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Stage I Ovarian Choriocarcinoma

MedGen UID:
163165
•Concept ID:
C0854941
•
Neoplastic Process
Synonyms: Stage I Ovarian Choriocarcinoma AJCC v6; Stage I Ovarian Choriocarcinoma AJCC v7; Stage I Ovarian Germ Cell Choriocarcinoma

Definition

Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage I Ovarian Choriocarcinoma

Professional guidelines

PubMed

FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology.
Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S
Int J Gynaecol Obstet 2000 Aug;70(2):209-62. PMID: 11041682
Evaluation and management of pediatric solid ovarian tumors.
Lazar EL, Stolar CJ
Semin Pediatr Surg 1998 Feb;7(1):29-34. doi: 10.1016/s1055-8586(98)70003-4. PMID: 9498265
Childhood ovarian cancers. New advances in treatment.
Piver MS, Lurain J
N Y State J Med 1979 Jul;79(8):1196-9. PMID: 223094

Recent clinical studies

Etiology

Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.
Rich BS, Dicken BJ, Billmire DF, Weil BR, Ross J, Fallahazad N, Krailo M, Shaikh F, Frazier AL, Hazard FK, Nuño MM
J Pediatr Surg 2023 Dec;58(12):2399-2404. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.008. PMID: 37699777Free PMC Article
Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group.
Dicken BJ, Billmire DF, Rich B, Hazard FK, Nuño M, Krailo M, Fallahazad N, Pashankar F, Shaikh F, Frazier AL
Gynecol Oncol 2022 Sep;166(3):476-480. Epub 2022 Jun 22 doi: 10.1016/j.ygyno.2022.06.013. PMID: 35750503Free PMC Article
Ovarian Tumors: Pattern of Histomorphological Types- A 10 Years Study in a Tertiary Referral Center and Review of Literature.
Ghosh A, Ghartimagar D, Thapa S, Sathian B, Narasimhan R, Talwar OP
Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):153-158. PMID: 28166073
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976

Diagnosis

Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group.
Dicken BJ, Billmire DF, Rich B, Hazard FK, Nuño M, Krailo M, Fallahazad N, Pashankar F, Shaikh F, Frazier AL
Gynecol Oncol 2022 Sep;166(3):476-480. Epub 2022 Jun 22 doi: 10.1016/j.ygyno.2022.06.013. PMID: 35750503Free PMC Article
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976
Pure nongestational choriocarcinoma of ovary.
Corakçi A, Ozeren S, Ozkan S, Gürbüz Y, Ustün H, Yücesoy I
Arch Gynecol Obstet 2005 Feb;271(2):176-7. Epub 2004 Feb 28 doi: 10.1007/s00404-004-0604-3. PMID: 14991382
Evaluation and management of pediatric solid ovarian tumors.
Lazar EL, Stolar CJ
Semin Pediatr Surg 1998 Feb;7(1):29-34. doi: 10.1016/s1055-8586(98)70003-4. PMID: 9498265

Therapy

The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961
Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group.
Billmire DF, Cullen JW, Rescorla FJ, Davis M, Schlatter MG, Olson TA, Malogolowkin MH, Pashankar F, Villaluna D, Krailo M, Egler RA, Rodriguez-Galindo C, Frazier AL
J Clin Oncol 2014 Feb 10;32(5):465-70. Epub 2014 Jan 6 doi: 10.1200/JCO.2013.51.1006. PMID: 24395845Free PMC Article
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976
Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature.
Pentheroudakis G, White J, Davis J, Brown I, Vasey P
Gynecol Oncol 2004 Feb;92(2):697-700. doi: 10.1016/j.ygyno.2003.10.049. PMID: 14766269
Cerebral metastases from ovarian carcinoma.
LeRoux PD, Berger MS, Elliott JP, Tamimi HK
Cancer 1991 Apr 15;67(8):2194-9. doi: 10.1002/1097-0142(19910415)67:8<2194::aid-cncr2820670832>3.0.co;2-#. PMID: 2004340

Prognosis

Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.
Rich BS, Dicken BJ, Billmire DF, Weil BR, Ross J, Fallahazad N, Krailo M, Shaikh F, Frazier AL, Hazard FK, Nuño MM
J Pediatr Surg 2023 Dec;58(12):2399-2404. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.008. PMID: 37699777Free PMC Article
Ovarian Tumors: Pattern of Histomorphological Types- A 10 Years Study in a Tertiary Referral Center and Review of Literature.
Ghosh A, Ghartimagar D, Thapa S, Sathian B, Narasimhan R, Talwar OP
Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):153-158. PMID: 28166073
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976
Choriocarcinoma of the ovary.
Axe SR, Klein VR, Woodruff JD
Obstet Gynecol 1985 Jul;66(1):111-4. PMID: 4040229

Clinical prediction guides

Need for risk-adapted therapy for malignant ovarian germ cell tumors: A large multicenter analysis of germ cell tumors' patients from French TMRG network.
Derquin F, Floquet A, Hardy-Bessard AC, Edeline J, Lotz JP, Alexandre J, Pautier P, Angeles MA, Delanoy N, Lefeuvre-Plesse C, Cancel M, Treilleux I, Augereau P, Lavoue V, Kalbacher E, Berton Rigaud D, Selle F, Nadeau C, Gantzer J, Joly F, Guillemet C, Pomel C, Favier L, Abdeddaim C, Venat-Bouvet L, Provansal M, Fabbro M, Kaminsky MC, Lortholary A, Lecuru F, Coquard IR, de La Motte Rouge T
Gynecol Oncol 2020 Sep;158(3):666-672. Epub 2020 Jul 3 doi: 10.1016/j.ygyno.2020.06.491. PMID: 32624235
Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group.
Billmire DF, Cullen JW, Rescorla FJ, Davis M, Schlatter MG, Olson TA, Malogolowkin MH, Pashankar F, Villaluna D, Krailo M, Egler RA, Rodriguez-Galindo C, Frazier AL
J Clin Oncol 2014 Feb 10;32(5):465-70. Epub 2014 Jan 6 doi: 10.1200/JCO.2013.51.1006. PMID: 24395845Free PMC Article
Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases.
Kurman RJ, Norris HJ
Obstet Gynecol 1976 Nov;48(5):579-89. PMID: 185553

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