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Ciliary Body Spindle Cell Type B Melanoma

MedGen UID:
232078
•Concept ID:
C1333054
•
Neoplastic Process
Synonyms: Spindle Cell Type B Melanoma of Ciliary Body; Spindle Cell Type B Melanoma of the Ciliary Body

Definition

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary Body Spindle Cell Type B Melanoma

Recent clinical studies

Etiology

Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma?
Väisänen A, Kallioinen M, von Dickhoff K, Laatikainen L, Höyhtyä M, Turpeenniemi-Hujanen T
J Pathol 1999 May;188(1):56-62. doi: 10.1002/(SICI)1096-9896(199905)188:1<56::AID-PATH304>3.0.CO;2-B. PMID: 10398141
Bilateral ciliary body melanomas.
Waterhouse WJ, Fries PD, Char DH, Crawford JB, Howes EL Jr
Can J Ophthalmol 1989 Apr;24(3):125-8. PMID: 2659154
Are most iris "melanomas' really nevi? A clinicopathologic study of 189 lesions.
Jakobiec FA, Silbert G
Arch Ophthalmol 1981 Dec;99(12):2117-32. doi: 10.1001/archopht.1981.03930020993002. PMID: 7305709
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Diagnosis

Locally advanced choroidal melanoma with favorable molecular prognosis - case report.
Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Complete ring melanoma of the choroid.
Fitzpatrick M, Augsburger JJ, Koreishi FM, Eagle RC Jr
Retina 1996;16(3):228-31. doi: 10.1097/00006982-199616030-00008. PMID: 8789862
Are most iris "melanomas' really nevi? A clinicopathologic study of 189 lesions.
Jakobiec FA, Silbert G
Arch Ophthalmol 1981 Dec;99(12):2117-32. doi: 10.1001/archopht.1981.03930020993002. PMID: 7305709

Prognosis

Locally advanced choroidal melanoma with favorable molecular prognosis - case report.
Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma?
Väisänen A, Kallioinen M, von Dickhoff K, Laatikainen L, Höyhtyä M, Turpeenniemi-Hujanen T
J Pathol 1999 May;188(1):56-62. doi: 10.1002/(SICI)1096-9896(199905)188:1<56::AID-PATH304>3.0.CO;2-B. PMID: 10398141
Iridocyclectomy for melanomas of the ciliary body: a follow-up study of pathology and surgical morbidity.
Forrest AW, Keyser RB, Spencer WH
Ophthalmology 1978 Dec;85(12):1237-49. doi: 10.1016/s0161-6420(78)35560-3. PMID: 745829
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Clinical prediction guides

Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma?
Väisänen A, Kallioinen M, von Dickhoff K, Laatikainen L, Höyhtyä M, Turpeenniemi-Hujanen T
J Pathol 1999 May;188(1):56-62. doi: 10.1002/(SICI)1096-9896(199905)188:1<56::AID-PATH304>3.0.CO;2-B. PMID: 10398141
Iridocyclectomy for melanomas of the ciliary body: a follow-up study of pathology and surgical morbidity.
Forrest AW, Keyser RB, Spencer WH
Ophthalmology 1978 Dec;85(12):1237-49. doi: 10.1016/s0161-6420(78)35560-3. PMID: 745829
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

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