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Skin basaloid carcinoma

MedGen UID:
233446
•Concept ID:
C1335973
•
Neoplastic Process
Synonyms: Basaloid Skin Squamous Cell Carcinoma; basaloid skin squamous cell carcinoma; basaloid squamous cell skin carcinoma; Skin Basaloid Carcinoma; skin basaloid carcinoma; Skin Basaloid Squamous Cell Carcinoma; skin basaloid squamous cell carcinoma; zone of skin basaloid squamous cell carcinoma
 
Monarch Initiative: MONDO:0004091

Definition

An aggressive variant of skin squamous cell carcinoma. It is characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin basaloid carcinoma

Professional guidelines

PubMed

Penile intraepithelial neoplasia: Distribution of subtypes, HPV genotypes and p16(INK4a) in 84 international cases.
Fernández-Nestosa MJ, Clavero O, Sánchez DF, Giannico GA, Lobatti A, Cañete-Portillo S, Velázquez EF, Alemany L, Muñoz N, de San José S, Bosch FX, Cubilla AL
Hum Pathol 2023 Jan;131:1-8. Epub 2022 Nov 24 doi: 10.1016/j.humpath.2022.11.006. PMID: 36427594
Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment.
Shukla S, Khachemoune A
Arch Dermatol Res 2020 Nov;312(9):605-609. Epub 2020 Mar 12 doi: 10.1007/s00403-020-02058-1. PMID: 32166375
Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens.
Swanson PE, Fitzpatrick MM, Ritter JH, Glusac EJ, Wick MR
J Cutan Pathol 1998 Mar;25(3):153-9. doi: 10.1111/j.1600-0560.1998.tb01708.x. PMID: 9550314

Recent clinical studies

Etiology

Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series.
Straub Hogan MM, Spieker AJ, Orejudos M, Gheit T, Herfs M, Tommasino M, Sanchez DF, Fernandez-Nestosa MJ, Pena MDCR, Gordetsky JB, Epstein JI, Canete-Portillo S, Gellert LL, Prieto Granada CN, Magi-Galluzzi C, Cubilla AL, Giannico GA
Mod Pathol 2022 Aug;35(8):1101-1109. Epub 2022 Feb 21 doi: 10.1038/s41379-022-01020-y. PMID: 35190664
Extraocular Sebaceous Carcinoma-A Clinicopathologic Reassessment.
Candelario NM, Sánchez JE, Sánchez JL, Martín-García RF, Rochet NM
Am J Dermatopathol 2016 Nov;38(11):809-812. doi: 10.1097/DAD.0000000000000591. PMID: 27763901
Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis.
Herrmann JL, Allan A, Trapp KM, Morgan MB
J Am Acad Dermatol 2014 Jul;71(1):38-43.e2. Epub 2014 Apr 13 doi: 10.1016/j.jaad.2014.02.042. PMID: 24739254
Basaloid squamous cell carcinoma of the skin.
Boyd AS, Stasko TS, Tang YW
J Am Acad Dermatol 2011 Jan;64(1):144-51. doi: 10.1016/j.jaad.2010.02.051. PMID: 21167410
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Diagnosis

Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Fibroepithelioma of Pinkus.
Bartos V, Pokorny D, Zacharova O, Kullova M, Adamicova K, Pec M
Bratisl Lek Listy 2012;113(10):624-7. doi: 10.4149/bll_2012_142. PMID: 23094905
Basaloid follicular hamartoma.
Mills O, Thomas LB
Arch Pathol Lab Med 2010 Aug;134(8):1215-9. doi: 10.5858/2008-0620-RS.1. PMID: 20670146
Desmoplastic seborrheic keratosis.
King R, Page RN, Googe PB
Am J Dermatopathol 2003 Jun;25(3):210-4. doi: 10.1097/00000372-200306000-00005. PMID: 12775983
Leser-Trelat sign.
Ceylan C, Alper S, Kilinç I
Int J Dermatol 2002 Oct;41(10):687-8. doi: 10.1046/j.1365-4362.2002.01600.x. PMID: 12390193

Therapy

Differentiation and risk stratification of basal cell carcinoma with deep learning on histopathologic images and measuring nuclei and tumor microenvironment features.
Lan X, Guo G, Wang X, Yan Q, Xue R, Li Y, Zhu J, Dong Z, Wang F, Li G, Wang X, Xu J, Jiang Y
Skin Res Technol 2024 Jan;30(1):e13571. doi: 10.1111/srt.13571. PMID: 38196164Free PMC Article
Perianal basal cell carcinoma managed with wide excision and random flap reconstruction.
Lim MGL, Lopez MPJ, Yu JAO, Albaño JPP
BMJ Case Rep 2022 Jun 20;15(6) doi: 10.1136/bcr-2022-250493. PMID: 35725283Free PMC Article
Association of Smoking and Other Factors With the Outcome of Mohs Reconstruction Using Flaps or Grafts.
Wang CY, Dudzinski J, Nguyen D, Armbrecht E, Maher IA
JAMA Facial Plast Surg 2019 Sep 1;21(5):407-413. doi: 10.1001/jamafacial.2019.0243. PMID: 31194217Free PMC Article
Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary results.
Mevio N, Bertino G, Occhini A, Scelsi D, Tagliabue M, Mura F, Benazzo M
Tumori 2012 May-Jun;98(3):308-13. doi: 10.1177/030089161209800305. PMID: 22825505
Pathologic changes after photodynamic therapy for Basal cell carcinoma and Bowen disease: a histologic and immunohistochemical investigation.
Fantini F, Greco A, Cesinaro AM, Surrenti T, Peris K, Vaschieri C, Marconi A, Giannetti A, Pincelli C
Arch Dermatol 2008 Feb;144(2):186-94. doi: 10.1001/archdermatol.2007.31. PMID: 18283175

Prognosis

Ocular sebaceous gland carcinoma: an update of the literature.
Cicinelli MV, Kaliki S
Int Ophthalmol 2019 May;39(5):1187-1197. Epub 2018 Apr 25 doi: 10.1007/s10792-018-0925-z. PMID: 29696467
Role of Human Papillomavirus in Vulvar Cancer.
Rakislova N, Saco A, Sierra A, Del Pino M, Ordi J
Adv Anat Pathol 2017 Jul;24(4):201-214. doi: 10.1097/PAP.0000000000000155. PMID: 28590952
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Fibroepithelioma of Pinkus.
Bartos V, Pokorny D, Zacharova O, Kullova M, Adamicova K, Pec M
Bratisl Lek Listy 2012;113(10):624-7. doi: 10.4149/bll_2012_142. PMID: 23094905
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Clinical prediction guides

Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
Gill P, Naugler C, Abi Daoud MS
Appl Immunohistochem Mol Morphol 2019 Sep;27(8):584-588. doi: 10.1097/PAI.0000000000000664. PMID: 29629953
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal.
Webb DV, Mentrikoski MJ, Verduin L, Brill LB 2nd, Wick MR
Ann Diagn Pathol 2015 Apr;19(2):70-5. Epub 2015 Jan 22 doi: 10.1016/j.anndiagpath.2015.01.004. PMID: 25702956
Fibroepithelioma of Pinkus.
Bartos V, Pokorny D, Zacharova O, Kullova M, Adamicova K, Pec M
Bratisl Lek Listy 2012;113(10):624-7. doi: 10.4149/bll_2012_142. PMID: 23094905
Leser-Trelat sign.
Ceylan C, Alper S, Kilinç I
Int J Dermatol 2002 Oct;41(10):687-8. doi: 10.1046/j.1365-4362.2002.01600.x. PMID: 12390193

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