Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance

Clin Infect Dis. 2018 Jun 18;67(1):137-140. doi: 10.1093/cid/ciy056.

Abstract

New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 concentration and worse neuropsychological performance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • HIV Core Protein p24 / cerebrospinal fluid*
  • HIV Infections / cerebrospinal fluid*
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV-1 / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / etiology*
  • Neuropsychological Tests
  • RNA, Viral / blood
  • RNA, Viral / cerebrospinal fluid

Substances

  • HIV Core Protein p24
  • RNA, Viral