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Metastatic Unresectable Basal Cell Carcinoma

MedGen UID:
1670057
•Concept ID:
C4745066
•
Neoplastic Process

Definition

A basal cell carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Unresectable Basal Cell Carcinoma

Professional guidelines

PubMed

Identifying locally advanced basal cell carcinoma eligible for treatment with vismodegib: an expert panel consensus.
Peris K, Licitra L, Ascierto PA, Corvò R, Simonacci M, Picciotto F, Gualdi G, Pellacani G, Santoro A
Future Oncol 2015;11(4):703-12. doi: 10.2217/fon.14.281. PMID: 25686123
Optimal treatment of unresectable nonmelanoma skin cancers.
Olencki T
J Natl Compr Canc Netw 2014 May;12(5 Suppl):789-92. doi: 10.6004/jnccn.2014.0191. PMID: 24853218
Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.
Cirrone F, Harris CS
Clin Ther 2012 Oct;34(10):2039-50. Epub 2012 Oct 1 doi: 10.1016/j.clinthera.2012.08.011. PMID: 23036338

Recent clinical studies

Etiology

Matrix metalloproteinases in keratinocyte carcinomas.
Riihilä P, Nissinen L, Kähäri VM
Exp Dermatol 2021 Jan;30(1):50-61. Epub 2020 Sep 17 doi: 10.1111/exd.14183. PMID: 32869366Free PMC Article
The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.
Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma.
Chang AL, Lewis KD, Arron ST, Migden MR, Solomon JA, Yoo S, Day BM, McKenna EF, Sekulic A
Oncotarget 2016 Nov 15;7(46):76118-76124. doi: 10.18632/oncotarget.12660. PMID: 27764798Free PMC Article
A comprehensive review of the role of the hedgehog pathway and vismodegib in the management of basal cell carcinoma.
Erdem GU, Sendur MA, Ozdemir NY, Yazıcı O, Zengin N
Curr Med Res Opin 2015 Apr;31(4):743-56. Epub 2015 Mar 17 doi: 10.1185/03007995.2015.1018988. PMID: 25690490
Identifying locally advanced basal cell carcinoma eligible for treatment with vismodegib: an expert panel consensus.
Peris K, Licitra L, Ascierto PA, Corvò R, Simonacci M, Picciotto F, Gualdi G, Pellacani G, Santoro A
Future Oncol 2015;11(4):703-12. doi: 10.2217/fon.14.281. PMID: 25686123

Diagnosis

Japanese Dermatological Association guidelines: Outlines of Japanese clinical guidelines for basal cell carcinoma 2021.
Hoashi T, Ishikawa M, Uehara J, Oashi K, Maeda S, Kato J, Saruta H, Shichinohe R, Ohashi R, Nakamura Y, Koga H, Sugaya M; Basal Cell Carcinoma Guidelines Committee of the Japanese Skin Cancer Society
J Dermatol 2024 Apr;51(4):e90-e105. Epub 2024 Jan 24 doi: 10.1111/1346-8138.16944. PMID: 38264942
Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
Gray HJ, Bell-McGuinn K, Fleming GF, Cristea M, Xiong H, Sullivan D, Luo Y, McKee MD, Munasinghe W, Martin LP
Gynecol Oncol 2018 Mar;148(3):507-514. Epub 2018 Jan 17 doi: 10.1016/j.ygyno.2017.12.029. PMID: 29352572
Vismodegib induces significant clinical response in locally advanced trichoblastic carcinoma.
Lepesant P, Crinquette M, Alkeraye S, Mirabel X, Dziwniel V, Cribier B, Mortier L
Br J Dermatol 2015 Oct;173(4):1059-62. Epub 2015 Aug 27 doi: 10.1111/bjd.13919. PMID: 25998864
Identifying locally advanced basal cell carcinoma eligible for treatment with vismodegib: an expert panel consensus.
Peris K, Licitra L, Ascierto PA, Corvò R, Simonacci M, Picciotto F, Gualdi G, Pellacani G, Santoro A
Future Oncol 2015;11(4):703-12. doi: 10.2217/fon.14.281. PMID: 25686123
The clinical course of lung carcinoma in patients with chronic lymphocytic leukemia.
Parekh K, Rusch V, Kris M
Cancer 1999 Nov 1;86(9):1720-3. PMID: 10547544

Therapy

The Landmark Series: Non-melanoma Skin Cancers.
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317
Emerging Nonsurgical Therapies for Locally Advanced and Metastatic Nonmelanoma Skin Cancer.
Chen L, Aria AB, Silapunt S, Migden MR
Dermatol Surg 2019 Jan;45(1):1-16. doi: 10.1097/DSS.0000000000001601. PMID: 30045105
Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article
Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.
Cirrone F, Harris CS
Clin Ther 2012 Oct;34(10):2039-50. Epub 2012 Oct 1 doi: 10.1016/j.clinthera.2012.08.011. PMID: 23036338
Vismodegib in basal cell carcinoma.
Amaria RN, Bowles DW, Lewis KD, Jimeno A
Drugs Today (Barc) 2012 Jul;48(7):459-67. doi: 10.1358/dot.2012.48.7.1808490. PMID: 22844657

Prognosis

The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.
Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article
The clinical course of lung carcinoma in patients with chronic lymphocytic leukemia.
Parekh K, Rusch V, Kris M
Cancer 1999 Nov 1;86(9):1720-3. PMID: 10547544
Metastatic basal cell carcinoma.
Grace GT, Elias EG
Md Med J 1991 Sep;40(9):799-801. PMID: 1921657

Clinical prediction guides

The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.
Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article
Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade.
Lipson EJ, Lilo MT, Ogurtsova A, Esandrio J, Xu H, Brothers P, Schollenberger M, Sharfman WH, Taube JM
J Immunother Cancer 2017;5:23. Epub 2017 Mar 21 doi: 10.1186/s40425-017-0228-3. PMID: 28344809Free PMC Article
Weekly Multi-agent Chemotherapy (CMF-b) for Advanced Non-melanoma Skin Cancer.
Espeli V, Ruegg E, Hottinger AF, Modarressi A, Dietrich PY
Anticancer Res 2016 May;36(5):2359-64. PMID: 27127144
Treatment of unresectable squamous cell carcinoma of the skin with epidermal growth factor receptor antibodies--a case series.
Eder J, Simonitsch-Klupp I, Trautinger F
Eur J Dermatol 2013 Sep-Oct;23(5):658-62. doi: 10.1684/ejd.2013.2153. PMID: 24135559

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