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Grade 3 Weight Loss, CTCAE

MedGen UID:
293133
•Concept ID:
C1559080
•
Finding

Definition

>=20% from baseline; tube feeding or TPN indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Weight Loss, CTCAE

Professional guidelines

PubMed

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Changes in body weight and serum liver tests associated with parenteral nutrition compared with no parenteral nutrition in patients with acute myeloid leukemia during remission induction treatment.
van Lieshout R, Tick LW, Dieleman JP, Custers S, van Dongen MS, van der Lee D, Schaaphok AR, Snellen M, Schouten HC, Beijer S
Support Care Cancer 2020 Sep;28(9):4381-4393. Epub 2020 Jan 8 doi: 10.1007/s00520-019-05251-9. PMID: 31916008
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Recent clinical studies

Etiology

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Diagnosis

The effect of amino acid-oral rehydration solution (Enterade®) on chemotherapy related diarrhea and quality of life in solid tumor cancer patients: A non-randomized experimental study.
Chitwood H, Hampton D, Patel R
Eur J Oncol Nurs 2022 Oct;60:102186. Epub 2022 Aug 2 doi: 10.1016/j.ejon.2022.102186. PMID: 35970073
Low lean mass and chemotherapy toxicity risk in the elderly: the Fraction study protocol.
Steinmeyer Z, Gérard S, Filleron T, Lozano S, Brechemier D, Abellan Van Kan G, Mourey L, Cristol-Dalstein L, De Decker L, Rolland Y, Balardy L
BMC Cancer 2019 Nov 27;19(1):1153. doi: 10.1186/s12885-019-6377-7. PMID: 31775667Free PMC Article
A randomized phase II/III study of adverse events between sequential (SEQ) versus simultaneous integrated boost (SIB) intensity modulated radiation therapy (IMRT) in nasopharyngeal carcinoma; preliminary result on acute adverse events.
Songthong AP, Kannarunimit D, Chakkabat C, Lertbutsayanukul C
Radiat Oncol 2015 Aug 8;10:166. doi: 10.1186/s13014-015-0472-y. PMID: 26253488Free PMC Article
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Efficacy and tolerability of vemurafenib in patients with BRAF(V600E) -positive papillary thyroid cancer: M.D. Anderson Cancer Center off label experience.
Dadu R, Shah K, Busaidy NL, Waguespack SG, Habra MA, Ying AK, Hu MI, Bassett R, Jimenez C, Sherman SI, Cabanillas ME
J Clin Endocrinol Metab 2015 Jan;100(1):E77-81. doi: 10.1210/jc.2014-2246. PMID: 25353071Free PMC Article

Therapy

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity.
Iwata H, Toshito T, Hayashi K, Yamada M, Omachi C, Nakajima K, Hattori Y, Hashimoto S, Kuroda Y, Okumura Y, Mizoe JE, Ogino H, Shibamoto Y
J Radiat Res 2019 Oct 23;60(5):612-621. doi: 10.1093/jrr/rrz036. PMID: 31147697Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Prognosis

Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Clinical prediction guides

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

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    Practice guidelines

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