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Premature coronary artery disease

MedGen UID:
356830
Concept ID:
C1867743
Finding
Synonyms: Coronary artery disease, premature
 
HPO: HP:0005181

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Premature coronary artery disease

Conditions with this feature

Hutchinson-Gilford syndrome
MedGen UID:
46123
Concept ID:
C0033300
Disease or Syndrome
Hutchinson-Gilford progeria syndrome encompasses a spectrum of clinical features that typically develop in childhood and resemble some features of accelerated aging. Although signs and symptoms vary in age of onset and severity, they are remarkably consistent overall. Children with Hutchinson-Gilford progeria syndrome (HGPS) usually appear normal at birth. Profound failure to thrive occurs during the first year. Characteristic facies, with receding mandible, narrow nasal bridge and pointed nasal tip develop. During the first to third year the following usually become apparent: partial alopecia progressing to total alopecia, loss of subcutaneous fat, progressive joint contractures, bone changes, nail dystrophy, and abnormal tightness and/or small soft outpouchings of the skin over the abdomen and upper thighs, and delayed primary tooth eruption. Later findings include low-frequency conductive hearing loss, dental crowding, and partial lack of secondary tooth eruption. Additional findings present in some but not all affected individuals include photophobia, excessive ocular tearing, exposure keratitis, and Raynaud phenomenon. Motor and mental development is normal. Death occurs as a result of complications of severe atherosclerosis, either cardiac disease (myocardial infarction) or cerebrovascular disease (stroke), generally between ages six and 20 years. Average life span is approximately 14.6 years.
Aortic aneurysm, familial thoracic 6
MedGen UID:
435866
Concept ID:
C2673186
Disease or Syndrome
The major cardiovascular manifestations of thoracic aortic aneurysms and aortic dissections (TAAD) include: (1) dilatation of the ascending thoracic aorta at the level of the sinuses of Valsalva or ascending aorta or both; and (2) dissections of the thoracic aorta involving either the ascending (Stanford type A dissections) or descending aorta (Stanford type B). Rarely an aneurysm involving the descending thoracic aorta is observed. Vascular manifestations can be the only findings. In the absence of surgical repair of the ascending aorta, affected individuals typically have progressive enlargement of the ascending aorta leading to an acute aortic dissection. The age of onset and presentation of the aortic disease are highly variable, as are the other vascular diseases and features associated with the aortic disease.
Morbid obesity and spermatogenic failure
MedGen UID:
816654
Concept ID:
C3810324
Disease or Syndrome

Recent clinical studies

Etiology

Abdi-Ali A, Shaheen A, Southern D, Zhang M, Knudtson M, White J, Graham M, James MT, Wilton SB
Am J Cardiol 2016 Feb 1;117(3):353-8. Epub 2015 Nov 18 doi: 10.1016/j.amjcard.2015.11.008. [Epub ahead of print] PMID: 26723106
Mohammad AM, Jehangeer HI, Shaikhow SK
BMC Cardiovasc Disord 2015 Nov 18;15:155. doi: 10.1186/s12872-015-0145-7. [Epub ahead of print] PMID: 26582255Free PMC Article
Angeles-Martínez J, Posadas-Sánchez R, Álvarez-León E, Villarreal-Molina T, Cardoso-Saldaña G, Fragoso JM, Juárez-Rojas JG, Medina-Urrutia A, Posadas-Romero C, Vargas-Alarcón G
Immunol Lett 2015 Oct;167(2):125-30. Epub 2015 Aug 12 doi: 10.1016/j.imlet.2015.08.003. [Epub ahead of print] PMID: 26277553
Hou X, Chen X, Shi J
Gene 2015 Jul 1;565(1):39-44. Epub 2015 Mar 31 doi: 10.1016/j.gene.2015.03.062. [Epub ahead of print] PMID: 25839940
Xie F, Chen Z, Ding Z, Ma G
Mol Biol Rep 2013 May;40(5):3649-54. Epub 2012 Dec 25 doi: 10.1007/s11033-012-2440-z. [Epub ahead of print] PMID: 23266671

Diagnosis

Mohammad AM, Jehangeer HI, Shaikhow SK
BMC Cardiovasc Disord 2015 Nov 18;15:155. doi: 10.1186/s12872-015-0145-7. [Epub ahead of print] PMID: 26582255Free PMC Article
Angeles-Martínez J, Posadas-Sánchez R, Álvarez-León E, Villarreal-Molina T, Cardoso-Saldaña G, Fragoso JM, Juárez-Rojas JG, Medina-Urrutia A, Posadas-Romero C, Vargas-Alarcón G
Immunol Lett 2015 Oct;167(2):125-30. Epub 2015 Aug 12 doi: 10.1016/j.imlet.2015.08.003. [Epub ahead of print] PMID: 26277553
Cho S, Lee SH, Park S, Jee SH, Hong MK, Chung N, Cho SY, Jang Y
Acta Cardiol 2015 Apr;70(2):205-10. doi: 10.2143/AC.70.2.3073512. PMID: 26148381
Hou X, Chen X, Shi J
Gene 2015 Jul 1;565(1):39-44. Epub 2015 Mar 31 doi: 10.1016/j.gene.2015.03.062. [Epub ahead of print] PMID: 25839940
Güngör B, Yılmaz H, Ekmekçi A, Özcan KS, Tijani M, Osmonov D, Karataş B, Taha Alper A, Mutluer FO, Gürkan U, Bolca O
J Cardiol 2014 Mar;63(3):223-9. Epub 2013 Sep 21 doi: 10.1016/j.jjcc.2013.08.008. [Epub ahead of print] PMID: 24060526

Therapy

Xu S, Cheng J, Li NH, Chen YN, Cai MY, Tang SS, Huang H, Zhang B, Cen JM, Yang XL, Chen C, Liu X, Xiong XD
Lipids Health Dis 2015 Jun 28;14:63. doi: 10.1186/s12944-015-0065-7. [Epub ahead of print] PMID: 26129832Free PMC Article
Ertelt K, Généreux P, Mintz GS, Brener SJ, Kirtane AJ, McAndrew TC, Francese DP, Ben-Yehuda O, Mehran R, Stone GW
Cardiovasc Revasc Med 2014 Nov-Dec;15(8):375-80. Epub 2014 Sep 16 doi: 10.1016/j.carrev.2014.09.002. [Epub ahead of print] PMID: 25288517
Enas EA, Kuruvila A, Khanna P, Pitchumoni CS, Mohan V
Indian J Med Res 2013 Oct;138(4):461-91. PMID: 24434254Free PMC Article
Vemparala K, Roy A, Bahl VK, Prabhakaran D, Nath N, Sinha S, Nandi P, Pandey RM, Reddy KS, Manhapra A, Lakshmy R
BMC Cardiovasc Disord 2013 Nov 19;13:104. doi: 10.1186/1471-2261-13-104. [Epub ahead of print] PMID: 24245738Free PMC Article
Hong SJ, Chang HJ, Park S, Kang DR, Shin S, Cho IJ, Shim CY, Hong GR, Ha JW, Chung N
Clin Cardiol 2013 Aug;36(8):480-5. Epub 2013 Jun 10 doi: 10.1002/clc.22152. [Epub ahead of print] PMID: 23754711

Prognosis

Abdi-Ali A, Shaheen A, Southern D, Zhang M, Knudtson M, White J, Graham M, James MT, Wilton SB
Am J Cardiol 2016 Feb 1;117(3):353-8. Epub 2015 Nov 18 doi: 10.1016/j.amjcard.2015.11.008. [Epub ahead of print] PMID: 26723106
Marcial JM, Altieri PI
Bol Asoc Med P R 2015 Jul-Sep;107(3):70-4. PMID: 26742200
Mohammad AM, Jehangeer HI, Shaikhow SK
BMC Cardiovasc Disord 2015 Nov 18;15:155. doi: 10.1186/s12872-015-0145-7. [Epub ahead of print] PMID: 26582255Free PMC Article
Cho S, Lee SH, Park S, Jee SH, Hong MK, Chung N, Cho SY, Jang Y
Acta Cardiol 2015 Apr;70(2):205-10. doi: 10.2143/AC.70.2.3073512. PMID: 26148381
Xie F, Chen Z, Ding Z, Ma G
Mol Biol Rep 2013 May;40(5):3649-54. Epub 2012 Dec 25 doi: 10.1007/s11033-012-2440-z. [Epub ahead of print] PMID: 23266671

Clinical prediction guides

Marcial JM, Altieri PI
Bol Asoc Med P R 2015 Jul-Sep;107(3):70-4. PMID: 26742200
Mohammad AM, Jehangeer HI, Shaikhow SK
BMC Cardiovasc Disord 2015 Nov 18;15:155. doi: 10.1186/s12872-015-0145-7. [Epub ahead of print] PMID: 26582255Free PMC Article
Angeles-Martínez J, Posadas-Sánchez R, Álvarez-León E, Villarreal-Molina T, Cardoso-Saldaña G, Fragoso JM, Juárez-Rojas JG, Medina-Urrutia A, Posadas-Romero C, Vargas-Alarcón G
Immunol Lett 2015 Oct;167(2):125-30. Epub 2015 Aug 12 doi: 10.1016/j.imlet.2015.08.003. [Epub ahead of print] PMID: 26277553
Cho S, Lee SH, Park S, Jee SH, Hong MK, Chung N, Cho SY, Jang Y
Acta Cardiol 2015 Apr;70(2):205-10. doi: 10.2143/AC.70.2.3073512. PMID: 26148381
Xie F, Chen Z, Ding Z, Ma G
Mol Biol Rep 2013 May;40(5):3649-54. Epub 2012 Dec 25 doi: 10.1007/s11033-012-2440-z. [Epub ahead of print] PMID: 23266671

Recent systematic reviews

Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, Ose L, Averna M, Boileau C, Borén J, Bruckert E, Catapano AL, Defesche JC, Descamps OS, Hegele RA, Hovingh GK, Humphries SE, Kovanen PT, Kuivenhoven JA, Masana L, Nordestgaard BG, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Steinhagen-Thiessen E, Stroes ES, Taskinen MR, Tybjærg-Hansen A, Wiklund O; European Atherosclerosis Society Consensus Panel
Eur Heart J 2015 Sep 21;36(36):2425-37. Epub 2015 May 25 doi: 10.1093/eurheartj/ehv157. [Epub ahead of print] PMID: 26009596Free PMC Article
Hou X, Chen X, Shi J
Gene 2015 Jul 1;565(1):39-44. Epub 2015 Mar 31 doi: 10.1016/j.gene.2015.03.062. [Epub ahead of print] PMID: 25839940
Kirke AB, Barbour RA, Burrows S, Bell DA, Vickery AW, Emery J, Watts GF
Heart Lung Circ 2015 Mar;24(3):250-6. Epub 2014 Sep 30 doi: 10.1016/j.hlc.2014.09.011. [Epub ahead of print] PMID: 25445428
Bosch N, Frishman WH
Cardiol Rev 2014 Jan-Feb;22(1):17-24. doi: 10.1097/CRD.0b013e31829cac29. PMID: 23707991
Rader DJ, Hoeg JM, Brewer HB Jr
Ann Intern Med 1994 Jun 15;120(12):1012-25. PMID: 8185133

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