Abstract
The penicillin-binding protein 2a (PBP2a) assay is a quick, accurate and inexpensive test for determining methicillin susceptibility in Staphylococcus aureus. A pre-post-study design was conducted using a PBP2a assay with and without the impact of an antimicrobial stewardship intervention to improve time to optimal therapy for methicillin-susceptible and methicillin-resistant S. aureus isolates. Our results demonstrate significantly improved time to optimal therapy and support the use of a PBP2a assay as part of an programme for all healthcare facilities, especially those with limited resources.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Female
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Humans
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Male
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Methicillin Resistance
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Methicillin-Resistant Staphylococcus aureus / chemistry
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Typing*
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Penicillin-Binding Proteins / analysis*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / chemistry*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
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Staphylococcus aureus / isolation & purification
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Time-to-Treatment*
Substances
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Anti-Bacterial Agents
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Penicillin-Binding Proteins