Abstract
The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation.
Published by Elsevier B.V.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents*
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Antioxidants / pharmacology*
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Apomorphine
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Behavior, Animal / drug effects
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Brain Chemistry / drug effects
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Depression / psychology
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Dose-Response Relationship, Drug
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Fenclonine / pharmacology
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Hindlimb Suspension
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Hypothermia / chemically induced
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Hypothermia / pathology
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Male
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Mice
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Mice, Inbred ICR
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Monoamine Oxidase / metabolism
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Monoamine Oxidase Inhibitors
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Motor Activity / drug effects
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Norepinephrine / metabolism
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Norepinephrine / physiology*
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Resveratrol
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Serotonin / metabolism
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Serotonin / physiology*
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Stereotyped Behavior / drug effects
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Stilbenes / pharmacology*
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Swimming / psychology
Substances
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Antidepressive Agents
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Antioxidants
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Monoamine Oxidase Inhibitors
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Stilbenes
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Serotonin
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Monoamine Oxidase
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Apomorphine
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Resveratrol
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Fenclonine
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Norepinephrine