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Extracolonic manifestations of lynch syndrome.

Authors

Bansidhar BJ1.
Author information
  • 1Department of Colon and Rectal Surgery, Saint Vincent Health Center, Erie, Pennsylvania.

Journal

Clin Colon Rectal Surg. 2012 Jun;25(2):103-10. doi: 10.1055/s-0032-1313781.

Affiliation

Abstract

Lynch syndrome has classically been defined by several predominant malignancies. Initial clinical criteria for diagnosis of Lynch syndrome would miss 40% of affected individuals. As time has passed, our understanding of Lynch syndrome has evolved and will continue to do so. The number of cancer types that are included in the Lynch phenotype is growing. This has allowed clinicians to redefine Lynch syndrome, at risk populations, screening needs, and diagnostic criteria. Inclusion of extracolonic malignancies and alternative genetic pathways gives new insight into the true prevalence and penetrance of Lynch syndrome.

PMID

23730225 [PubMed]

PMCID

PMC3423888 Free full text
Georg Thieme Verlag Stuttgart, New York: Free full text
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