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Malignant Pancreatic Neoplasm

MedGen UID:
138068
Concept ID:
C0346647
Neoplastic Process
Synonyms: Cancer of Pancreas; Cancer of the Pancreas; Cancer, Pancreas; Cancer, Pancreatic; Cancers, Pancreas; Cancers, Pancreatic; Pancreas Cancer; Pancreas Cancers; Pancreatic Cancer; Pancreatic Cancers
SNOMED CT: CA - Cancer of pancreas (363418001); Pancreatic cancer (363418001); CA - Pancreatic cancer (363418001); Malignant tumor of pancreas (363418001)
 

Definition

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include: - Smoking . - Long-term diabetes . - Chronic pancreatitis . - Certain hereditary disorders . Pancreatic cancer is hard to catch early. It doesn't cause symptoms right away. When you do get symptoms, they are often vague or you may not notice them. They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. Also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. Doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it. Because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. Possible treatments include surgery, radiation, chemotherapy, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. NIH: National Cancer Institute.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGMalignant Pancreatic Neoplasm

Recent clinical studies

Etiology

Ulla JL, Martinez MA, Paz-Esquete J, Garcia-Arroyo R, Dominguez-Comesaña E, Vazquez-Astray E
Am J Ther 2011 Mar-Apr;18(2):101-6. doi: 10.1097/MJT.0b013e3181c219be. PMID: 20019588
Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, Pawlik TM, Schulick RD, Choti MA
Ann Surg 2009 Aug;250(2):277-81. doi: 10.1097/SLA.0b013e3181ae34be. PMID: 19638926

Diagnosis

Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Conway AB, Cook SM, Samad A, Attam R, Pambuccian SE
Diagn Cytopathol 2013 Aug;41(8):661-72. Epub 2011 Nov 1 doi: 10.1002/dc.21832. [Epub ahead of print] PMID: 22045629
Ulla JL, Martinez MA, Paz-Esquete J, Garcia-Arroyo R, Dominguez-Comesaña E, Vazquez-Astray E
Am J Ther 2011 Mar-Apr;18(2):101-6. doi: 10.1097/MJT.0b013e3181c219be. PMID: 20019588
Vanbeckevoort D
JBR-BTR 2007 Nov-Dec;90(6):487-9. PMID: 18376761
Geenen JE
Can J Gastroenterol 2000 Feb;14(2):127-9. PMID: 10694285

Therapy

Ulla JL, Martinez MA, Paz-Esquete J, Garcia-Arroyo R, Dominguez-Comesaña E, Vazquez-Astray E
Am J Ther 2011 Mar-Apr;18(2):101-6. doi: 10.1097/MJT.0b013e3181c219be. PMID: 20019588
Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, Pawlik TM, Schulick RD, Choti MA
Ann Surg 2009 Aug;250(2):277-81. doi: 10.1097/SLA.0b013e3181ae34be. PMID: 19638926
Geenen JE
Can J Gastroenterol 2000 Feb;14(2):127-9. PMID: 10694285

Prognosis

Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, Pawlik TM, Schulick RD, Choti MA
Ann Surg 2009 Aug;250(2):277-81. doi: 10.1097/SLA.0b013e3181ae34be. PMID: 19638926
Vanbeckevoort D
JBR-BTR 2007 Nov-Dec;90(6):487-9. PMID: 18376761

Clinical prediction guides

Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article

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