Heterogeneity of mismatch repair defect in colorectal cancer and its implications in clinical practice

Eur J Cancer. 2018 May:95:112-116. doi: 10.1016/j.ejca.2018.01.087. Epub 2018 Mar 5.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / therapy
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology*
  • Colorectal Neoplasms / therapy
  • DNA Mismatch Repair / genetics*
  • DNA-Binding Proteins / genetics
  • Genetic Heterogeneity*
  • Genetic Testing / methods
  • Humans
  • Male
  • Middle Aged
  • Mismatch Repair Endonuclease PMS2 / genetics
  • MutL Protein Homolog 1 / genetics
  • MutS Homolog 2 Protein / genetics
  • Practice Patterns, Physicians' / trends
  • Tissue Array Analysis

Substances

  • DNA-Binding Proteins
  • G-T mismatch-binding protein
  • MLH1 protein, human
  • PMS2 protein, human
  • MSH2 protein, human
  • Mismatch Repair Endonuclease PMS2
  • MutL Protein Homolog 1
  • MutS Homolog 2 Protein