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High Grade Cervical Intraepithelial Neoplasia

MedGen UID:
232286
•Concept ID:
C1334011
•
Neoplastic Process

Definition

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes. [from NCI]

Professional guidelines

PubMed

Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review.
Bonde J, Bottari F, Iacobone AD, Cocuzza CE, Sandri MT, Bogliatto F, Khan KS, Ejegod DM, Gary DS, Andrews JC
J Low Genit Tract Dis 2021 Jan 1;25(1):27-37. doi: 10.1097/LGT.0000000000000573. PMID: 33105450Free PMC Article
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708

Recent clinical studies

Etiology

Characteristics of vaginal microbiota in various cervical intraepithelial neoplasia: a cross-sectional study.
Liu Y, Wang S, Liu J, Su M, Diao X, Liang X, Zhang J, Wang Q, Zhan Y
J Transl Med 2023 Nov 16;21(1):816. doi: 10.1186/s12967-023-04676-5. PMID: 37974192Free PMC Article
Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States.
Bukowski A, Hoyo C, Vielot NA, Graff M, Kosorok MR, Brewster WR, Maguire RL, Murphy SK, Nedjai B, Ladoukakis E, North KE, Smith JS
BMC Cancer 2023 Nov 6;23(1):1072. doi: 10.1186/s12885-023-11518-6. PMID: 37932662Free PMC Article
Prophylactic HPV vaccination after conization: A systematic review and meta-analysis.
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older.
Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, Arbyn M, Bosch FX, Cuzick J, Dillner J, Heideman DA, Snijders PJ
Int J Cancer 2009 Feb 1;124(3):516-20. doi: 10.1002/ijc.24010. PMID: 18973271Free PMC Article

Diagnosis

Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States.
Bukowski A, Hoyo C, Vielot NA, Graff M, Kosorok MR, Brewster WR, Maguire RL, Murphy SK, Nedjai B, Ladoukakis E, North KE, Smith JS
BMC Cancer 2023 Nov 6;23(1):1072. doi: 10.1186/s12885-023-11518-6. PMID: 37932662Free PMC Article
HPV and DNA Methylation Testing in Urine for Cervical Intraepithelial Neoplasia and Cervical Cancer Detection.
van den Helder R, Steenbergen RDM, van Splunter AP, Mom CH, Tjiong MY, Martin I, Rosier-van Dunné FMF, van der Avoort IAM, Bleeker MCG, van Trommel NE
Clin Cancer Res 2022 May 13;28(10):2061-2068. doi: 10.1158/1078-0432.CCR-21-3710. PMID: 35266975
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older.
Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, Arbyn M, Bosch FX, Cuzick J, Dillner J, Heideman DA, Snijders PJ
Int J Cancer 2009 Feb 1;124(3):516-20. doi: 10.1002/ijc.24010. PMID: 18973271Free PMC Article

Therapy

Topical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasia (TOPIC-3): A Nonrandomized Multicenter Study.
Hendriks N, Koeneman MM, van de Sande AJM, Penders CGJ, Piek JMJ, Kooreman LFS, van Kuijk SMJ, Hoosemans L, Sep SJS, de Vos Van Steenwijk PJ, van Beekhuizen HJ, Slangen BFM, Nijman HW, Kruitwagen RFPM, Kruse AJ
J Immunother 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414. PMID: 35180719Free PMC Article
Prophylactic HPV vaccination after conization: A systematic review and meta-analysis.
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions.
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Characteristics of vaginal microbiota in various cervical intraepithelial neoplasia: a cross-sectional study.
Liu Y, Wang S, Liu J, Su M, Diao X, Liang X, Zhang J, Wang Q, Zhan Y
J Transl Med 2023 Nov 16;21(1):816. doi: 10.1186/s12967-023-04676-5. PMID: 37974192Free PMC Article
Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States.
Bukowski A, Hoyo C, Vielot NA, Graff M, Kosorok MR, Brewster WR, Maguire RL, Murphy SK, Nedjai B, Ladoukakis E, North KE, Smith JS
BMC Cancer 2023 Nov 6;23(1):1072. doi: 10.1186/s12885-023-11518-6. PMID: 37932662Free PMC Article
Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions.
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Clinical prediction guides

Long-term prediction by DNA methylation of high-grade cervical intraepithelial neoplasia: Results of the ARTISTIC cohort.
Gilham C, Nedjai B, Scibior-Bentkowska D, Reuter C, Banwait R, Brentnall AR, Cuzick J, Peto J, Lorincz AT
Int J Cancer 2024 Jul 1;155(1):81-92. Epub 2024 Mar 20 doi: 10.1002/ijc.34913. PMID: 38507581
Characteristics of vaginal microbiota in various cervical intraepithelial neoplasia: a cross-sectional study.
Liu Y, Wang S, Liu J, Su M, Diao X, Liang X, Zhang J, Wang Q, Zhan Y
J Transl Med 2023 Nov 16;21(1):816. doi: 10.1186/s12967-023-04676-5. PMID: 37974192Free PMC Article
Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States.
Bukowski A, Hoyo C, Vielot NA, Graff M, Kosorok MR, Brewster WR, Maguire RL, Murphy SK, Nedjai B, Ladoukakis E, North KE, Smith JS
BMC Cancer 2023 Nov 6;23(1):1072. doi: 10.1186/s12885-023-11518-6. PMID: 37932662Free PMC Article
MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy.
Causin RL, da Silva LS, Evangelista AF, Leal LF, Souza KCB, Pessôa-Pereira D, Matsushita GM, Reis RM, Fregnani JHTG, Marques MMC
Biomed Res Int 2021;2021:6650966. Epub 2021 Apr 13 doi: 10.1155/2021/6650966. PMID: 33954190Free PMC Article
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708

Recent systematic reviews

Treatment characteristics, HPV genotype distribution and risk of subsequent disease among women with high-grade cervical intraepithelial neoplasia in Europe: A systematic literature review.
Reuschenbach M, Valente S, Takyar J, Dhawan A, Hall A, Agrawal N, Ghelardi A, Del Pino M, Nowakowski A, Sabale U
Eur J Obstet Gynecol Reprod Biol 2024 Sep;300:129-140. Epub 2024 Jul 1 doi: 10.1016/j.ejogrb.2024.06.030. PMID: 39002399
Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis.
Papoutsis D, Underwood M, Parry-Smith W, Tzavara C
Arch Gynecol Obstet 2024 Mar;309(3):939-948. Epub 2023 Oct 11 doi: 10.1007/s00404-023-07242-y. PMID: 37821642Free PMC Article
The efficacy of topical imiquimod in high-grade cervical intraepithelial neoplasia: A systematic review and meta-analysis.
van de Sande AJM, Kengsakul M, Koeneman MM, Jozwiak M, Gerestein CG, Kruse AJ, van Esch EMG, de Vos van Steenwijk PJ, Muntinga CLP, Bramer WM, van Doorn HC, van Kemenade FJ, van Beekhuizen HJ
Int J Gynaecol Obstet 2024 Jan;164(1):66-74. Epub 2023 Jun 23 doi: 10.1002/ijgo.14953. PMID: 37350560
Prophylactic HPV vaccination after conization: A systematic review and meta-analysis.
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis.
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708

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