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Fredrickson Type III Lipidemia

MedGen UID:
167816
•Concept ID:
C0860248
•
Disease or Syndrome

Definition

A laboratory test result indicating an inheritable form of dysbetalipoproteinemia, in which there are excess intermediate-density lipoproteins in the blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFredrickson Type III Lipidemia

Professional guidelines

PubMed

Rosuvastatin for the treatment of hypercholesterolemia.
Culhane NS, Lettieri SL, Skae JR
Pharmacotherapy 2005 Jul;25(7):990-1000. doi: 10.1592/phco.2005.25.7.990. PMID: 16006277

Recent clinical studies

Etiology

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators
N Engl J Med 2022 Nov 24;387(21):1923-1934. Epub 2022 Nov 5 doi: 10.1056/NEJMoa2210645. PMID: 36342113
Dysbetalipoproteinemia: Differentiating Multifactorial Remnant Cholesterol Disease From Genetic ApoE Deficiency.
Paquette M, Bernard S, Paré G, Baass A
J Clin Endocrinol Metab 2022 Jan 18;107(2):538-548. doi: 10.1210/clinem/dgab648. PMID: 34467996
Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.
Marais AD, Solomon GA, Blom DJ
Crit Rev Clin Lab Sci 2014 Feb;51(1):46-62. Epub 2014 Jan 9 doi: 10.3109/10408363.2013.870526. PMID: 24405372
High frequency of Fredrickson's phenotypes IV and IIb in Brazilians infected by human immunodeficiency virus.
Albuquerque EM, de Faria EC, Oliveira HC, Magro DO, Castilho LN
BMC Infect Dis 2005 Jun 14;5:47. doi: 10.1186/1471-2334-5-47. PMID: 15955243Free PMC Article
Type III hyperlipoproteinemia: an analysis of two contemporary definitions.
Fredrickson DS, Morganroth J, Levy RI
Ann Intern Med 1975 Feb;82(2):150-7. doi: 10.7326/0003-4819-82-2-150. PMID: 163607

Diagnosis

Diagnosis of remnant hyperlipidaemia.
Paquette M, Bernard S, Baass A
Curr Opin Lipidol 2022 Aug 1;33(4):227-230. doi: 10.1097/MOL.0000000000000831. PMID: 35942808
Dysbetalipoproteinemia: an extreme disorder of remnant metabolism.
Marais D
Curr Opin Lipidol 2015 Aug;26(4):292-7. doi: 10.1097/MOL.0000000000000192. PMID: 26103610
Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.
Marais AD, Solomon GA, Blom DJ
Crit Rev Clin Lab Sci 2014 Feb;51(1):46-62. Epub 2014 Jan 9 doi: 10.3109/10408363.2013.870526. PMID: 24405372
Two-dimensional immunoelectrophrophoretic pattern of low- and very-low-density lipoproteins, with particular reference to Fredrickson's type III.
Rerabek JE
Clin Chem 1977 Feb;23(2 PT. 1):186-94. PMID: 188564
The biochemical, clinical, and genetic features of type III hyperlipoproteinemia.
Morganroth J, Levy RI, Fredrickson DS
Ann Intern Med 1975 Feb;82(2):158-74. doi: 10.7326/0003-4819-82-2-158. PMID: 163608

Therapy

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators
N Engl J Med 2022 Nov 24;387(21):1923-1934. Epub 2022 Nov 5 doi: 10.1056/NEJMoa2210645. PMID: 36342113
Rosuvastatin for the treatment of hypercholesterolemia.
Culhane NS, Lettieri SL, Skae JR
Pharmacotherapy 2005 Jul;25(7):990-1000. doi: 10.1592/phco.2005.25.7.990. PMID: 16006277
High frequency of Fredrickson's phenotypes IV and IIb in Brazilians infected by human immunodeficiency virus.
Albuquerque EM, de Faria EC, Oliveira HC, Magro DO, Castilho LN
BMC Infect Dis 2005 Jun 14;5:47. doi: 10.1186/1471-2334-5-47. PMID: 15955243Free PMC Article
Update on fenofibrate.
Guay DR
Cardiovasc Drug Rev 2002 Winter;20(4):281-302. doi: 10.1111/j.1527-3466.2002.tb00098.x. PMID: 12481201
Patterns of dyslipoproteinemia in selected North American populations. The Lipid Research Clinics Program Prevalence Study.
LaRosa JC, Chambless LE, Criqui MH, Frantz ID, Glueck CJ, Heiss G, Morrison JA
Circulation 1986 Jan;73(1 Pt 2):I12-29. PMID: 3940679

Prognosis

Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.
Marais AD, Solomon GA, Blom DJ
Crit Rev Clin Lab Sci 2014 Feb;51(1):46-62. Epub 2014 Jan 9 doi: 10.3109/10408363.2013.870526. PMID: 24405372
Studies on the phenotyping system of hyperlipoproteinemias. Evaluation of a new method by enzymic staining of lipids in serum lipoproteins separated by electrophoresis on agarose.
Ohno F, Suehiro T, Uga S, Kawada M, Takamatsu K, Yasuoka N, Yamano T
Jpn J Med 1983 Aug;22(3):200-5. doi: 10.2169/internalmedicine1962.22.200. PMID: 6620708

Clinical prediction guides

Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.
Marais AD, Solomon GA, Blom DJ
Crit Rev Clin Lab Sci 2014 Feb;51(1):46-62. Epub 2014 Jan 9 doi: 10.3109/10408363.2013.870526. PMID: 24405372
Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia.
Hunninghake DB, Stein EA, Bays HE, Rader DJ, Chitra RR, Simonson SG, Schneck DW
Coron Artery Dis 2004 Mar;15(2):115-23. doi: 10.1097/00019501-200403000-00008. PMID: 15024300
Studies on the phenotyping system of hyperlipoproteinemias. Evaluation of a new method by enzymic staining of lipids in serum lipoproteins separated by electrophoresis on agarose.
Ohno F, Suehiro T, Uga S, Kawada M, Takamatsu K, Yasuoka N, Yamano T
Jpn J Med 1983 Aug;22(3):200-5. doi: 10.2169/internalmedicine1962.22.200. PMID: 6620708

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