Homo sapiens gene KRTAP5-5, encoding keratin associated protein 5-5.
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SUMMARY back to top
RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is expressed at low level, only 2.8% of the average gene in this release. The sequence of this gene is defined by 5 GenBank accessions from 4 cDNA clones, some from hair roots (seen once), heart (once), scalp (once).
Function: There is one article specifically referring to this gene in PubMed. Proteins are expected to localize in keratin filament. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.
. This gene contains a peroxisomal domain [Psort2], apparently Homo sapiens specific.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 11, links to other databases and other names
Map: This gene KRTAP5-5 maps on chromosome 11, at 11p15.5 according to Entrez Gene. In AceView, it covers 1.16 kb, from 1651005 to 1652160 (NCBI 37, August 2010), on the direct strand.
Links to: the SNP view, gene overviews from Entrez Gene 439915, GeneCards, expression data from UniGene Hs.653467, Hs.673618, molecular and other annotations from UCSC. The previous AceView annotation is here.
Other names: The gene is also known as KRTAP5-5, KRTAP5.5 or KRTAP5-11, LOC439915. It has been described as keratin-associated protein 5-5, keratin-associated protein 5.5, keratin associated protein 5-11, keratin-associated protein 5-11, keratin-associated protein 5.11, ultrahigh sulfur keratin-associated protein 5.5.
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
KRTAP5-5 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 2.90 1.10 0.15 0.19 0.18 1.55 1.26 0.26 0.15 0.21 0.59 0.15 0.11 0.16 2.19 0.26 0.17 0.18 0.15 0.24 1.02 0.22 0.59 0.13 0.21 0.10 0.29 0.48 0.22 0.21 0.59 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene KRTAP5-5 5' 3' encoded on plus strand of chromosome 11 from 1,651,005 to 1,652,160 100bp 0 1156 bp exon 1156 bp exon Validated 3' end, 1 accession 1156 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10-unspliced 1156 bp 237 aa 66 bp 376 bp 2kb 1156 bp 1kb

Gene neighbors and Navigator on chromosome 11p15.5 back to top
C R MUC5ACandMUC5B D C I R P G R BRSK2 C I R P G R P KRTAP5-5 P FAM99A R KRTAP5-6 P R SYT8 C I R P TNNI2 D C I R P LSP1 D C I R P TNNT3 D C I R P MRPL23 C I R P C R R D C I R P TOLLIP D C I R P MOB2 D C R P DUSP8 D P KRTAP5-1 P KRTAP5-2 P KRTAP5-3 P KRTAP5-4 R FAM99B D C I R P CTSD G R P D R P H19 100kb 0 torglaw, 18 accessions toyglaw, 85 accessions 2 variants MUC5ACandMUC5B, 292 accessions 5 variants LOC255512, 33 accessions BRSK2, 118 accessions 19 variants LOC338651, 24 accessions 4 variants merure, 6 accessions KRTAP5-5, 4 accessions FAM99A, 6 accessions, 2 variants KRTAP5-6, 5 accessions glytubo, 7 accessions SYT8, 63 accessions, 15 variants TNNI2, 245 accessions 4 variants LSP1, 506 accessions, 23 variants TNNT3, 337 accessions 21 variants MRPL23, 238 accessions 11 variants feefoyby, 9 accessions geygler, 3 accessions plorferby, 1 accession forchoy, 1 accession bawkeeby, 1 accession beekeeby, 2 accessions varslyby, 1 accession beykeeby, 1 accession borkeeby, 1 accession boykeeby, 2 accessions sherslyby, 1 accession kiyoro, 3 accessions staflawbu, 1 accession skumee, 2 accessions styflawbu, 1 accession lawgler, 1 accession stawflawbu, 1 accession blawslyby, 1 accession kleeslyby, 1 accession deykeeby, 1 accession dorkeeby, 1 accession smoyslyby, 2 accessions sneeslyby, 3 accessions tatumi, 2 accessions, 2 variants fykeeby, 1 accession kuyoro, 1 accession nagler, 2 accessions fukeeby, 2 accessions stoyflawbu, 5 accessions swarflawbu, 1 accession nawgler, 1 accession skarmar, 9 accessions 2 variants skawmar, 4 accessions plerfee, 1 accession gukeeby, 2 accessions merchee, 2 accessions sweeflawbu, 2 accessions spuslyby, 1 accession skeemar, 14 accessions geykeeby, 1 accession gorkeeby, 1 accession rugler, 1 accession sagler, 1 accession ramaro, 1 accession glotubo, 1 accession ramee, 1 accession gorsha, 3 accessions rarmee, 1 accession bleetubo, 3 accessions garsluby, 1 accession tagler, 1 accession rarsha, 7 accessions jorkeeby, 1 accession rumaro, 1 accession torgler, 1 accession zugler, 2 accessions zargler, 1 accession korsluby, 1 accession swoykawby, 1 accession gorgler, 3 accessions jagler, 1 accession jugler, 1 accession bokeeby, 1 accession foychoy, 2 accessions skoferby, 3 accessions swamoy, 2 accessions barkeeby, 2 accessions jeegler, 1 accession suyoro, 1 accession cheeslyby, 8 accessions berkeeby, 2 accessions plufee, 3 accessions swomoy, 3 accessions jergler, 1 accession kugler, 1 accession dakeeby, 2 accessions dykeeby, 1 accession bloslyby, 3 accessions darkeeby, 2 accessions dawkeeby, 1 accession lergler, 1 accession moygler, 1 accession smaforby, 1 accession deekeeby, 3 accessions notumi, 2 accessions, 2 variants kloyslyby, 2 accessions plarfee, 1 accession plawslyby, 1 accession skoyslyby, 1 accession fakeeby, 1 accession fokeeby, 1 accession fawkeeby, 1 accession feekeeby, 2 accessions ferkeeby, 1 accession swuflawbu, 2 accessions forkeeby, 2 accessions gakeeby, 1 accession nergler, 2 accessions wamaro, 1 accession spaforby, 5 accessions steeslyby, 1 accession garkeeby, 7 accessions gawkeeby, 5 accessions stoyslyby, 1 accession gerkeeby, 1 accession morchee, 1 accession swerflawbu, 2 accessions moychee, 1 accession basluby, 1 accession goykeeby, 1 accession porgler, 1 accession rawgler, 1 accession glutubo, 1 accession seygler, 1 accession sorgler, 1 accession bersluby, 1 accession glartubo, 1 accession jarkeeby, 1 accession jawkeeby, 1 accession josluby, 1 accession jerkeeby, 1 accession joykeeby, 1 accession tawgler, 1 accession teygler, 1 accession wagler, 2 accessions wergler, 1 accession blaflobu, 2 accessions 2 variants glyforby, 17 accessions 2 variants TOLLIP, 503 accessions 11 variants MOB2, 250 accessions, 9 variants DUSP8, 74 accessions, 3 variants KRTAP5-1, 2 accessions KRTAP5-2, 5 accessions KRTAP5-3, 4 accessions KRTAP5-4, 3 accessions FAM99B, 8 accessions, 2 variants CTSD, 457 accessions, 12 variants LOC100133545, 5 accessions H19, 523 accessions, 10 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               1 article in PubMed back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !