Click to search

Impact of a better persistence with antihypertensive agents on ischemic stroke outcomes for secondary prevention.

Authors

Xu J1, Zhao X, Wang Y, Wang C, Liu L, Sun B, Wang A, Wang Y.
Author information
  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Journal

PLoS One. 2013 Jun 11;8(6):e65233. doi: 10.1371/journal.pone.0065233. Print 2013.

Affiliation

Abstract

BACKGROUND: The efficacy of antihypertensive (AH) treatment after stroke has been investigated in several randomized clinical trials. However, non-adherence to AH medication is common for stroke patients in "real world" setting. The purpose of this study was to assess the impact of persistence with AH agents on ischemic stroke (IS) outcomes.

METHODS AND RESULTS: Using the China National Stroke Registry, we analyzed data from 8409 IS patients with hypertension. Persistence with AH therapy (high persistence ≥75%, low persistence <75%) was measured by patient self-report at 3, 6, and 12 months after stroke. Multivariate logistic regression model was used to assess the relationship between persistence and IS outcomes (stroke recurrence, combined vascular events and death) at 12 months. Of the 8409 patients in this study, 40.0% were female and the mean age at study entry was 66.7 years. 31.6% of patients had high persistence with AH drugs, and 68.4% had low persistence during 1 year after stroke onset. High persistence with AH drugs significantly decreased the risk of stroke recurrence (odds ratio, 0.78; 95% CI, 0.68 to 0.89), combined vascular events (0.71; 0.63-0.81) and death (0.44; 0.36-0.53) compared with low persistence.

CONCLUSIONS: Our study reinforces the benefits of AH medications in routine clinical practice and highlights the importance of persistence with AH therapy among IS patients known to be hypertensive within the first year of an event.

PMID

23776454 [PubMed - indexed for MEDLINE]

PMCID

PMC3679119 Free full text
Public Library of Science: Free full text
 Citation 2 of 87 Back to results 
Standard PubMed