Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Asymmetric Septal Hypertrophy(ASH)

MedGen UID:
104705
Concept ID:
C0205700
Disease or Syndrome
Synonyms: Asymmetric Septal Hypertrophies; Hypertrophies, Asymmetric Septal; Hypertrophy, Asymmetric Septal; Septal Hypertrophies, Asymmetric; Septal Hypertrophy, Asymmetric
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
 
OMIM: 192600

Definition

myocardial disease characterized by general increase in bulk of the myocardium due to an increase in cell volume; it is not due to tumor formation, nor to an increase in the number of cells; involving mainly the interventricular septum, interfering with left ventricular emptying. [from CRISP]

Clinical features

Congestive heart failure
MedGen UID:
504881
Concept ID:
CN001488
Finding
The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
Asymmetric septal hypertrophy
MedGen UID:
504902
Concept ID:
CN001519
Finding
Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray.
Subaortic stenosis
MedGen UID:
504908
Concept ID:
CN001531
Finding
A fixed form of obstruction to blood flow across the `left-ventricular outflow tract` (FMA:9473) related to stenosis (narrowing) below the level of the aortic valve.

Recent clinical studies

Etiology

Di Tommaso L, Stassano P, Mannacio V, Russolillo V, Monaco M, Pinna G, Vosa C
J Thorac Cardiovasc Surg 2013 Jan;145(1):171-5. Epub 2012 Feb 15 doi: 10.1016/j.jtcvs.2011.10.096. [Epub ahead of print] PMID: 22341422
Narsupalli S, Castle B, Veldtman G
Cardiol Young 2010 Oct;20(5):580-3. Epub 2010 Jul 21 doi: 10.1017/S1047951110000880. [Epub ahead of print] PMID: 20663266
Kuznetsov VA, Yaroslavskaya EI, Zyrianov IP, Kolunin GV, Krinochkin DV, Bessonova MI, Bessonov IS
Eur J Echocardiogr 2010 Sep;11(8):698-702. Epub 2010 Apr 10 doi: 10.1093/ejechocard/jeq046. [Epub ahead of print] PMID: 20382976
Litovsky SH, Rose AG
Arch Pathol Lab Med 1998 May;122(5):434-41. PMID: 9593345
van Dorp WG, ten Cate FJ, Vletter WB, Dohmen H, Roelandt J
Eur J Cardiol 1976 Sep;4(3):349-57. PMID: 964283

Diagnosis

Di Tommaso L, Stassano P, Mannacio V, Russolillo V, Monaco M, Pinna G, Vosa C
J Thorac Cardiovasc Surg 2013 Jan;145(1):171-5. Epub 2012 Feb 15 doi: 10.1016/j.jtcvs.2011.10.096. [Epub ahead of print] PMID: 22341422
Gaillard E, Kadem L, Pibarot P, Durand LG
J Heart Valve Dis 2012 Sep;21(5):623-7. PMID: 23167227
Shim CY, Yoon SB, Kim YJ, Ha JW, Chung N
J Am Coll Cardiol 2011 May 10;57(19):e213. doi: 10.1016/j.jacc.2010.08.653. PMID: 21545939
Narsupalli S, Castle B, Veldtman G
Cardiol Young 2010 Oct;20(5):580-3. Epub 2010 Jul 21 doi: 10.1017/S1047951110000880. [Epub ahead of print] PMID: 20663266
Kuznetsov VA, Yaroslavskaya EI, Zyrianov IP, Kolunin GV, Krinochkin DV, Bessonova MI, Bessonov IS
Eur J Echocardiogr 2010 Sep;11(8):698-702. Epub 2010 Apr 10 doi: 10.1093/ejechocard/jeq046. [Epub ahead of print] PMID: 20382976

Therapy

Di Tommaso L, Stassano P, Mannacio V, Russolillo V, Monaco M, Pinna G, Vosa C
J Thorac Cardiovasc Surg 2013 Jan;145(1):171-5. Epub 2012 Feb 15 doi: 10.1016/j.jtcvs.2011.10.096. [Epub ahead of print] PMID: 22341422
Kim MS, Klein AJ, Groves BM, Quaife RA, Salcedo EE
Eur J Echocardiogr 2008 Sep;9(5):720-4. Epub 2008 Apr 14 doi: 10.1093/ejechocard/jen152. [Epub ahead of print] PMID: 18490281
Wilansky S, Pollick C
Can J Cardiol 1989 Mar;5(2):75-6. PMID: 2706576
Jackson G, Anand IS, Oram S
Br Heart J 1979 Nov;42(5):611-4. PMID: 518788Free PMC Article
Abbasi AS, Slaughter JC, Allen MW
Chest 1978 Nov;74(5):548-51. PMID: 153829

Prognosis

Narsupalli S, Castle B, Veldtman G
Cardiol Young 2010 Oct;20(5):580-3. Epub 2010 Jul 21 doi: 10.1017/S1047951110000880. [Epub ahead of print] PMID: 20663266
Tuseth N, Cramariuc D, Rieck AE, Wachtell K, Gerdts E
Blood Press 2010 Jun;19(3):140-4. doi: 10.3109/08037051.2010.481816. PMID: 20429691
Sagesaka T, Liang SG, Morioka H, Watanabe T, Kaibara M, Dohba N
J Obstet Gynaecol Res 1997 Apr;23(2):147-51. PMID: 9158301
Hori T, Fujiwara H, Tanaka M, Matsuda M, Tsuyuguchi N, Suoh M
Jpn Circ J 1987 Feb;51(2):153-6. PMID: 2955139
Henning H, O'Rourke RA, Crawford MH, Righetti A, Karliner JS
Am J Cardiol 1978 May 1;41(5):817-22. PMID: 148208

Clinical prediction guides

Tuseth N, Cramariuc D, Rieck AE, Wachtell K, Gerdts E
Blood Press 2010 Jun;19(3):140-4. doi: 10.3109/08037051.2010.481816. PMID: 20429691
Kuznetsov VA, Yaroslavskaya EI, Zyrianov IP, Kolunin GV, Krinochkin DV, Bessonova MI, Bessonov IS
Eur J Echocardiogr 2010 Sep;11(8):698-702. Epub 2010 Apr 10 doi: 10.1093/ejechocard/jeq046. [Epub ahead of print] PMID: 20382976
Nunoda S, Genda A
Heart Vessels 1991;6(2):116-20. PMID: 2071548
Henning H, O'Rourke RA, Crawford MH, Righetti A, Karliner JS
Am J Cardiol 1978 May 1;41(5):817-22. PMID: 148208
Chandraratna PA, Tolentino AO, Mutucumarana W, Gomez AL
Circulation 1977 Apr;55(4):622-6. PMID: 837506

Recent systematic reviews

Thiebaugeorges O, Guyard-Boileau B
Diabetes Metab 2010 Dec;36(6 Pt 2):672-81. doi: 10.1016/j.diabet.2010.11.017. PMID: 21163429

Supplemental Content

Table of contents

    Medical Encyclopedia

    Outreach and support

    PubMed Health

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...