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Diencephalic Glioblastoma

MedGen UID:
232424
•Concept ID:
C1333285
•
Neoplastic Process

Definition

A glioblastoma that occurs in the diencephalon. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiencephalic Glioblastoma

Professional guidelines

PubMed

Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

Recent clinical studies

Etiology

Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.
Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK
Brain Pathol 2015 Jul;25(4):429-40. Epub 2015 Jan 27 doi: 10.1111/bpa.12239. PMID: 25521223Free PMC Article
Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Ultrasonic contrast agents in transcranial perfusion sonography (TPS) for follow-up of patients with high grade gliomas.
Ickenstein GW, Valaikiene J, Koch H, Hau P, Erban P, Schlachetzki F
Ultrason Sonochem 2008 Apr;15(4):510-516. Epub 2007 Sep 14 doi: 10.1016/j.ultsonch.2007.08.009. PMID: 18029220
Stereotactic interstitial irradiation of diencephalic tumors with iridium 192 and iodine 125: 10 years follow-up and comparison with other treatments.
Etou A, Mundinger F, Mohadjer M, Birg W
Childs Nerv Syst 1989 Jun;5(3):140-3. doi: 10.1007/BF00272114. PMID: 2547523

Diagnosis

Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.
Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK
Brain Pathol 2015 Jul;25(4):429-40. Epub 2015 Jan 27 doi: 10.1111/bpa.12239. PMID: 25521223Free PMC Article
Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Survival and late effects on development of patients with infantile brain tumor.
Nomura Y, Yasumoto S, Yanai F, Akiyoshi H, Inoue T, Nibu K, Tsugu H, Fukushima T, Hirose S
Pediatr Int 2009 Jun;51(3):337-41. Epub 2008 Dec 29 doi: 10.1111/j.1442-200X.2008.02760.x. PMID: 19400825
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

Therapy

Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Stereotactic interstitial irradiation of diencephalic tumors with iridium 192 and iodine 125: 10 years follow-up and comparison with other treatments.
Etou A, Mundinger F, Mohadjer M, Birg W
Childs Nerv Syst 1989 Jun;5(3):140-3. doi: 10.1007/BF00272114. PMID: 2547523
Interstitial radioisotope therapy of intractable diencephalic tumors by the stereotaxic permanent implantation of iridium192, including bioptic control.
Mundinger F, Metzel E
Confin Neurol 1970;32(2):195-202. doi: 10.1159/000103415. PMID: 4323068

Prognosis

Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.
Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK
Brain Pathol 2015 Jul;25(4):429-40. Epub 2015 Jan 27 doi: 10.1111/bpa.12239. PMID: 25521223Free PMC Article
Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Survival and late effects on development of patients with infantile brain tumor.
Nomura Y, Yasumoto S, Yanai F, Akiyoshi H, Inoue T, Nibu K, Tsugu H, Fukushima T, Hirose S
Pediatr Int 2009 Jun;51(3):337-41. Epub 2008 Dec 29 doi: 10.1111/j.1442-200X.2008.02760.x. PMID: 19400825
Ultrasonic contrast agents in transcranial perfusion sonography (TPS) for follow-up of patients with high grade gliomas.
Ickenstein GW, Valaikiene J, Koch H, Hau P, Erban P, Schlachetzki F
Ultrason Sonochem 2008 Apr;15(4):510-516. Epub 2007 Sep 14 doi: 10.1016/j.ultsonch.2007.08.009. PMID: 18029220
Stereotactic interstitial irradiation of diencephalic tumors with iridium 192 and iodine 125: 10 years follow-up and comparison with other treatments.
Etou A, Mundinger F, Mohadjer M, Birg W
Childs Nerv Syst 1989 Jun;5(3):140-3. doi: 10.1007/BF00272114. PMID: 2547523

Clinical prediction guides

Potential role for valproate in the treatment of high--risk brain tumors of childhood-results from a retrospective observational cohort study.
Felix FH, Trompieri NM, de Araujo OL, da Trindade KM, Fontenele JB
Pediatr Hematol Oncol 2011 Oct;28(7):556-70. Epub 2011 Jun 24 doi: 10.3109/08880018.2011.563774. PMID: 21699466
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Survival and late effects on development of patients with infantile brain tumor.
Nomura Y, Yasumoto S, Yanai F, Akiyoshi H, Inoue T, Nibu K, Tsugu H, Fukushima T, Hirose S
Pediatr Int 2009 Jun;51(3):337-41. Epub 2008 Dec 29 doi: 10.1111/j.1442-200X.2008.02760.x. PMID: 19400825
Bimedial rectus hypermetabolism in convergence spasm as observed on positron emission tomography.
Jeong SH, Oh YM, Kim CY, Kim JS
J Neuroophthalmol 2008 Sep;28(3):217-8. doi: 10.1097/WNO.0b013e3181772b02. PMID: 18769288
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

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