastase A, Dima SO, Lupo A, Laszlo V, Tagett R, Draghici S, Georgescu ME, Nechifor A, Berbece S, Popescu I, Alifano M, Klepetko W, Grigoroiu M
Cancer Genomics Proteomics 2022 Jan-Feb;19(1):94-104. doi: 10.21873/cgp.20306. PMID: 34949662Free PMC Article
Tumor Suppressor Effect of RBMS3 in Breast Cancer.
Wang C, Wu Y, Liu Y, Pan F, Zeng H, Li X, Yu L
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211004921. doi: 10.1177/15330338211004921. PMID: 33910421Free PMC Article
Down-regulation of microRNA152 is associated with the diagnosis and prognosis of patients with osteosarcoma.
Wang NG, Wang DC, Tan BY, Wang F, Yuan ZN
Int J Clin Exp Pathol 2015;8(8):9314-9. Epub 2015 Aug 1 PMID: 26464682Free PMC Article
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.
Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R
Chest 2007 Apr;131(4):954-63. doi: 10.1378/chest.06-2100. PMID: 17426195
The management of retinopathy of prematurity.
Reynolds JD
Paediatr Drugs 2001;3(4):263-72. doi: 10.2165/00128072-200103040-00003. PMID: 11354698

Clinical prediction guides

Insights Into the Metabolic Aspects of Aortic Stenosis With the Use of Magnetic Resonance Imaging.
Monga S, Valkovič L, Tyler D, Lygate CA, Rider O, Myerson SG, Neubauer S, Mahmod M
JACC Cardiovasc Imaging 2022 Dec;15(12):2112-2126. Epub 2022 Jun 15 doi: 10.1016/j.jcmg.2022.04.025. PMID: 36481080Free PMC Article
Severe hyponatremia after donor nephrectomy.
Ibrahim IA, Hassan EA, Ali TZ, Brockmann JG, Aleid HA
Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):515-520. doi: 10.4103/1319-2442.284028. PMID: 32394926
Combining cholesterol-lowering strategies with imaging data: a visible benefit?
Koenig W, Giovas P, Nicholls SJ
Eur J Prev Cardiol 2019 Mar;26(4):365-379. Epub 2018 Aug 30 doi: 10.1177/2047487318798059. PMID: 30160512
Prognostic value of Muc5AC in gastric cancer: A meta-analysis.
Zhang CT, He KC, Pan F, Li Y, Wu J
World J Gastroenterol 2015 Sep 28;21(36):10453-60. doi: 10.3748/wjg.v21.i36.10453. PMID: 26420972Free PMC Article
The basic biology of HER2.
Rubin I, Yarden Y
Ann Oncol 2001;12 Suppl 1:S3-8. doi: 10.1093/annonc/12.suppl_1.s3. PMID: 11521719

Recent systematic reviews

The molecular basis of immuno-radiotherapy.
Koukourakis IM, Tiniakos D, Kouloulias V, Zygogianni A
Int J Radiat Biol 2023;99(5):715-736. Epub 2022 Nov 16 doi: 10.1080/09553002.2023.2144960. PMID: 36383201
The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.
Schoeneck M, Iggman D
Nutr Metab Cardiovasc Dis 2021 May 6;31(5):1325-1338. Epub 2021 Jan 16 doi: 10.1016/j.numecd.2020.12.032. PMID: 33762150
Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis.
Nirgianakis K, Kalaitzopoulos DR, Schwartz ASK, Spaanderman M, Kramer BW, Mueller MD, Mueller M
Reprod Biomed Online 2021 Jan;42(1):185-206. Epub 2020 Oct 4 doi: 10.1016/j.rbmo.2020.09.023. PMID: 33191131
Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials.
Zhang X, Xing L, Jia X, Pang X, Xiang Q, Zhao X, Ma L, Liu Z, Hu K, Wang Z, Cui Y
Cardiovasc Ther 2020;2020:3987065. Epub 2020 Apr 23 doi: 10.1155/2020/3987065. PMID: 32411300Free PMC Article
Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.
Peyrin-Biroulet L, Williet N, Cacoub P
Am J Clin Nutr 2015 Dec;102(6):1585-94. Epub 2015 Nov 11 doi: 10.3945/ajcn.114.103366. PMID: 26561626

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