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Ligand Binding

MedGen UID:
309303
•Concept ID:
C1517880
•
Molecular Function

Definition

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that ordinarily results in modification of its function, e.g., antigen-antibody binding, hormone- or neurotransmitter-receptor binding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLigand Binding

Professional guidelines

PubMed

Targeting HER3 for cancer treatment: a new horizon for an old target.
Uliano J, Corvaja C, Curigliano G, Tarantino P
ESMO Open 2023 Feb;8(1):100790. Epub 2023 Feb 8 doi: 10.1016/j.esmoop.2023.100790. PMID: 36764093Free PMC Article
Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders.
Roskoski R Jr
Pharmacol Res 2022 Sep;183:106362. Epub 2022 Jul 22 doi: 10.1016/j.phrs.2022.106362. PMID: 35878738
GRIN2A-related disorders: genotype and functional consequence predict phenotype.
Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group
Brain 2019 Jan 1;142(1):80-92. doi: 10.1093/brain/awy304. PMID: 30544257Free PMC Article

Recent clinical studies

Etiology

A look at ligand binding thermodynamics in drug discovery.
Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A
Expert Opin Drug Discov 2017 Apr;12(4):363-377. Epub 2017 Mar 1 doi: 10.1080/17460441.2017.1297418. PMID: 28276703
Protonation and pK changes in protein-ligand binding.
Onufriev AV, Alexov E
Q Rev Biophys 2013 May;46(2):181-209. doi: 10.1017/S0033583513000024. PMID: 23889892Free PMC Article
Pharmacophore-based virtual screening.
Horvath D
Methods Mol Biol 2011;672:261-98. doi: 10.1007/978-1-60761-839-3_11. PMID: 20838973
Permissive geometry model.
Minguet S, Schamel WW
Adv Exp Med Biol 2008;640:113-20. doi: 10.1007/978-0-387-09789-3_11. PMID: 19065789
Clustering models.
Schamel WW, Reth M
Adv Exp Med Biol 2008;640:64-73. doi: 10.1007/978-0-387-09789-3_6. PMID: 19065784

Diagnosis

Stability-based approaches in chemoproteomics.
George AL, Dueñas ME, Marín-Rubio JL, Trost M
Expert Rev Mol Med 2024 Apr 12;26:e6. doi: 10.1017/erm.2024.6. PMID: 38604802
High-throughput methods in aptamer discovery and analysis.
Cole KH, Lupták A
Methods Enzymol 2019;621:329-346. Epub 2019 Mar 12 doi: 10.1016/bs.mie.2019.02.009. PMID: 31128787
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.
Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S
Nat Genet 2013 Dec;45(12):1439-45. Epub 2013 Nov 3 doi: 10.1038/ng.2822. PMID: 24185512Free PMC Article
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
Oakley RH, Cidlowski JA
J Allergy Clin Immunol 2013 Nov;132(5):1033-44. Epub 2013 Sep 29 doi: 10.1016/j.jaci.2013.09.007. PMID: 24084075Free PMC Article
Protein microarray technology.
Stoll D, Templin MF, Schrenk M, Traub PC, Vöhringer CF, Joos TO
Front Biosci 2002 Jan 1;7:c13-32. doi: 10.2741/stoll. PMID: 11779717

Therapy

Targeting HER3 for cancer treatment: a new horizon for an old target.
Uliano J, Corvaja C, Curigliano G, Tarantino P
ESMO Open 2023 Feb;8(1):100790. Epub 2023 Feb 8 doi: 10.1016/j.esmoop.2023.100790. PMID: 36764093Free PMC Article
Telitacicept as a BLyS/APRIL dual inhibitor for autoimmune disease.
Shi F, Xue R, Zhou X, Shen P, Wang S, Yang Y
Immunopharmacol Immunotoxicol 2021 Dec;43(6):666-673. Epub 2021 Sep 14 doi: 10.1080/08923973.2021.1973493. PMID: 34519594
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M
J Exp Med 2020 Sep 7;217(9) doi: 10.1084/jem.20200785. PMID: 32579671Free PMC Article
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.
Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S
Nat Genet 2013 Dec;45(12):1439-45. Epub 2013 Nov 3 doi: 10.1038/ng.2822. PMID: 24185512Free PMC Article
Aluminium, antiperspirants and breast cancer.
Darbre PD
J Inorg Biochem 2005 Sep;99(9):1912-9. doi: 10.1016/j.jinorgbio.2005.06.001. PMID: 16045991

Prognosis

The Perturbed Free-Energy Landscape: Linking Ligand Binding to Biomolecular Folding.
Abdelsattar AS, Mansour Y, Aboul-Ela F
Chembiochem 2021 May 4;22(9):1499-1516. Epub 2021 Feb 10 doi: 10.1002/cbic.202000695. PMID: 33351206
Serum Albumin, Lipid and Drug Binding.
Nishi K, Yamasaki K, Otagiri M
Subcell Biochem 2020;94:383-397. doi: 10.1007/978-3-030-41769-7_15. PMID: 32189308
Alternative retinoid X receptor (RXR) ligands.
Krężel W, Rühl R, de Lera AR
Mol Cell Endocrinol 2019 Jul 1;491:110436. Epub 2019 Apr 23 doi: 10.1016/j.mce.2019.04.016. PMID: 31026478
Protonation and pK changes in protein-ligand binding.
Onufriev AV, Alexov E
Q Rev Biophys 2013 May;46(2):181-209. doi: 10.1017/S0033583513000024. PMID: 23889892Free PMC Article
Pharmacophore-based virtual screening.
Horvath D
Methods Mol Biol 2011;672:261-98. doi: 10.1007/978-1-60761-839-3_11. PMID: 20838973

Clinical prediction guides

Covalent ligands of nuclear receptors.
Rajan S, Yoon HS
Eur J Med Chem 2023 Dec 5;261:115869. Epub 2023 Oct 11 doi: 10.1016/j.ejmech.2023.115869. PMID: 37857142
Serum Albumin, Lipid and Drug Binding.
Nishi K, Yamasaki K, Otagiri M
Subcell Biochem 2020;94:383-397. doi: 10.1007/978-3-030-41769-7_15. PMID: 32189308
Ligand Binding and Signaling of HARE/Stabilin-2.
Harris EN, Cabral F
Biomolecules 2019 Jul 11;9(7) doi: 10.3390/biom9070273. PMID: 31336723Free PMC Article
Pharmacophore-based virtual screening.
Horvath D
Methods Mol Biol 2011;672:261-98. doi: 10.1007/978-1-60761-839-3_11. PMID: 20838973
Permissive geometry model.
Minguet S, Schamel WW
Adv Exp Med Biol 2008;640:113-20. doi: 10.1007/978-0-387-09789-3_11. PMID: 19065789

Recent systematic reviews

Detection of anti-androgenic activity of chemicals in fish studies: a data review.
Panter GH, Brown RJ, Jones A, Körner O, Lagadic L, Weltje L
Crit Rev Toxicol 2023 May;53(5):326-338. Epub 2023 Aug 1 doi: 10.1080/10408444.2023.2232398. PMID: 37526219
A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma.
Miyagishima DF, Sundaresan V, Gutierrez AG, Barak T, Yeung J, Moliterno J, McGuone D, Claus EB, Günel M
J Neurosurg 2023 Dec 1;139(6):1638-1647. Epub 2023 May 26 doi: 10.3171/2023.3.JNS221838. PMID: 37243565Free PMC Article
Genotypic Spectrum and its Correlation with Alopecia and Clinical Response in Hereditary Vitamin D Resistant Rickets: Our Experience and Systematic Review.
Dodamani MH, Lila AR, Memon SS, Sarathi V, Arya S, Rane A, Sehemby MK, Garg R, Bhandare VV, Karlekar M, Patil VA, Kunwar A, Bandgar TR
Calcif Tissue Int 2023 Apr;112(4):483-492. Epub 2023 Jan 27 doi: 10.1007/s00223-023-01061-8. PMID: 36705686
The association between type of endocrine therapy and development of estrogen receptor-1 mutation(s) in patients with hormone-sensitive advanced breast cancer: A systematic review and meta-analysis of randomized and non-randomized trials.
Najim O, Seghers S, Sergoynne L, Van Gaver H, Papadimitriou K, Wouters K, Trinh XB, Huizing MT, Tjalma W
Biochim Biophys Acta Rev Cancer 2019 Dec;1872(2):188315. Epub 2019 Oct 21 doi: 10.1016/j.bbcan.2019.188315. PMID: 31647985
Association of RAGE gene Gly82Ser polymorphism with coronary artery disease and ischemic stroke: A systematic review and meta-analysis.
Ma WQ, Qu QR, Zhao Y, Liu NF
Medicine (Baltimore) 2016 Dec;95(49):e5593. doi: 10.1097/MD.0000000000005593. PMID: 27930580Free PMC Article

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