Click to search

Vitamin D and multiple sclerosis: an update.


Cantorna MT1.
Author information
  • 1The Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.


Nutr Rev. 2008 Oct;66(10 Suppl 2):S135-8. doi: 10.1111/j.1753-4887.2008.00097.x.



Observational studies document a positive relationship between vitamin D from the environment (sunlight or diet), circulating vitamin D status, and improved symptoms or prevention of multiple sclerosis (MS). Experimental animal models of MS reproduce the beneficial effects of vitamin D and 1,25(OH)(2)D(3). The geographical distribution of MS can be explained by both the hygiene hypothesis and the vitamin D hypothesis. It therefore seems more likely that both hypotheses may be correct and that there are interactions between multiple environmental factors like vitamin D and the rate of infection that might explain the etiology of MS. The effects of vitamin D on the immune system and in the CNS have begun to be described and there is some information on the mechanisms underlying the effects of vitamin D in MS. A need exists for better understanding of the interactions of the environmental factors on MS, communication with the physicians treating MS patients as to the benefits of vitamin D, and clinical interventions with both vitamin D and analogs of 1,25(OH)(2)D(3).


18844840 [PubMed - indexed for MEDLINE]


PMC3712128 Free full text
Blackwell Publishing: Free full text
 Citation 10 of 265 Back to results 
Standard PubMed