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Skin infectious agent

MedGen UID:
1841994
•Concept ID:
C5826550
•
Finding
HPO: HP:0034640

Definition

The presence of an infectious agent in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin infectious agent

Professional guidelines

PubMed

Cellulitis: A Review of Pathogenesis, Diagnosis, and Management.
Rrapi R, Chand S, Kroshinsky D
Med Clin North Am 2021 Jul;105(4):723-735. doi: 10.1016/j.mcna.2021.04.009. PMID: 34059247
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children.
Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF; Infectious Diseases Society of America
Clin Infect Dis 2011 Feb 1;52(3):e18-55. Epub 2011 Jan 4 doi: 10.1093/cid/ciq146. PMID: 21208910

Recent clinical studies

Etiology

Paracoccidioidomycosis: Current Status and Future Trends.
Hahn RC, Hagen F, Mendes RP, Burger E, Nery AF, Siqueira NP, Guevara A, Rodrigues AM, de Camargo ZP
Clin Microbiol Rev 2022 Dec 21;35(4):e0023321. Epub 2022 Sep 8 doi: 10.1128/cmr.00233-21. PMID: 36074014Free PMC Article
Cellulitis: A Review of Pathogenesis, Diagnosis, and Management.
Rrapi R, Chand S, Kroshinsky D
Med Clin North Am 2021 Jul;105(4):723-735. doi: 10.1016/j.mcna.2021.04.009. PMID: 34059247
How do I manage nocardiosis?
Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019
The treatment of resistant staphylococcal infections.
John J Jr
F1000Res 2020;9 Epub 2020 Feb 26 doi: 10.12688/f1000research.17718.1. PMID: 32148777Free PMC Article
Necrotizing skin and soft-tissue infections in the intensive care unit.
Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ
Clin Microbiol Infect 2020 Jan;26(1):8-17. Epub 2019 Jul 5 doi: 10.1016/j.cmi.2019.06.031. PMID: 31284035

Diagnosis

Paracoccidioidomycosis: Current Status and Future Trends.
Hahn RC, Hagen F, Mendes RP, Burger E, Nery AF, Siqueira NP, Guevara A, Rodrigues AM, de Camargo ZP
Clin Microbiol Rev 2022 Dec 21;35(4):e0023321. Epub 2022 Sep 8 doi: 10.1128/cmr.00233-21. PMID: 36074014Free PMC Article
New Practical Aspects of Sweet Syndrome.
Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247Free PMC Article
Cellulitis: A Review of Current Practice Guidelines and Differentiation from Pseudocellulitis.
Boettler MA, Kaffenberger BH, Chung CG
Am J Clin Dermatol 2022 Mar;23(2):153-165. Epub 2021 Dec 13 doi: 10.1007/s40257-021-00659-8. PMID: 34902109
How do I manage nocardiosis?
Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019
Skin and Soft Tissue Infections in Patients with Diabetes Mellitus.
Polk C, Sampson MM, Roshdy D, Davidson LE
Infect Dis Clin North Am 2021 Mar;35(1):183-197. Epub 2020 Dec 7 doi: 10.1016/j.idc.2020.10.007. PMID: 33303332

Therapy

Ozone therapy for skin diseases: Cellular and molecular mechanisms.
Liu L, Zeng L, Gao L, Zeng J, Lu J
Int Wound J 2023 Aug;20(6):2376-2385. Epub 2022 Dec 16 doi: 10.1111/iwj.14060. PMID: 36527235Free PMC Article
New Practical Aspects of Sweet Syndrome.
Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247Free PMC Article
Cellulitis: A Review of Current Practice Guidelines and Differentiation from Pseudocellulitis.
Boettler MA, Kaffenberger BH, Chung CG
Am J Clin Dermatol 2022 Mar;23(2):153-165. Epub 2021 Dec 13 doi: 10.1007/s40257-021-00659-8. PMID: 34902109
Potential of Curcumin in Skin Disorders.
Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E
Nutrients 2019 Sep 10;11(9) doi: 10.3390/nu11092169. PMID: 31509968Free PMC Article
Candida auris: an Emerging Fungal Pathogen.
Spivak ES, Hanson KE
J Clin Microbiol 2018 Feb;56(2) Epub 2018 Jan 24 doi: 10.1128/JCM.01588-17. PMID: 29167291Free PMC Article

Prognosis

Discovery of a structural class of antibiotics with explainable deep learning.
Wong F, Zheng EJ, Valeri JA, Donghia NM, Anahtar MN, Omori S, Li A, Cubillos-Ruiz A, Krishnan A, Jin W, Manson AL, Friedrichs J, Helbig R, Hajian B, Fiejtek DK, Wagner FF, Soutter HH, Earl AM, Stokes JM, Renner LD, Collins JJ
Nature 2024 Feb;626(7997):177-185. Epub 2023 Dec 20 doi: 10.1038/s41586-023-06887-8. PMID: 38123686Free PMC Article
Infections in Older Adults.
Scott MM, Liang SY
Emerg Med Clin North Am 2021 May;39(2):379-394. Epub 2021 Mar 23 doi: 10.1016/j.emc.2021.01.004. PMID: 33863466
Necrotizing skin and soft-tissue infections in the intensive care unit.
Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ
Clin Microbiol Infect 2020 Jan;26(1):8-17. Epub 2019 Jul 5 doi: 10.1016/j.cmi.2019.06.031. PMID: 31284035
Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, combined or not with use of a bundle of new devices, for prevention of short-term peripheral venous catheter-related infectious complications and catheter failure: an open-label, single-centre, randomised, four-parallel group, two-by-two factorial trial: CLEAN 3 protocol study.
Guenezan J, Drugeon B, O'Neill R, Caillaud D, Sénamaud C, Pouzet C, Seguin S, Frasca D, Mimoz O
BMJ Open 2019 Apr 2;9(4):e028549. doi: 10.1136/bmjopen-2018-028549. PMID: 30944142Free PMC Article
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.
Turner NA, Sharma-Kuinkel BK, Maskarinec SA, Eichenberger EM, Shah PP, Carugati M, Holland TL, Fowler VG Jr
Nat Rev Microbiol 2019 Apr;17(4):203-218. doi: 10.1038/s41579-018-0147-4. PMID: 30737488Free PMC Article

Clinical prediction guides

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.
Copaescu AM, Vogrin S, James F, Chua KYL, Rose MT, De Luca J, Waldron J, Awad A, Godsell J, Mitri E, Lambros B, Douglas A, Youcef Khoudja R, Isabwe GAC, Genest G, Fein M, Radojicic C, Collier A, Lugar P, Stone C, Ben-Shoshan M, Turner NA, Holmes NE, Phillips EJ, Trubiano JA
JAMA Intern Med 2023 Sep 1;183(9):944-952. doi: 10.1001/jamainternmed.2023.2986. PMID: 37459086Free PMC Article
New Practical Aspects of Sweet Syndrome.
Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247Free PMC Article
Cellulitis: A Review of Pathogenesis, Diagnosis, and Management.
Rrapi R, Chand S, Kroshinsky D
Med Clin North Am 2021 Jul;105(4):723-735. doi: 10.1016/j.mcna.2021.04.009. PMID: 34059247
Potential of Curcumin in Skin Disorders.
Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E
Nutrients 2019 Sep 10;11(9) doi: 10.3390/nu11092169. PMID: 31509968Free PMC Article
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987

Recent systematic reviews

Systematic literature review informing the 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases.
Fragoulis GE, Dey M, Zhao S, Schoones J, Courvoisier D, Galloway J, Hyrich KL, Nikiphorou E
RMD Open 2022 Nov;8(2) doi: 10.1136/rmdopen-2022-002726. PMID: 36323488Free PMC Article
How do I manage nocardiosis?
Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019
Ivermectin and permethrin for treating scabies.
Rosumeck S, Nast A, Dressler C
Cochrane Database Syst Rev 2018 Apr 2;4(4):CD012994. doi: 10.1002/14651858.CD012994. PMID: 29608022Free PMC Article
Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis.
Sinha Ray A, Haikal A, Hammoud KA, Yu ASL
Clin J Am Soc Nephrol 2016 Dec 7;11(12):2132-2140. Epub 2016 Nov 28 doi: 10.2215/CJN.05920616. PMID: 27895134Free PMC Article
Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis.
Nemeth J, Oesch G, Kuster SP
J Antimicrob Chemother 2015 Feb;70(2):382-95. Epub 2014 Sep 28 doi: 10.1093/jac/dku379. PMID: 25266070

Supplemental Content

Table of contents

    Clinical resources

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