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Extensively drug-resistant tuberculosis

MedGen UID:
321809
•Concept ID:
C1827301
•
Disease or Syndrome
Synonyms: Drug-Resistant Tuberculoses, Extensively; Drug-Resistant Tuberculoses, Extremely; Drug-Resistant Tuberculosis, Extensively; Drug-Resistant Tuberculosis, Extremely; Extensively Drug Resistant Tuberculosis; Extensively Drug-Resistant Tuberculoses; Extensively Drug-Resistant Tuberculosis; Extremely Drug Resistant Tuberculosis; Extremely Drug-Resistant Tuberculoses; Extremely Drug-Resistant Tuberculosis; Tuberculoses, Extensively Drug-Resistant; Tuberculoses, Extremely Drug-Resistant; Tuberculosis, Extensively Drug Resistant; Tuberculosis, Extensively Drug-Resistant; Tuberculosis, Extremely Drug Resistant; Tuberculosis, Extremely Drug-Resistant; XDR-TB
SNOMED CT: Extreme drug resistant tuberculosis (422481005); Extremely drug resistant tuberculosis (422481005); Extensively drug resistant tuberculosis (710106005)
 
Monarch Initiative: MONDO:0100482

Definition

Extensively drug resistant TB are strains of TB that are resistant to at least rifampicin and isoniazid, and also resistant to a fluoroquinolone and to at least one of the three injectable TB drugs, capreomycin, kanamycin and amikacin. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtensively drug-resistant tuberculosis

Professional guidelines

PubMed

Update of drug-resistant tuberculosis treatment guidelines: A turning point.
Vanino E, Granozzi B, Akkerman OW, Munoz-Torrico M, Palmieri F, Seaworth B, Tiberi S, Tadolini M
Int J Infect Dis 2023 May;130 Suppl 1:S12-S15. Epub 2023 Mar 12 doi: 10.1016/j.ijid.2023.03.013. PMID: 36918080
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Treatment of Tuberculosis. A Historical Perspective.
Murray JF, Schraufnagel DE, Hopewell PC
Ann Am Thorac Soc 2015 Dec;12(12):1749-59. doi: 10.1513/AnnalsATS.201509-632PS. PMID: 26653188

Recent clinical studies

Etiology

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.
Migliori GB, Tiberi S, Zumla A, Petersen E, Chakaya JM, Wejse C, Muñoz Torrico M, Duarte R, Alffenaar JW, Schaaf HS, Marais BJ, Cirillo DM, Alagna R, Rendon A, Pontali E, Piubello A, Figueroa J, Ferlazzo G, García-Basteiro A, Centis R, Visca D, D'Ambrosio L, Sotgiu G; members of the Global Tuberculosis Network
Int J Infect Dis 2020 Mar;92S:S15-S25. Epub 2020 Feb 4 doi: 10.1016/j.ijid.2020.01.042. PMID: 32032752
Epidemiology of Drug-Resistant Tuberculosis.
Dean AS, Cox H, Zignol M
Adv Exp Med Biol 2017;1019:209-220. doi: 10.1007/978-3-319-64371-7_11. PMID: 29116637
Therapeutic drug monitoring in the treatment of tuberculosis: an update.
Alsultan A, Peloquin CA
Drugs 2014 Jun;74(8):839-54. doi: 10.1007/s40265-014-0222-8. PMID: 24846578

Diagnosis

Multidrug-resistant tuberculosis.
Dheda K, Mirzayev F, Cirillo DM, Udwadia Z, Dooley KE, Chang KC, Omar SV, Reuter A, Perumal T, Horsburgh CR Jr, Murray M, Lange C
Nat Rev Dis Primers 2024 Mar 24;10(1):22. doi: 10.1038/s41572-024-00504-2. PMID: 38523140
Drug resistant TB - latest developments in epidemiology, diagnostics and management.
Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines.
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article
Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis.
Seung KJ, Keshavjee S, Rich ML
Cold Spring Harb Perspect Med 2015 Apr 27;5(9):a017863. doi: 10.1101/cshperspect.a017863. PMID: 25918181Free PMC Article

Therapy

Drug resistant TB - latest developments in epidemiology, diagnostics and management.
Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines.
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article
Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis.
Seung KJ, Keshavjee S, Rich ML
Cold Spring Harb Perspect Med 2015 Apr 27;5(9):a017863. doi: 10.1101/cshperspect.a017863. PMID: 25918181Free PMC Article
Therapeutic drug monitoring in the treatment of tuberculosis: an update.
Alsultan A, Peloquin CA
Drugs 2014 Jun;74(8):839-54. doi: 10.1007/s40265-014-0222-8. PMID: 24846578

Prognosis

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Therapy of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis.
Seaworth BJ, Griffith DE
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0042-2017. PMID: 28361737
Multidrug and extensively drug-resistant tuberculosis.
Maitre T, Aubry A, Jarlier V, Robert J, Veziris N; CNR-MyRMA
Med Mal Infect 2017 Feb;47(1):3-10. doi: 10.1016/j.medmal.2016.07.006. PMID: 27637852
Treatment of Tuberculosis. A Historical Perspective.
Murray JF, Schraufnagel DE, Hopewell PC
Ann Am Thorac Soc 2015 Dec;12(12):1749-59. doi: 10.1513/AnnalsATS.201509-632PS. PMID: 26653188

Clinical prediction guides

Global treatment outcomes of extensively drug-resistant tuberculosis in adults: A systematic review and meta-analysis.
Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, Lillebaek T, Andersen AB, Wejse CM, Dahl VN
J Infect 2023 Sep;87(3):177-189. Epub 2023 Jun 23 doi: 10.1016/j.jinf.2023.06.014. PMID: 37356629
Drug resistant TB - latest developments in epidemiology, diagnostics and management.
Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838

Recent systematic reviews

Global treatment outcomes of extensively drug-resistant tuberculosis in adults: A systematic review and meta-analysis.
Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, Lillebaek T, Andersen AB, Wejse CM, Dahl VN
J Infect 2023 Sep;87(3):177-189. Epub 2023 Jun 23 doi: 10.1016/j.jinf.2023.06.014. PMID: 37356629
Epidemiology of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: A systematic review and meta-analysis.
Diriba G, Alemu A, Yenew B, Tola HH, Gamtesa DF, Mollalign H, Eshetu K, Moga S, Abdella S, Tollera G, Kebede A, Dangisso MH
Int J Infect Dis 2023 Jul;132:50-63. Epub 2023 Apr 16 doi: 10.1016/j.ijid.2023.04.392. PMID: 37072053Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
A systemic review on tuberculosis.
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856
Prevalence of drug-resistant pulmonary tuberculosis in India: systematic review and meta-analysis.
Goyal V, Kadam V, Narang P, Singh V
BMC Public Health 2017 Oct 17;17(1):817. doi: 10.1186/s12889-017-4779-5. PMID: 29041901Free PMC Article

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