U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Low-Frequency Microsatellite Instability

MedGen UID:
276496
•Concept ID:
C1518003
•
Cell or Molecular Dysfunction
Synonym: Microsatellite Instability Low

Definition

Genomic instability associated with the presence of hypermutation either in one microsatellite instability (MSI) marker or in between 10 and 30 percent of the MSI markers in a tumor sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow-Frequency Microsatellite Instability

Professional guidelines

PubMed

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer.
Álvaro E, Cano JM, García JL, Brandáriz L, Olmedillas-López S, Arriba M, Rueda D, Rodríguez Y, Cañete Á, Arribas J, Inglada-Pérez L, Pérez J, Gómez C, García-Arranz M, García-Olmo D, Goel A, Urioste M, González-Sarmiento R, Perea J
Int J Mol Sci 2019 Feb 22;20(4) doi: 10.3390/ijms20040968. PMID: 30813366Free PMC Article
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S
Cancer Res 1998 Nov 15;58(22):5248-57. PMID: 9823339
Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations.
Wijnen J, Khan PM, Vasen H, van der Klift H, Mulder A, van Leeuwen-Cornelisse I, Bakker B, Losekoot M, Møller P, Fodde R
Am J Hum Genet 1997 Aug;61(2):329-35. doi: 10.1086/514847. PMID: 9311737Free PMC Article

Recent clinical studies

Etiology

A radiomics model fusing clinical features to predict microsatellite status preoperatively in colorectal cancer liver metastasis.
Wang X, Liu Z, Yin X, Yang C, Zhang J
BMC Gastroenterol 2023 Sep 12;23(1):308. doi: 10.1186/s12876-023-02922-0. PMID: 37700238Free PMC Article
Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer.
Chen YJ, Guo X, Liu ML, Yu YY, Cui YH, Shen XZ, Liu TS, Liang L
Front Immunol 2022;13:979521. Epub 2022 Dec 7 doi: 10.3389/fimmu.2022.979521. PMID: 36569910Free PMC Article
Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer.
Nakayama Y, Iijima T, Wakaume R, Takahashi K, Matsumoto H, Nakano D, Miyaki M, Yamaguchi T
PLoS One 2019;14(4):e0215513. Epub 2019 Apr 19 doi: 10.1371/journal.pone.0215513. PMID: 31002690Free PMC Article
Clinical implications of microsatellite instability in T1 colorectal cancer.
Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
Yonsei Med J 2015 Jan;56(1):175-81. doi: 10.3349/ymj.2015.56.1.175. PMID: 25510762Free PMC Article
Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737

Diagnosis

Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737
Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.
Cleary SP, Cotterchio M, Jenkins MA, Kim H, Bristow R, Green R, Haile R, Hopper JL, LeMarchand L, Lindor N, Parfrey P, Potter J, Younghusband B, Gallinger S
Gastroenterology 2009 Apr;136(4):1251-60. Epub 2008 Dec 27 doi: 10.1053/j.gastro.2008.12.050. PMID: 19245865Free PMC Article
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.
Yuen ST, Chan TL, Ho JW, Chan AS, Chung LP, Lam PW, Tse CW, Wyllie AH, Leung SY
Oncogene 2002 Oct 24;21(49):7585-92. doi: 10.1038/sj.onc.1205968. PMID: 12386821

Therapy

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, Hamilton SR, Laurent-Puig P, Gryfe R, Shepherd LE, Tu D, Redston M, Gallinger S
N Engl J Med 2003 Jul 17;349(3):247-57. doi: 10.1056/NEJMoa022289. PMID: 12867608Free PMC Article

Prognosis

A radiomics model fusing clinical features to predict microsatellite status preoperatively in colorectal cancer liver metastasis.
Wang X, Liu Z, Yin X, Yang C, Zhang J
BMC Gastroenterol 2023 Sep 12;23(1):308. doi: 10.1186/s12876-023-02922-0. PMID: 37700238Free PMC Article
Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer.
Chen YJ, Guo X, Liu ML, Yu YY, Cui YH, Shen XZ, Liu TS, Liang L
Front Immunol 2022;13:979521. Epub 2022 Dec 7 doi: 10.3389/fimmu.2022.979521. PMID: 36569910Free PMC Article
Clinical implications of microsatellite instability in T1 colorectal cancer.
Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
Yonsei Med J 2015 Jan;56(1):175-81. doi: 10.3349/ymj.2015.56.1.175. PMID: 25510762Free PMC Article
Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, Hamilton SR, Laurent-Puig P, Gryfe R, Shepherd LE, Tu D, Redston M, Gallinger S
N Engl J Med 2003 Jul 17;349(3):247-57. doi: 10.1056/NEJMoa022289. PMID: 12867608Free PMC Article

Clinical prediction guides

A radiomics model fusing clinical features to predict microsatellite status preoperatively in colorectal cancer liver metastasis.
Wang X, Liu Z, Yin X, Yang C, Zhang J
BMC Gastroenterol 2023 Sep 12;23(1):308. doi: 10.1186/s12876-023-02922-0. PMID: 37700238Free PMC Article
Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer.
Chen YJ, Guo X, Liu ML, Yu YY, Cui YH, Shen XZ, Liu TS, Liang L
Front Immunol 2022;13:979521. Epub 2022 Dec 7 doi: 10.3389/fimmu.2022.979521. PMID: 36569910Free PMC Article
Clinical implications of microsatellite instability in T1 colorectal cancer.
Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
Yonsei Med J 2015 Jan;56(1):175-81. doi: 10.3349/ymj.2015.56.1.175. PMID: 25510762Free PMC Article
Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, Hamilton SR, Laurent-Puig P, Gryfe R, Shepherd LE, Tu D, Redston M, Gallinger S
N Engl J Med 2003 Jul 17;349(3):247-57. doi: 10.1056/NEJMoa022289. PMID: 12867608Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...