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Autonomic erectile dysfunction

MedGen UID:
358232
Concept ID:
C1868524
Finding
Synonyms: Impotence due to autonomic dysfunction
 
HPO: HP:0008652

Term Hierarchy

Conditions with this feature

Leukodystrophy, adult-onset, autosomal dominant
MedGen UID:
356995
Concept ID:
C1868512
Disease or Syndrome
Autosomal dominant adult-onset demyelinating leukodystrophy is a slowly progressive and fatal disorder that presents in the fourth or fifth decade of life and is characterized clinically by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. ADLD differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis (summary by Padiath et al., 2006). Characteristic MRI findings include T2-weighted hyperintense changes in the upper corticospinal tract and cerebellar peduncles, with later development of confluent white matter changes in the frontoparietal area with relative sparing of the periventricular white matter (summary by Schuster et al., 2011).

Recent clinical studies

Etiology

Tannus M, Costa DT, Castro NM, Oliveira P, Carvalho N, Andrade R, Santos S, Carvalho EM
Urology 2013 Jun;81(6):1261-4. doi: 10.1016/j.urology.2013.02.014. PMID: 23726450
Postuma RB, Gagnon JF, Pelletier A, Montplaisir J
Mov Disord 2013 May;28(5):597-604. Epub 2013 Mar 28 doi: 10.1002/mds.25445. [Epub ahead of print] PMID: 23554107
Andersson KE
Pharmacol Rev 2011 Dec;63(4):811-59. Epub 2011 Aug 31 doi: 10.1124/pr.111.004515. [Epub ahead of print] PMID: 21880989
Pereira de Souza Neto E, Fernández EA, Abry P, Cuzin B, Loiseau P, Baude C, Frutoso J, Gharib C, Martin X
Urol Int 2011;86(3):290-7. Epub 2010 Dec 3 doi: 10.1159/000322069. [Epub ahead of print] PMID: 21124015
Dogru MT, Basar MM
Int Urol Nephrol 2010 Sep;42(3):589-96. Epub 2009 Oct 29 doi: 10.1007/s11255-009-9658-2. [Epub ahead of print] PMID: 19866371

Diagnosis

Spritzer SD, Zarkou S, Ireland SP, Carter JL, Goodman BP
Clin Auton Res 2013 Dec;23(6):333-8. Epub 2013 Aug 8 doi: 10.1007/s10286-013-0205-y. [Epub ahead of print] PMID: 23925719
Postuma RB, Gagnon JF, Pelletier A, Montplaisir J
Mov Disord 2013 May;28(5):597-604. Epub 2013 Mar 28 doi: 10.1002/mds.25445. [Epub ahead of print] PMID: 23554107
Oguanobi NI, Onwubere BJ, Anisiuba BC, Ike SO, Ejim EC, Ibegbulam OG
Acta Cardiol 2012 Apr;67(2):169-75. PMID: 22641974
Pereira de Souza Neto E, Fernández EA, Abry P, Cuzin B, Loiseau P, Baude C, Frutoso J, Gharib C, Martin X
Urol Int 2011;86(3):290-7. Epub 2010 Dec 3 doi: 10.1159/000322069. [Epub ahead of print] PMID: 21124015
Dogru T, Kocak OM, Erberk-Ozen N, Basar M
Asian J Androl 2008 Jul;10(4):643-50. doi: 10.1111/j.1745-7262.2008.00383.x. PMID: 18478163

Therapy

Lythgoe C, McVary KT
Curr Urol Rep 2013 Dec;14(6):585-94. doi: 10.1007/s11934-013-0373-2. PMID: 24136683
Perez-Lloret S, Rey MV, Pavy-Le Traon A, Rascol O
Expert Opin Emerg Drugs 2013 Mar;18(1):39-53. Epub 2013 Feb 1 doi: 10.1517/14728214.2013.766168. [Epub ahead of print] PMID: 23373820
Harv Heart Lett 2012 Sep;23(1):5. PMID: 23101129
Andersson KE
Pharmacol Rev 2011 Dec;63(4):811-59. Epub 2011 Aug 31 doi: 10.1124/pr.111.004515. [Epub ahead of print] PMID: 21880989
Siepmann T, Roofeh J, Kiefer FW, Edelson DG
Nutrition 2011 Jul-Aug;27(7-8):859-62. Epub 2011 Feb 25 doi: 10.1016/j.nut.2010.10.018. [Epub ahead of print] PMID: 21353476

Prognosis

Kneist W, Kauff DW, Rubenwolf P, Thomas C, Hampel C, Lang H
Dig Surg 2013;30(4-6):459-65. Epub 2014 Jan 29 doi: 10.1159/000357349. [Epub ahead of print] PMID: 24481247
Hida K, Hasegawa S, Kataoka Y, Nagayama S, Yoshimura K, Nomura A, Kawada K, Kawamura J, Kinjo Y, Sakai Y
Colorectal Dis 2013 Feb;15(2):244-51. doi: 10.1111/j.1463-1318.2012.03170.x. PMID: 22776077
Kim JY, Kim NK, Lee KY, Hur H, Min BS, Kim JH
Ann Surg Oncol 2012 Aug;19(8):2485-93. Epub 2012 Mar 21 doi: 10.1245/s10434-012-2262-1. [Epub ahead of print] PMID: 22434245
Chitaley K, Kupelian V, Subak L, Wessells H
J Urol 2009 Dec;182(6 Suppl):S45-50. doi: 10.1016/j.juro.2009.07.089. PMID: 19846136Free PMC Article
Dogru T, Kocak OM, Erberk-Ozen N, Basar M
Asian J Androl 2008 Jul;10(4):643-50. doi: 10.1111/j.1745-7262.2008.00383.x. PMID: 18478163

Clinical prediction guides

Tannus M, Costa DT, Castro NM, Oliveira P, Carvalho N, Andrade R, Santos S, Carvalho EM
Urology 2013 Jun;81(6):1261-4. doi: 10.1016/j.urology.2013.02.014. PMID: 23726450
Postuma RB, Gagnon JF, Pelletier A, Montplaisir J
Mov Disord 2013 May;28(5):597-604. Epub 2013 Mar 28 doi: 10.1002/mds.25445. [Epub ahead of print] PMID: 23554107
Dogru MT, Basar MM, Haciislamoglu A
Ann Noninvasive Electrocardiol 2010 Jul;15(3):223-9. doi: 10.1111/j.1542-474X.2010.00368.x. PMID: 20645964
Dogru MT, Basar MM
Int Urol Nephrol 2010 Sep;42(3):589-96. Epub 2009 Oct 29 doi: 10.1007/s11255-009-9658-2. [Epub ahead of print] PMID: 19866371
Dogru T, Kocak OM, Erberk-Ozen N, Basar M
Asian J Androl 2008 Jul;10(4):643-50. doi: 10.1111/j.1745-7262.2008.00383.x. PMID: 18478163

Recent systematic reviews

Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, Hametner EM, Poewe W, Rascol O, Goetz CG, Sampaio C
Mov Disord 2011 Oct;26 Suppl 3:S42-80. doi: 10.1002/mds.23884. PMID: 22021174Free PMC Article
Wood LD, Neumiller JJ, Setter SM, Dobbins EK
Am J Geriatr Pharmacother 2010 Aug;8(4):294-315. doi: 10.1016/j.amjopharm.2010.08.002. PMID: 20869620
Kirby MG, Wagg A, Cardozo L, Chapple C, Castro-Diaz D, de Ridder D, Espuna-Pons M, Haab F, Kelleher C, Kölbl H, Milsom I, Van Kerrebroeck P, Vierhout M, Salvatore S, Tubaro A
Neurourol Urodyn 2010 Nov;29(8):1360-4. doi: 10.1002/nau.20892. PMID: 20589717
Jin LM
J Sex Med 2009 Mar;6 Suppl 3:302-10. doi: 10.1111/j.1743-6109.2008.01188.x. PMID: 19267853
Broderick GA
Int J Impot Res 1998 May;10 Suppl 2:S64-73; discussion S77-9. PMID: 9647964

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