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Neoplasm of ovary

MedGen UID:
181539
Concept ID:
C0919267
Neoplastic Process
Synonyms: Ovarian cancer; Ovarian Cancer; OVARIAN CANCER, SOMATIC; Ovarian tumor
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Ovarian tumor (123843001); Tumor of ovary (123843001); Neoplasm of ovary (123843001)
 
Genes: PIK3CA; PARK2; OPCML; CTNNB1; CDH1; AKT1
Cytogenetic locations: 11q25; 14q32.33; 16q22.1; 3p22.1; 3q26.32; 6q26
OMIM®: 167000

Definition

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008). [from OMIM]

Clinical features

Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a carcinoma of the breast.
Ovarian papillary adenocarcinoma
MedGen UID:
428658
Concept ID:
CN005897
Finding
The presence of a papillary adenocarcinoma of the ovary.
Dysgerminoma
MedGen UID:
506500
Concept ID:
CN117513
Finding
The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.
Ovarian papillary adenocarcinoma
MedGen UID:
428658
Concept ID:
CN005897
Finding
The presence of a papillary adenocarcinoma of the ovary.
Dysgerminoma
MedGen UID:
506500
Concept ID:
CN117513
Finding
The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.
Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a carcinoma of the breast.
Abnormality of metabolism/homeostasis
MedGen UID:
446429
Concept ID:
CN001754
Finding

Term Hierarchy

Professional guidelines

PubMed

Berliner JL, Fay AM, Cummings SA, Burnett B, Tillmanns T
J Genet Couns 2013 Apr;22(2):155-63. Epub 2012 Nov 28 doi: 10.1007/s10897-012-9547-1. [Epub ahead of print] PMID: 23188549
Moyer VA; U.S. Preventive Services Task Force
Ann Intern Med 2012 Dec 18;157(12):900-4. doi: 10.7326/0003-4819-157-11-201212040-00539. PMID: 22964825
Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brünner N, Chan DW, Babaian R, Bast RC Jr, Dowell B, Esteva FJ, Haglund C, Harbeck N, Hayes DF, Holten-Andersen M, Klee GG, Lamerz R, Looijenga LH, Molina R, Nielsen HJ, Rittenhouse H, Semjonow A, Shih IeM, Sibley P, Sölétormos G, Stephan C, Sokoll L, Hoffman BR, Diamandis EP; National Academy of Clinical Biochemistry
Clin Chem 2008 Dec;54(12):e11-79. doi: 10.1373/clinchem.2008.105601. PMID: 19042984

Recent clinical studies

Etiology

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Diagnosis

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Therapy

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Clinical prediction guides

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

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