RefSeq summary
[WNK2] The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq].
RefSeq annotates one representative transcript (NM included in AceView variant.c), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 22 spliced variants .
AceView synopsis, each blue text links to tables and details
Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is
expressed at high level , 1.7 times the average gene in this release. The
sequence of this gene is defined by
201 GenBank accessions from 169 cDNA clones, some from brain (seen 19 times), eye (19), hippocampus (10), colon (9), cerebellum (8), lymph (7), uterus (7) and 78 other
tissues . We annotate
structural defects or features in 31 cDNA clones.
Alternative mRNA variants and regulation: The gene contains
49 distinct introns (47 gt-ag, 2 gc-ag). Transcription produces
28 different mRNAs , 22 alternatively spliced variants and 6 unspliced forms. There are 12 probable
alternative promotors , 5 non overlapping alternative last exons and 7 validated
alternative polyadenylation sites (see the
diagram ). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 8
cassette exons , overlapping exons with different boundaries, splicing versus retention of 3 introns. 1150 bp of this gene
are antisense to spliced gene C9orf129 , 752 to
lortoby , raising the possibility of regulated alternate expression.
Efficacy of translation may be reduced by the presence of a shorter translated product (
uORF ) initiating at an AUG upstream of the main open reading frame (in variant jAug10).
Function: There are
13 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to
diseases (Hypertension; Meningeal Neoplasms) and proposed to participate in
processes (intracellular protein kinase cascade, protein amino acid phosphorylation). Proteins are expected to have molecular
functions (protein binding, ATP binding, nucleotide binding, protein serine/threonine kinase activity, transferase activity) and to
localize in various compartments (membrane, nucleus). A putative
protein interactor has been described (ATXN1).
Protein coding potential: 17 spliced and 2 unspliced mRNAs putatively encode
good proteins , altogether
19 different isoforms (6 complete, 5 COOH complete, 8 partial ), some containing
domains Protein kinase domain, Protein tyrosine kinase [Pfam], some transmembrane domains, a N-myristoylation domain, a peroxisomal domain, a second peroximal domain, a coiled coil stretch
[Psort2] . The remaining 8 mRNA variants (5 spliced, 3 unspliced; 5 partial) appear not to encode good proteins. Finally proteins from this gene may be modulated by
acetylation; mono-methylation; phosphorylation; ubiquitination , as detailed at PhosphoSite.
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12 .
Map on chromosome 9, links to other databases and other names
Map: This gene WNK2 maps on chromosome 9, at 9q22.3 according to Entrez Gene. In AceView, it covers
138.23 kb , from 95947212 to 96085442 (NCBI 37, August 2010), on the direct strand.
Links to: , manual annotations from
GAD ,
PhosphoSite , the
SNP view, gene overviews from
Entrez Gene 65268 ,
GeneCards , expression data from
ECgene ,
UniGene , molecular and other annotations from
UCSC , or our
GOLD analysis.
The previous AceView annotation is
here .
Other names: The gene is also known as WNK2, RP11-165J3.2, PRKWNK2, KIAA1760, NY-CO-43, SDCCAG43, P/OKcl.13, LOC65268, swulo or skoytarby, loyteebo. It has been described as serine/threonine-protein kinase WNK2, antigen NY-CO-43, OTTHUMP00000196928, OTTHUMP00000196929, protein kinase with no lysine 2, protein kinase lysine-deficient 2, protein kinase, lysine deficient 2, serologically defined colon cancer antigen 43, mitogen-activated protein kinase kinase kinase.
EC number: This gene encodes protein number: 2.7.11.1.
Closest AceView homologs in other species
?
The closest mouse gene , according to BlastP, is the AceView gene
Wnk2 (e=5 10
-24 ).
The closest C.elegans gene , according to BlastP, is the AceView/WormGene
wnk-1 (e=0.031), which may contain interesting functional annotation.
The closest A.thaliana genes , according to BlastP, are the AceView genes
WNK2 (e=10
-71 ),
WNK3 (e=2 10
-71 ),
WNK7 (e=3 10
-71 ),
WNK6 (e=2 10
-70 ),
AT1G64630 (e=3 10
-69 ),
WNK8 (e=3 10
-69 ),
AT5G58340andWNK4 (e=10
-68 ),
WNK1 (e=6 10
-68 ),
WNK9 (e=2 10
-66 ),
WNK5 (e=4 10
-65 ), which may contain interesting functional annotation
WNK2
Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM
BAB
SkeletalMuscle
WholeBlood
CHP
Kidney
Liver
Lung
Spleen
CMC
CMM
Cerebellum
HUM
Brain
Colon
Heart
LymphNode
Ovary
Testis
JMI
BoneMarrow
MLM
OWL
PTM
RMC
RMI
Pituitary
SQM
Thymus
MST
SMY
RTL
3.82
0.45
10.1
5.79
37.6
26.6
23.2
65.5
0.68
0.45
0.96
1.35
23.2
5.40
15.3
0.05
0.14
13.3
10.1
2.05
0.96
0.63
0.16
4.71
2.35
1.26
9.41
6.65
6.21
10.8
8.78
5.79
10.8
0.39
0.24
0.22
0.72
0.07
26.6
8.78
0.15
1.91
0.32
30.6
8.19
1.66
5.40
0.07
5.79
8.78
21.6
4.39
14.3
12.4
0.08
6.21
5.40
9.41
0.14
0.83
6.21
4.71
2.70
1.18
0.08
3.10
0.24
26.6
0.24
0.59
2.52
2.19
1.66
5.04
0.16
1.66
6.21
4.71
10.8
4.39
4.71
11.6
0.21
1.66
0.12
0.10
2.90
2.35
1.55
0.08
0.63
0.15
10.8
6.65
0.18
10.1
0.14
1.45
0.59
10.8
0.14
0.32
0.15
5.40
0.78
1.26
0.42
4.39
3.33
8.78
1.78
7.13
5.04
7.13
0.63
0.17
2.52
2.19
2.90
3.33
8.19
0.19
2.90
4.71
0.22
1.10
0.10
4.39
5.40
3.33
0.22
0.55
0.22
2.70
1.91
0.78
0.45
1.66
13.3
6.65
0.59
1.10
Expression
quantiles
None
Weak
1
2
3
4
5
6
7
8
10
20
This gene
All genes
log2 distributions
RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to
NHPRTR project ).
- Primates:
Apes (
HUM : Human (Illumina BodyMap 2),
CHP : Chimpanzee),
Old World monkeys (
PTM : Pig-Tailed Macaque,
JMI Japanese Macaque,
RMI Rhesus Macaque Indian,
RMC Rhesus Macaque Chinese,
CMM Cynomolgus Macaque Mauritian,
CMC Cynomolgus Macaque Chinese,
BAB Olive Baboon,
SMY Sooty Mangabey);
New World monkeys (
MST common Marmoset,
SQM Squirrel Monkey,
OWL Owl Monkey); and
Lemurs (
MLM Mouse Lemur,
RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for
all genes (blue) and for
this gene (green) , in Magic index = log
2 (1000 sFPKM).
You may also examine the strand-specific
genome coverage plots on the experimental AceView/Magic hub at UCSC , by tissue or by species. Tracks may be
slow to load ; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
Read more...
About UCSC tracks: you may enjoy the plots for the summed coverage over all primates' libraries (top track), summarizing 3 terabases of stranded RNA-seq. Fragments mapping on the + strand of the genome (from genes on the + strand) are red (or dark), on minus strand blue (or light) and antisense transcribed areas are black or overlaid. The vertical scale for each track is self-adapting. Homozygous SNPs tracks are also presented.
About mapping: Primates body map RNA-seq data were stringently mapped to the human genome using the NCBI Magic pipeline. Normalized results are shown as significant FPKM (sFPKM), which includes corrections on F, K and M, computed from parameters measured directly in each RNA-seq experiment, to render the expression measures more significant and more robust to experimental biases. Only fragments with both reads mapped uniquely and over at least 80+80 bases ending with 8 exact bases on each side of each read, and facing each other in a single site or gene, are included in the computation of the sFPKM/index, in the coverage plots, and in the determination of homozygous SNPs (minimum coverage 10, minimum allele frequency 95%). But be aware that genes whose sequence evolved to become too distant from Human cannot be measured well, this bias can be appreciated in the per-species coverage plots at UCSC.
About libraries: For non-human primates, total RNA libraries used TruSeq, ribozero and the stranded UDG protocol. The human 2010 libraries used the polyA selected non-stranded protocol, with short reads (50, 75 or 50+50 bases); furthermore the insert lengths are larger in human than in the non-human primates (average insert size 187 bp in non-human primates versus 232 bp in human). These protocol differences may impact expression measures for the non polyadenylated genes (or genes with shorter or occasional polyA tails), for the pseudogenes or close gene families (specificity is reduced in humans due to shorter reads), and for the very short genes.
Complete gene on genome diagram:
Compact gene diagram
Gene WNK2
5'
3'
encoded on plus strand of chromosome 9 from 95,947,212 to 96,085,442
26673
28876
15077
23488
31892
1
20448
30985
a
26673
28876
15077
23488
31892
31055
20448
30985
b
26673
28876
15077
23488
31892
31055
20448
30985
49706
c
[NM]
2
3
159
15077
23488
31892
31055
1540
30985
d
26673
28876
3649
e
36
q
2108
f
u-u
g
vb
h-u
va-u
1
31892
ve
vf-u
l-u
49706
t
1
i
46
31055
vd
3574
2108
o
3240
j
31055
k
1540
30985
49706
n
30985
49706
m
428
p
30985
49706
r
30985
49706
s
3
1
vc
vg-u
10kb
0
681 bp exon
44085 bp [gt-ag] intron
4 GenBank accessions
26669 RNA-seq supporting reads
1199 UHR pooled cells
5845 Brain
19 Blood
19312 Neuroblastoma
294 Other
(also 3199 Primates bodymap)
173 bp exon
1019 bp [gt-ag] intron
9 GenBank accessions
18961 RNA-seq supporting reads
794 UHR pooled cells
4295 Brain
11 Blood
13542 Neuroblastoma
319 Other
(also 2051 Primates bodymap)
221 bp exon
3699 bp [gt-ag] intron
5 GenBank accessions
28871 RNA-seq supporting reads
1709 UHR pooled cells
6990 Brain
27 Blood
19755 Neuroblastoma
390 Other
(also 2777 Primates bodymap)
158 bp exon
3267 bp [gt-ag] intron
7 GenBank accessions
29931 RNA-seq supporting reads
1794 UHR pooled cells
7384 Brain
11 Blood
20391 Neuroblastoma
351 Other
(also 3612 Primates bodymap)
89 bp exon
1435 bp [gt-ag] intron
6 GenBank accessions
29380 RNA-seq supporting reads
1628 UHR pooled cells
6959 Brain
21 Blood
20344 Neuroblastoma
428 Other
(also 3451 Primates bodymap)
220 bp exon
7566 bp [gt-ag] intron
7 GenBank accessions
27659 RNA-seq supporting reads
1670 UHR pooled cells
6357 Brain
18 Blood
19017 Neuroblastoma
597 Other
(also 2593 Primates bodymap)
292 bp exon
5048 bp [gt-ag] intron
6 GenBank accessions
20678 RNA-seq supporting reads
1082 UHR pooled cells
4076 Brain
2 Blood
14976 Neuroblastoma
542 Other
(also 1210 Primates bodymap)
200 bp exon
3216 bp [gt-ag] intron
6 GenBank accessions
15968 RNA-seq supporting reads
830 UHR pooled cells
3101 Brain
11700 Neuroblastoma
337 Other
(also 172 Primates bodymap)
156 bp exon
493 bp [gt-ag] intron
6 GenBank accessions
15071 RNA-seq supporting reads
841 UHR pooled cells
2727 Brain
4 Blood
11342 Neuroblastoma
157 Other
(also 270 Primates bodymap)
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
684 bp exon
2199 bp [gt-ag] intron
6 GenBank accessions
22544 RNA-seq supporting reads
1218 UHR pooled cells
4926 Brain
2 Blood
16118 Neuroblastoma
280 Other
(also 599 Primates bodymap)
294 bp exon
562 bp [gt-ag] intron
8 GenBank accessions
24612 RNA-seq supporting reads
1518 UHR pooled cells
5978 Brain
10 Blood
16805 Neuroblastoma
301 Other
(also 1162 Primates bodymap)
50 bp exon
846 bp [gt-ag] intron
8 GenBank accessions
23480 RNA-seq supporting reads
1509 UHR pooled cells
5739 Brain
8 Blood
15938 Neuroblastoma
286 Other
(also 1040 Primates bodymap)
169 bp exon
182 bp [gt-ag] intron
12 GenBank accessions
29469 RNA-seq supporting reads
2004 UHR pooled cells
6967 Brain
8 Blood
20186 Neuroblastoma
304 Other
(also 1621 Primates bodymap)
117 bp exon
3712 bp [gt-ag] intron
15 GenBank accessions
31877 RNA-seq supporting reads
2084 UHR pooled cells
8049 Brain
10 Blood
21293 Neuroblastoma
441 Other
(also 1111 Primates bodymap)
171 bp exon
103 bp [gt-ag] intron
16 GenBank accessions
27522 RNA-seq supporting reads
1678 UHR pooled cells
6383 Brain
8 Blood
18985 Neuroblastoma
468 Other
(also 1689 Primates bodymap)
46 bp exon
561 bp [gt-ag] intron
14 GenBank accessions
35996 RNA-seq supporting reads
2344 UHR pooled cells
8943 Brain
11 Blood
24057 Neuroblastoma
641 Other
(also 1857 Primates bodymap)
120 bp exon
111 bp exon
19837 bp [gt-ag] intron
1 GenBank accession
833 bp exon
357 bp [gt-ag] intron
12 GenBank accessions
24291 RNA-seq supporting reads
1765 UHR pooled cells
6271 Brain
7 Blood
15929 Neuroblastoma
319 Other
(also 1118 Primates bodymap)
70 bp exon
2260 bp [gt-ag] intron
10 GenBank accessions
22102 RNA-seq supporting reads
1627 UHR pooled cells
5695 Brain
5 Blood
14463 Neuroblastoma
312 Other
(also 479 Primates bodymap)
89 bp exon
94 bp [gt-ag] intron
12 GenBank accessions
33662 RNA-seq supporting reads
2599 UHR pooled cells
9524 Brain
10 Blood
21056 Neuroblastoma
473 Other
(also 955 Primates bodymap)
683 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
789 bp [gt-ag] intron
8 GenBank accessions
19717 RNA-seq supporting reads
341 UHR pooled cells
5779 Brain
4 Blood
13201 Neuroblastoma
392 Other
(also 1329 Primates bodymap)
99 bp exon
6627 bp [gt-ag] intron
6 GenBank accessions
20442 RNA-seq supporting reads
292 UHR pooled cells
6731 Brain
13019 Neuroblastoma
400 Other
(also 1416 Primates bodymap)
45 bp exon
1506 bp [gt-ag] intron
9 GenBank accessions
29683 RNA-seq supporting reads
366 UHR pooled cells
9322 Brain
6 Blood
19479 Neuroblastoma
510 Other
(also 2560 Primates bodymap)
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
241 bp [gt-ag] intron
4 GenBank accessions
8749 RNA-seq supporting reads
554 UHR pooled cells
3274 Brain
4763 Neuroblastoma
158 Other
(also 423 Primates bodymap)
399 bp exon
4 accessions, some from eye (seen 2 times)
colon crypt epithelium (once)
lens (once), optic nerve (once)
399 bp exon
668 bp exon
668 bp exon
44085 bp [gt-ag] intron
4 GenBank accessions
26669 RNA-seq supporting reads
1199 UHR pooled cells
5845 Brain
19 Blood
19312 Neuroblastoma
294 Other
(also 3199 Primates bodymap)
173 bp exon
1019 bp [gt-ag] intron
9 GenBank accessions
18961 RNA-seq supporting reads
794 UHR pooled cells
4295 Brain
11 Blood
13542 Neuroblastoma
319 Other
(also 2051 Primates bodymap)
221 bp exon
3699 bp [gt-ag] intron
5 GenBank accessions
28871 RNA-seq supporting reads
1709 UHR pooled cells
6990 Brain
27 Blood
19755 Neuroblastoma
390 Other
(also 2777 Primates bodymap)
158 bp exon
3267 bp [gt-ag] intron
7 GenBank accessions
29931 RNA-seq supporting reads
1794 UHR pooled cells
7384 Brain
11 Blood
20391 Neuroblastoma
351 Other
(also 3612 Primates bodymap)
89 bp exon
1435 bp [gt-ag] intron
6 GenBank accessions
29380 RNA-seq supporting reads
1628 UHR pooled cells
6959 Brain
21 Blood
20344 Neuroblastoma
428 Other
(also 3451 Primates bodymap)
220 bp exon
7566 bp [gt-ag] intron
7 GenBank accessions
27659 RNA-seq supporting reads
1670 UHR pooled cells
6357 Brain
18 Blood
19017 Neuroblastoma
597 Other
(also 2593 Primates bodymap)
292 bp exon
5048 bp [gt-ag] intron
6 GenBank accessions
20678 RNA-seq supporting reads
1082 UHR pooled cells
4076 Brain
2 Blood
14976 Neuroblastoma
542 Other
(also 1210 Primates bodymap)
200 bp exon
3216 bp [gt-ag] intron
6 GenBank accessions
15968 RNA-seq supporting reads
830 UHR pooled cells
3101 Brain
11700 Neuroblastoma
337 Other
(also 172 Primates bodymap)
156 bp exon
493 bp [gt-ag] intron
6 GenBank accessions
15071 RNA-seq supporting reads
841 UHR pooled cells
2727 Brain
4 Blood
11342 Neuroblastoma
157 Other
(also 270 Primates bodymap)
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
684 bp exon
2199 bp [gt-ag] intron
6 GenBank accessions
22544 RNA-seq supporting reads
1218 UHR pooled cells
4926 Brain
2 Blood
16118 Neuroblastoma
280 Other
(also 599 Primates bodymap)
294 bp exon
562 bp [gt-ag] intron
8 GenBank accessions
24612 RNA-seq supporting reads
1518 UHR pooled cells
5978 Brain
10 Blood
16805 Neuroblastoma
301 Other
(also 1162 Primates bodymap)
50 bp exon
846 bp [gt-ag] intron
8 GenBank accessions
23480 RNA-seq supporting reads
1509 UHR pooled cells
5739 Brain
8 Blood
15938 Neuroblastoma
286 Other
(also 1040 Primates bodymap)
169 bp exon
182 bp [gt-ag] intron
12 GenBank accessions
29469 RNA-seq supporting reads
2004 UHR pooled cells
6967 Brain
8 Blood
20186 Neuroblastoma
304 Other
(also 1621 Primates bodymap)
117 bp exon
3712 bp [gt-ag] intron
15 GenBank accessions
31877 RNA-seq supporting reads
2084 UHR pooled cells
8049 Brain
10 Blood
21293 Neuroblastoma
441 Other
(also 1111 Primates bodymap)
171 bp exon
103 bp [gt-ag] intron
16 GenBank accessions
27522 RNA-seq supporting reads
1678 UHR pooled cells
6383 Brain
8 Blood
18985 Neuroblastoma
468 Other
(also 1689 Primates bodymap)
46 bp exon
561 bp [gt-ag] intron
14 GenBank accessions
35996 RNA-seq supporting reads
2344 UHR pooled cells
8943 Brain
11 Blood
24057 Neuroblastoma
641 Other
(also 1857 Primates bodymap)
120 bp exon
20041 bp [gt-ag] intron
14 GenBank accessions
31041 RNA-seq supporting reads
2102 UHR pooled cells
8335 Brain
6 Blood
20200 Neuroblastoma
398 Other
(also 1489 Primates bodymap)
833 bp exon
357 bp [gt-ag] intron
12 GenBank accessions
24291 RNA-seq supporting reads
1765 UHR pooled cells
6271 Brain
7 Blood
15929 Neuroblastoma
319 Other
(also 1118 Primates bodymap)
70 bp exon
2260 bp [gt-ag] intron
10 GenBank accessions
22102 RNA-seq supporting reads
1627 UHR pooled cells
5695 Brain
5 Blood
14463 Neuroblastoma
312 Other
(also 479 Primates bodymap)
89 bp exon
94 bp [gt-ag] intron
12 GenBank accessions
33662 RNA-seq supporting reads
2599 UHR pooled cells
9524 Brain
10 Blood
21056 Neuroblastoma
473 Other
(also 955 Primates bodymap)
683 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
789 bp [gt-ag] intron
8 GenBank accessions
19717 RNA-seq supporting reads
341 UHR pooled cells
5779 Brain
4 Blood
13201 Neuroblastoma
392 Other
(also 1329 Primates bodymap)
99 bp exon
6627 bp [gt-ag] intron
6 GenBank accessions
20442 RNA-seq supporting reads
292 UHR pooled cells
6731 Brain
13019 Neuroblastoma
400 Other
(also 1416 Primates bodymap)
45 bp exon
1506 bp [gt-ag] intron
9 GenBank accessions
29683 RNA-seq supporting reads
366 UHR pooled cells
9322 Brain
6 Blood
19479 Neuroblastoma
510 Other
(also 2560 Primates bodymap)
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
396 bp [gt-ag] intron
3 GenBank accessions
4120 RNA-seq supporting reads
254 UHR pooled cells
1517 Brain
3 Blood
2266 Neuroblastoma
80 Other
(also 174 Primates bodymap)
1316 bp exon
16 accessions, some from alveolar rhabdomyosarcoma (seen 2 times)
carcinoid (2), colon normal (2)
lung (2), uterus (2)
Validated 3' end, 1 accession
1316 bp exon
681 bp exon
44085 bp [gt-ag] intron
4 GenBank accessions
26669 RNA-seq supporting reads
1199 UHR pooled cells
5845 Brain
19 Blood
19312 Neuroblastoma
294 Other
(also 3199 Primates bodymap)
173 bp exon
1019 bp [gt-ag] intron
9 GenBank accessions
18961 RNA-seq supporting reads
794 UHR pooled cells
4295 Brain
11 Blood
13542 Neuroblastoma
319 Other
(also 2051 Primates bodymap)
221 bp exon
3699 bp [gt-ag] intron
5 GenBank accessions
28871 RNA-seq supporting reads
1709 UHR pooled cells
6990 Brain
27 Blood
19755 Neuroblastoma
390 Other
(also 2777 Primates bodymap)
158 bp exon
3267 bp [gt-ag] intron
7 GenBank accessions
29931 RNA-seq supporting reads
1794 UHR pooled cells
7384 Brain
11 Blood
20391 Neuroblastoma
351 Other
(also 3612 Primates bodymap)
89 bp exon
1435 bp [gt-ag] intron
6 GenBank accessions
29380 RNA-seq supporting reads
1628 UHR pooled cells
6959 Brain
21 Blood
20344 Neuroblastoma
428 Other
(also 3451 Primates bodymap)
220 bp exon
7566 bp [gt-ag] intron
7 GenBank accessions
27659 RNA-seq supporting reads
1670 UHR pooled cells
6357 Brain
18 Blood
19017 Neuroblastoma
597 Other
(also 2593 Primates bodymap)
292 bp exon
5048 bp [gt-ag] intron
6 GenBank accessions
20678 RNA-seq supporting reads
1082 UHR pooled cells
4076 Brain
2 Blood
14976 Neuroblastoma
542 Other
(also 1210 Primates bodymap)
200 bp exon
3216 bp [gt-ag] intron
6 GenBank accessions
15968 RNA-seq supporting reads
830 UHR pooled cells
3101 Brain
11700 Neuroblastoma
337 Other
(also 172 Primates bodymap)
156 bp exon
493 bp [gt-ag] intron
6 GenBank accessions
15071 RNA-seq supporting reads
841 UHR pooled cells
2727 Brain
4 Blood
11342 Neuroblastoma
157 Other
(also 270 Primates bodymap)
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
684 bp exon
2199 bp [gt-ag] intron
6 GenBank accessions
22544 RNA-seq supporting reads
1218 UHR pooled cells
4926 Brain
2 Blood
16118 Neuroblastoma
280 Other
(also 599 Primates bodymap)
294 bp exon
562 bp [gt-ag] intron
8 GenBank accessions
24612 RNA-seq supporting reads
1518 UHR pooled cells
5978 Brain
10 Blood
16805 Neuroblastoma
301 Other
(also 1162 Primates bodymap)
50 bp exon
846 bp [gt-ag] intron
8 GenBank accessions
23480 RNA-seq supporting reads
1509 UHR pooled cells
5739 Brain
8 Blood
15938 Neuroblastoma
286 Other
(also 1040 Primates bodymap)
169 bp exon
182 bp [gt-ag] intron
12 GenBank accessions
29469 RNA-seq supporting reads
2004 UHR pooled cells
6967 Brain
8 Blood
20186 Neuroblastoma
304 Other
(also 1621 Primates bodymap)
117 bp exon
3712 bp [gt-ag] intron
15 GenBank accessions
31877 RNA-seq supporting reads
2084 UHR pooled cells
8049 Brain
10 Blood
21293 Neuroblastoma
441 Other
(also 1111 Primates bodymap)
171 bp exon
103 bp [gt-ag] intron
16 GenBank accessions
27522 RNA-seq supporting reads
1678 UHR pooled cells
6383 Brain
8 Blood
18985 Neuroblastoma
468 Other
(also 1689 Primates bodymap)
46 bp exon
561 bp [gt-ag] intron
14 GenBank accessions
35996 RNA-seq supporting reads
2344 UHR pooled cells
8943 Brain
11 Blood
24057 Neuroblastoma
641 Other
(also 1857 Primates bodymap)
120 bp exon
20041 bp [gt-ag] intron
14 GenBank accessions
31041 RNA-seq supporting reads
2102 UHR pooled cells
8335 Brain
6 Blood
20200 Neuroblastoma
398 Other
(also 1489 Primates bodymap)
833 bp exon
357 bp [gt-ag] intron
12 GenBank accessions
24291 RNA-seq supporting reads
1765 UHR pooled cells
6271 Brain
7 Blood
15929 Neuroblastoma
319 Other
(also 1118 Primates bodymap)
70 bp exon
2260 bp [gt-ag] intron
10 GenBank accessions
22102 RNA-seq supporting reads
1627 UHR pooled cells
5695 Brain
5 Blood
14463 Neuroblastoma
312 Other
(also 479 Primates bodymap)
89 bp exon
94 bp [gt-ag] intron
12 GenBank accessions
33662 RNA-seq supporting reads
2599 UHR pooled cells
9524 Brain
10 Blood
21056 Neuroblastoma
473 Other
(also 955 Primates bodymap)
683 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
789 bp [gt-ag] intron
8 GenBank accessions
19717 RNA-seq supporting reads
341 UHR pooled cells
5779 Brain
4 Blood
13201 Neuroblastoma
392 Other
(also 1329 Primates bodymap)
99 bp exon
6627 bp [gt-ag] intron
6 GenBank accessions
20442 RNA-seq supporting reads
292 UHR pooled cells
6731 Brain
13019 Neuroblastoma
400 Other
(also 1416 Primates bodymap)
45 bp exon
1506 bp [gt-ag] intron
9 GenBank accessions
29683 RNA-seq supporting reads
366 UHR pooled cells
9322 Brain
6 Blood
19479 Neuroblastoma
510 Other
(also 2560 Primates bodymap)
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
206 bp exon
69 accessions, NM_006648.3
some from eye (seen 11 times)
hippocampus (7), brain (5)
colon (4), uterus (4)
Validated 3' end, 14 accessions
206 bp exon
35 bp exon
201 bp [gc-ag] intron
2 GenBank accessions
38 bp exon
24692 bp [gt-ag] intron
2 GenBank accessions
1 RNA-seq supporting reads
1 Neuroblastoma
(also 65 Primates bodymap)
173 bp exon
1019 bp [gt-ag] intron
9 GenBank accessions
18961 RNA-seq supporting reads
794 UHR pooled cells
4295 Brain
11 Blood
13542 Neuroblastoma
319 Other
(also 2051 Primates bodymap)
221 bp exon
3667 bp [gt-ag] intron
2 GenBank accessions
157 RNA-seq supporting reads
4 UHR pooled cells
33 Brain
120 Neuroblastoma
(also 30 Primates bodymap)
190 bp exon
190 bp exon
3267 bp [gt-ag] intron
7 GenBank accessions
29931 RNA-seq supporting reads
1794 UHR pooled cells
7384 Brain
11 Blood
20391 Neuroblastoma
351 Other
(also 3612 Primates bodymap)
89 bp exon
1435 bp [gt-ag] intron
6 GenBank accessions
29380 RNA-seq supporting reads
1628 UHR pooled cells
6959 Brain
21 Blood
20344 Neuroblastoma
428 Other
(also 3451 Primates bodymap)
220 bp exon
7566 bp [gt-ag] intron
7 GenBank accessions
27659 RNA-seq supporting reads
1670 UHR pooled cells
6357 Brain
18 Blood
19017 Neuroblastoma
597 Other
(also 2593 Primates bodymap)
292 bp exon
5048 bp [gt-ag] intron
6 GenBank accessions
20678 RNA-seq supporting reads
1082 UHR pooled cells
4076 Brain
2 Blood
14976 Neuroblastoma
542 Other
(also 1210 Primates bodymap)
200 bp exon
3216 bp [gt-ag] intron
6 GenBank accessions
15968 RNA-seq supporting reads
830 UHR pooled cells
3101 Brain
11700 Neuroblastoma
337 Other
(also 172 Primates bodymap)
156 bp exon
493 bp [gt-ag] intron
6 GenBank accessions
15071 RNA-seq supporting reads
841 UHR pooled cells
2727 Brain
4 Blood
11342 Neuroblastoma
157 Other
(also 270 Primates bodymap)
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
684 bp exon
2199 bp [gt-ag] intron
6 GenBank accessions
22544 RNA-seq supporting reads
1218 UHR pooled cells
4926 Brain
2 Blood
16118 Neuroblastoma
280 Other
(also 599 Primates bodymap)
294 bp exon
562 bp [gt-ag] intron
8 GenBank accessions
24612 RNA-seq supporting reads
1518 UHR pooled cells
5978 Brain
10 Blood
16805 Neuroblastoma
301 Other
(also 1162 Primates bodymap)
50 bp exon
846 bp [gt-ag] intron
8 GenBank accessions
23480 RNA-seq supporting reads
1509 UHR pooled cells
5739 Brain
8 Blood
15938 Neuroblastoma
286 Other
(also 1040 Primates bodymap)
169 bp exon
182 bp [gt-ag] intron
12 GenBank accessions
29469 RNA-seq supporting reads
2004 UHR pooled cells
6967 Brain
8 Blood
20186 Neuroblastoma
304 Other
(also 1621 Primates bodymap)
117 bp exon
3712 bp [gt-ag] intron
15 GenBank accessions
31877 RNA-seq supporting reads
2084 UHR pooled cells
8049 Brain
10 Blood
21293 Neuroblastoma
441 Other
(also 1111 Primates bodymap)
171 bp exon
103 bp [gt-ag] intron
16 GenBank accessions
27522 RNA-seq supporting reads
1678 UHR pooled cells
6383 Brain
8 Blood
18985 Neuroblastoma
468 Other
(also 1689 Primates bodymap)
46 bp exon
561 bp [gt-ag] intron
14 GenBank accessions
35996 RNA-seq supporting reads
2344 UHR pooled cells
8943 Brain
11 Blood
24057 Neuroblastoma
641 Other
(also 1857 Primates bodymap)
120 bp exon
20041 bp [gt-ag] intron
14 GenBank accessions
31041 RNA-seq supporting reads
2102 UHR pooled cells
8335 Brain
6 Blood
20200 Neuroblastoma
398 Other
(also 1489 Primates bodymap)
833 bp exon
357 bp [gt-ag] intron
12 GenBank accessions
24291 RNA-seq supporting reads
1765 UHR pooled cells
6271 Brain
7 Blood
15929 Neuroblastoma
319 Other
(also 1118 Primates bodymap)
70 bp exon
2260 bp [gt-ag] intron
10 GenBank accessions
22102 RNA-seq supporting reads
1627 UHR pooled cells
5695 Brain
5 Blood
14463 Neuroblastoma
312 Other
(also 479 Primates bodymap)
89 bp exon
94 bp [gt-ag] intron
12 GenBank accessions
33662 RNA-seq supporting reads
2599 UHR pooled cells
9524 Brain
10 Blood
21056 Neuroblastoma
473 Other
(also 955 Primates bodymap)
683 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
10260 bp [gt-ag] intron
3 GenBank accessions
1537 RNA-seq supporting reads
867 UHR pooled cells
64 Brain
6 Blood
594 Neuroblastoma
6 Other
(also 91 Primates bodymap)
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
1808 bp exon
1808 bp exon
Sequence gap 969 bp
7 accessions, some from testis (seen 2 times)
brain (once), duodenum
adenocarcinoma (once)
eye (once), retina (once)
capped 5' end, 1 accession
Validated 3' end, 1 accession
268 bp exon
668 bp exon
668 bp exon
44085 bp [gt-ag] intron
4 GenBank accessions
26669 RNA-seq supporting reads
1199 UHR pooled cells
5845 Brain
19 Blood
19312 Neuroblastoma
294 Other
(also 3199 Primates bodymap)
173 bp exon
1019 bp [gt-ag] intron
9 GenBank accessions
18961 RNA-seq supporting reads
794 UHR pooled cells
4295 Brain
11 Blood
13542 Neuroblastoma
319 Other
(also 2051 Primates bodymap)
221 bp exon
3699 bp [gt-ag] intron
5 GenBank accessions
28871 RNA-seq supporting reads
1709 UHR pooled cells
6990 Brain
27 Blood
19755 Neuroblastoma
390 Other
(also 2777 Primates bodymap)
158 bp exon
3267 bp [gt-ag] intron
7 GenBank accessions
29931 RNA-seq supporting reads
1794 UHR pooled cells
7384 Brain
11 Blood
20391 Neuroblastoma
351 Other
(also 3612 Primates bodymap)
89 bp exon
1435 bp [gt-ag] intron
6 GenBank accessions
29380 RNA-seq supporting reads
1628 UHR pooled cells
6959 Brain
21 Blood
20344 Neuroblastoma
428 Other
(also 3451 Primates bodymap)
220 bp exon
7566 bp [gt-ag] intron
7 GenBank accessions
27659 RNA-seq supporting reads
1670 UHR pooled cells
6357 Brain
18 Blood
19017 Neuroblastoma
597 Other
(also 2593 Primates bodymap)
292 bp exon
5048 bp [gt-ag] intron
6 GenBank accessions
20678 RNA-seq supporting reads
1082 UHR pooled cells
4076 Brain
2 Blood
14976 Neuroblastoma
542 Other
(also 1210 Primates bodymap)
200 bp exon
3865 bp [gt-ag] intron
1 GenBank accession
3648 RNA-seq supporting reads
77 UHR pooled cells
610 Brain
2892 Neuroblastoma
69 Other
(also 3 Primates bodymap)
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
145 bp exon
1 accession
145 bp exon
225 bp exon
225 bp exon
501 bp [gt-ag] intron
1 GenBank accession
35 RNA-seq supporting reads
30 UHR pooled cells
1 Blood
4 Neuroblastoma
70 bp exon
1 accession from lymph from lymphoma
cell line
70 bp exon
433 bp exon
357 bp [gt-ag] intron
12 GenBank accessions
24291 RNA-seq supporting reads
1765 UHR pooled cells
6271 Brain
7 Blood
15929 Neuroblastoma
319 Other
(also 1118 Primates bodymap)
70 bp exon
70 bp exon
2263 bp [gt-ag] intron
3 GenBank accessions
8975 RNA-seq supporting reads
711 UHR pooled cells
2520 Brain
1 Blood
5623 Neuroblastoma
120 Other
(also 112 Primates bodymap)
86 bp exon
94 bp [gt-ag] intron
12 GenBank accessions
33662 RNA-seq supporting reads
2599 UHR pooled cells
9524 Brain
10 Blood
21056 Neuroblastoma
473 Other
(also 955 Primates bodymap)
683 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
9066 bp [gt-ag] intron
2 GenBank accessions
2106 RNA-seq supporting reads
798 UHR pooled cells
383 Brain
18 Blood
894 Neuroblastoma
13 Other
(also 153 Primates bodymap)
257 bp exon
136 bp [gt-ag] intron
1 GenBank accession
2573 RNA-seq supporting reads
424 UHR pooled cells
552 Brain
5 Blood
1577 Neuroblastoma
15 Other
(also 82 Primates bodymap)
476 bp exon
8 accessions, some from brain (seen 2 times)
colon (2), blood (once)
colon cancer metastasis to lung (once)
colon tumor (once)
capped 5' end, 1 accession
Validated 3' end, 1 accession
476 bp exon
923 bp exon
923 bp exon
5 accessions, some from burkitt lymphoma (seen 4 times)
lymph (4), cartilage (once)
923 bp exon
455 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
789 bp [gt-ag] intron
8 GenBank accessions
19717 RNA-seq supporting reads
341 UHR pooled cells
5779 Brain
4 Blood
13201 Neuroblastoma
392 Other
(also 1329 Primates bodymap)
280 bp exon
2 accessions, some from whole brain (seen 2 times)
280 bp exon
679 bp exon
679 bp exon
396 bp [gt-ag] intron
3 GenBank accessions
4120 RNA-seq supporting reads
254 UHR pooled cells
1517 Brain
3 Blood
2266 Neuroblastoma
80 Other
(also 174 Primates bodymap)
124 bp exon
1 accession from skin
124 bp exon
2170 bp exon
2170 bp exon
6 accessions, some from eye (seen 3 times)
fetal eyes, lens, eye anterior segment
optic nerve, retina, retina foveal and macular
RPE andchoroid (3), small intestine (2)
testis (once)
capped 5' end, 1 accession
2170 bp exon
860 bp exon
860 bp exon
1 accession from sciatic nerve
860 bp exon
58 bp exon
241 bp [gt-ag] intron
1 GenBank accession
(also 2 Primates bodymap)
169 bp exon
182 bp [gt-ag] intron
12 GenBank accessions
29469 RNA-seq supporting reads
2004 UHR pooled cells
6967 Brain
8 Blood
20186 Neuroblastoma
304 Other
(also 1621 Primates bodymap)
117 bp exon
117 bp exon
3712 bp [gt-ag] intron
15 GenBank accessions
31877 RNA-seq supporting reads
2084 UHR pooled cells
8049 Brain
10 Blood
21293 Neuroblastoma
441 Other
(also 1111 Primates bodymap)
171 bp exon
103 bp [gt-ag] intron
16 GenBank accessions
27522 RNA-seq supporting reads
1678 UHR pooled cells
6383 Brain
8 Blood
18985 Neuroblastoma
468 Other
(also 1689 Primates bodymap)
1 accession from cerebellum
capped 5' end, 1 accession
21 bp exon
204 bp exon
204 bp exon
1 accession
204 bp exon
683 bp exon
683 bp exon
4 accessions, some from pancreas (seen 4 times)
purified pancreatic islet (4)
683 bp exon
2143 bp exon
2143 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
200 bp exon
16 accessions, some from thalamus (seen 2 times)
trachea (2), brain (once)
cerebellum (once), colon (once)
Validated 3' end, 2 accessions
200 bp exon
43 bp exon
43 bp exon
178 bp [gt-ag] intron
1 GenBank accession
192 bp exon
1791 bp [gt-ag] intron
8 GenBank accessions
22471 RNA-seq supporting reads
1214 UHR pooled cells
4816 Brain
7 Blood
15948 Neuroblastoma
486 Other
(also 661 Primates bodymap)
321 bp exon
1 accession from testis
capped 5' end, 1 accession
321 bp exon
39 bp exon
98 bp [gt-ag] intron
1 GenBank accession
45 RNA-seq supporting reads
2 UHR pooled cells
5 Brain
37 Neuroblastoma
1 Other
(also 2 Primates bodymap)
46 bp exon
561 bp [gt-ag] intron
14 GenBank accessions
35996 RNA-seq supporting reads
2344 UHR pooled cells
8943 Brain
11 Blood
24057 Neuroblastoma
641 Other
(also 1857 Primates bodymap)
120 bp exon
20041 bp [gt-ag] intron
14 GenBank accessions
31041 RNA-seq supporting reads
2102 UHR pooled cells
8335 Brain
6 Blood
20200 Neuroblastoma
398 Other
(also 1489 Primates bodymap)
344 bp exon
1 accession from tongue
tumor tissue
capped 5' end, 1 accession
344 bp exon
129 bp exon
129 bp exon
1056 bp [gc-ag] intron
1 GenBank accession
3573 RNA-seq supporting reads
151 UHR pooled cells
1422 Brain
1951 Neuroblastoma
49 Other
192 bp exon
9066 bp [gt-ag] intron
2 GenBank accessions
2106 RNA-seq supporting reads
798 UHR pooled cells
383 Brain
18 Blood
894 Neuroblastoma
13 Other
(also 153 Primates bodymap)
1 accession from epidermis
50 bp exon
91 bp exon
91 bp exon
30 bp uORF
91 bp exon
91 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
215 bp exon
1002 bp [gt-ag] intron
11 GenBank accessions
23889 RNA-seq supporting reads
1080 UHR pooled cells
7066 Brain
7 Blood
15312 Neuroblastoma
424 Other
(also 1327 Primates bodymap)
192 bp exon
192 bp exon
7515 bp [gt-ag] intron
1 GenBank accession
3239 RNA-seq supporting reads
42 UHR pooled cells
1375 Brain
1744 Neuroblastoma
78 Other
(also 155 Primates bodymap)
45 bp exon
45 bp exon
1506 bp [gt-ag] intron
9 GenBank accessions
29683 RNA-seq supporting reads
366 UHR pooled cells
9322 Brain
6 Blood
19479 Neuroblastoma
510 Other
(also 2560 Primates bodymap)
10 bp exon
10 bp exon
1 accession from brain
capped 5' end, 1 accession
10 bp exon
236 bp exon
236 bp exon
20041 bp [gt-ag] intron
14 GenBank accessions
31041 RNA-seq supporting reads
2102 UHR pooled cells
8335 Brain
6 Blood
20200 Neuroblastoma
398 Other
(also 1489 Primates bodymap)
1 accession from thymus
capped 5' end, 1 accession
296 bp exon
76 bp exon
10260 bp [gt-ag] intron
3 GenBank accessions
1537 RNA-seq supporting reads
867 UHR pooled cells
64 Brain
6 Blood
594 Neuroblastoma
6 Other
(also 91 Primates bodymap)
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
2794 bp exon
5 accessions, some from brain (seen 3 times)
fetal brain (once), human embryonic stem cells (once)
lung (once), metastatic chondrosarcoma (once)
Validated 3' end, 1 accession
2794 bp exon
2117 bp exon
2117 bp exon
30 bp uORF
2117 bp exon
2117 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
112 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
198 bp exon
198 bp exon
9 accessions, some from amygdala (seen 2 times)
trachea (2), bladder (once)
head neck (once), testis (once)
198 bp exon
41 bp exon
4679 bp [gt-ag] intron
20 GenBank accessions
35497 RNA-seq supporting reads
2613 UHR pooled cells
9987 Brain
6 Blood
22182 Neuroblastoma
709 Other
(also 2247 Primates bodymap)
215 bp exon
1983 bp [gt-ag] intron
1 GenBank accession
427 RNA-seq supporting reads
16 UHR pooled cells
32 Brain
378 Neuroblastoma
1 Other
(also 10 Primates bodymap)
99 bp exon
1 accession from astrocytoma from brain
99 bp exon
61 bp exon
1506 bp [gt-ag] intron
9 GenBank accessions
29683 RNA-seq supporting reads
366 UHR pooled cells
9322 Brain
6 Blood
19479 Neuroblastoma
510 Other
(also 2560 Primates bodymap)
257 bp exon
257 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
217 bp exon
1 accession from cerebellum
capped 5' end, 1 accession
217 bp exon
1030 bp exon
1030 bp exon
1030 bp exon
Sequence gap 2612 bp
66 bp exon
8935 bp [gt-ag] intron
28 GenBank accessions
30957 RNA-seq supporting reads
1490 UHR pooled cells
7239 Brain
8 Blood
21792 Neuroblastoma
428 Other
(also 770 Primates bodymap)
112 bp exon
2735 bp [gt-ag] intron
33 GenBank accessions
49673 RNA-seq supporting reads
2712 UHR pooled cells
9050 Brain
18 Blood
37736 Neuroblastoma
157 Other
(also 1697 Primates bodymap)
4 accessions, some from adipose (seen once)
brain (once), eye (once)
lung (once), small cell carcinoma (once)
Validated 3' end, 1 accession
198 bp exon
21 bp exon
21 bp exon
793 bp [gt-ag] intron
2 GenBank accessions
1 RNA-seq supporting reads
1 Neuroblastoma
535 bp exon
535 bp exon
10191 bp [gt-ag] intron
1 GenBank accession
1 accession
102 bp exon
181 bp exon
1 accession from colon normal
181 bp exon
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Read more...
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Details on tissue of origin for each intron and exon is available from the
intron and exons table .
Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
Sequences: click on the numbers to get the DNA
Gene neighbors and Navigator on chromosome 9q22.3
WNK2
D
C
I
R
P
C
R
C
R
C9orf129
10
20kb
0
WNK2, 184 accessions, 28 variants
lawtoby, 1 accession
fysubu, 1 accession
kloyplarbu, 3 accessions
leytoby, 1 accession
romure, 3 accessions
glaplabu, 2 accessions
fosubu, 2 accessions
matoby, 1 accession
mytoby, 2 accessions
motoby, 1 accession
feysubu, 1 accession
mortoby, 11 accessions
swarlo, 5 accessions
jusubu, 1 accession
zostey, 1 accession
leetoby, 1 accession
zorstey, 1 accession
cherstey, 1 accession
rokiro, 2 accessions
kumumu, 1 accession
plyplarbu, 3 accessions
loytoby, 1 accession
martoby, 1 accession
mawtoby, 5 accessions
woshee, 2 accessions
meetoby, 1 accession
garsubu, 1 accession
mertoby, 2 accessions
ploplarbu, 1 accession
moytoby, 1 accession
natoby, 1 accession
nytoby, 2 accessions
plawplarbu, 1 accession
nutoby, 1 accession
swalo, 1 accession
lortoby, 4 accessions
2 variants
C9orf129, 18 accessions
3 variants
ZOOM OUT
D :disease,
C :conserved,
I :interactions,
R :regulation,
P :publications
Read more...
ANKRD19
C
R
P
G
FGD3
C
R
P
SUSD3
C
R
P
C9orf89
C
I
R
P
C
R
WNK2
D
C
I
R
P
FAM120A
C
R
P
PHF2
C
R
P
R
C
EEF1DP2
C
I
R
P
ZNF484
R
R
C
D
C
I
R
P
NINJ1
C
R
C
R
C9orf129
R
P
FAM120AOS
C
C
100kb
0
ANKRD19, 59 accessions
13 variants
LOC642959, 1 accession
FGD3, 264 accessions, 21 variants
SUSD3, 106 accessions
12 variants
C9orf89, 222 accessions
13 variants
steylo, 2 accessions, 2 variants
WNK2, 184 accessions, 28 variants
FAM120A, 586 accessions
12 variants
PHF2, 245 accessions, 8 variants
fleeplarbu, 1 accession
glaplarbu, 4 accessions
glyplarbu, 2 accessions
lorteebo, 1 accession
jotoby, 3 accessions
gleeplarbu, 1 accession
jartoby, 2 accessions
cheygar, 3 accessions
dosubu, 1 accession
gloyplarbu, 3 accessions
klyplarbu, 1 accession
joytoby, 1 accession
kluplarbu, 1 accession
kytoby, 1 accession
sumumu, 3 accessions
semumu, 1 accession
somumu, 1 accession
vastey, 3 accessions
kartoby, 1 accession
dawsubu, 1 accession
kamumu, 2 accessions, 2 variants
kawtoby, 1 accession
klarplarbu, 1 accession
kertoby, 1 accession
kortoby, 1 accession
klawplarbu, 1 accession
kimumu, 1 accession
zustey, 1 accession
kleyplarbu, 1 accession
latoby, 2 accessions
dorsubu, 1 accession
klertarby, 1 accession
doysubu, 1 accession
lawtoby, 1 accession
fysubu, 1 accession
kloyplarbu, 3 accessions
leytoby, 1 accession
romure, 3 accessions
glaplabu, 2 accessions
fosubu, 2 accessions
matoby, 1 accession
mytoby, 2 accessions
motoby, 1 accession
feysubu, 1 accession
mortoby, 11 accessions
swarlo, 5 accessions
jusubu, 1 accession
jarsubu, 1 accession
pleeplarbu, 4 accessions
plerplarbu, 1 accession
kemumu, 2 accessions, 2 variants
jeysubu, 1 accession
nawtoby, 1 accession
sharstey, 1 accession
neytoby, 1 accession
nortoby, 1 accession
koysubu, 1 accession
lawsubu, 1 accession
komumu, 5 accessions, 2 variants
skaplarbu, 1 accession
musubu, 1 accession
partoby, 2 accessions
norsubu, 1 accession
peetoby, 5 accessions
mateebo, 1 accession
poytoby, 1 accession
rytoby, 1 accession
swoylo, 2 accessions
sheestey, 1 accession
rertoby, 43 accessions
reytoby, 4 accessions
noysubu, 1 accession
pysubu, 1 accession
skoplarbu, 9 accessions
boysyby, 2 accessions
yakiro, 1 accession
rortoby, 1 accession
posubu, 1 accession
roytoby, 2 accessions
sytoby, 1 accession
rysubu, 2 accessions
seetoby, 2 accessions
sertoby, 1 accession
skerplarbu, 1 accession
bolar, 5 accessions
soytoby, 1 accession
rarsubu, 1 accession
yukiro, 2 accessions
rawsubu, 1 accession
myteebo, 1 accession
slyplarbu, 1 accession
worshee, 8 accessions
goytoby, 1 accession
sustey, 1 accession
speylo, 7 accessions
seestey, 1 accession
swarsybu, 1 accession
fleyplarbu, 1 accession
jytoby, 2 accessions
floyplarbu, 1 accession
gluplarbu, 1 accession
swoysybu, 1 accession
zartarby, 2 accessions
bysubu, 3 accessions
glerplarbu, 1 accession
jeytoby, 1 accession
jortoby, 1 accession
gleyplarbu, 1 accession
glorplarbu, 1 accession
klaplarbu, 1 accession
torstey, 1 accession
blatarby, 3 accessions
darsubu, 1 accession
kutoby, 7 accessions
stylo, 2 accessions
vystey, 1 accession
veestey, 5 accessions
keytoby, 1 accession
kleeplarbu, 2 accessions
sushi.4, 6 accessions
rukiro, 17 accessions
deesubu, 1 accession
klorplarbu, 2 accessions
lutoby, 2 accessions
lotoby, 4 accessions
klotarby, 6 accessions
rekiro, 1 accession
zostey, 1 accession
leetoby, 1 accession
zorstey, 1 accession
cherstey, 1 accession
rokiro, 2 accessions
kumumu, 1 accession
plyplarbu, 3 accessions
loytoby, 1 accession
martoby, 1 accession
mawtoby, 5 accessions
woshee, 2 accessions
meetoby, 1 accession
garsubu, 1 accession
mertoby, 2 accessions
ploplarbu, 1 accession
moytoby, 1 accession
natoby, 1 accession
nytoby, 2 accessions
plawplarbu, 1 accession
nutoby, 1 accession
joysubu, 1 accession
nartoby, 1 accession
wawshee, 3 accessions
plorplarbu, 1 accession
nertoby, 1 accession
noytoby, 1 accession
patoby, 1 accession
leysubu, 1 accession
mysubu, 1 accession
putoby, 5 accessions
mawsubu, 1 accession
nysubu, 1 accession
peytoby, 1 accession
sworlo, 1 accession
skuplarbu, 1 accession
ratoby, 1 accession
rutoby, 1 accession
rotoby, 1 accession
pusubu, 1 accession
satoby, 1 accession
wershee, 3 accessions
persubu, 1 accession
rasubu, 1 accession
skeeplarbu, 1 accession
sotoby, 1 accession
sartoby, 1 accession
sawtoby, 1 accession
seytoby, 1 accession
skeyplarbu, 1 accession
skorplarbu, 2 accessions
rusubu, 1 accession
skoyplarbu, 2 accessions
tatoby, 3 accessions
flerstey, 1 accession
meereyby, 1 accession
sluplarbu, 1 accession
BICD2, 298 accessions
2 variants
kesiro, 3 accessions, 3 variants
EEF1DP2, 34 accessions
ZNF484, 61 accessions
12 variants
marreyby, 4 accessions
starlo, 10 accessions
3 variants
flertarby, 1 accession
NINJ1, 273 accessions
5 variants
swalo, 1 accession
lortoby, 4 accessions
2 variants
C9orf129, 18 accessions
3 variants
FAM120AOS, 370 accessions
21 variants
kasubu, 1 accession
sortoby, 1 accession
ZOOM IN
D :disease,
C :conserved,
I :interactions,
R :regulation,
P :publications
Read more...
Annotated mRNA diagrams
The mRNAs diagrams with the aligned cDNA sequence accessions and their mismatches are available in the mRNA pages accessible from the tab at the top of the page, or here:
In Flash:
.b , .c , .t , .e , .f , .a , .n , .h-u , .m , .d , .u-u , .vg-u , .r , .ve , .g , .s , .vd , .o , .j , .p , .vb , .q , .l-u , .vf-u , .i , .k , .vc .
or in GIF:
.b , .c , .t , .e , .f , .a , .n , .h-u , .m , .d , .u-u , .vg-u , .r , .ve , .g , .s , .vd , .o , .j , .p , .vb , .q , .l-u , .vf-u , .i , .k , .vc
Bibliography:   13 articles in PubMed
? Gene Summary
Gene on genome
mRNA: .a , .b , .c , .d , .e , .f , .g , .h-u , .i , .j , .k , .l-u , .m , .n , .o , .p , .q , .r , .s , .t , .u-u , .va-u , .vb , .vc , .vd , .ve , .vf-u , .vg-u
Alternative mRNAs features, proteins, introns, exons, sequences
Expression Tissue
Function, regulation, related genes D C I
To
mine knowledge about the gene, please click the
'Gene Summary' or the
'Function, regulation, related genes ' tab at the top of the page. The
'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The
'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To
compare alternative variants , their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the
'Alternative mRNAs features' tab. To see a
specific mRNA variant diagram, sequence and annotation, click the variant name in the
'mRNA' tab. To examine
expression data from all cDNAs clustered in this gene by AceView, click the
'Expression tissue' .
If you know more about this gene, or found errors, please
share your knowledge. Thank you !