Homo sapiens gene CSF2RB, encoding colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage).
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SUMMARY back to top
RefSeq summary
[CSF2RB] The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq].

RefSeq annotates one representative transcript (NM included in AceView variant.b), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 4 spliced variants.

AceView synopsis, each blue text links to tables and details
Expression: According to AceView, this gene is well expressed, 1.3 times the average gene in this release. The sequence of this gene is defined by 144 GenBank accessions from 132 cDNA clones, some from placenta (seen 15 times), placenta normal (10), lymph (5), placenta cot 25-normalized (5), germinal center B cell (4), leukopheresis (4), aorta (3) and 32 other tissues. We annotate structural defects or features in 2 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 16 distinct gt-ag introns. Transcription produces 5 different mRNAs, 4 alternatively spliced variants and 1 unspliced form. There are 4 probable alternative promotors and 3 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, overlapping exons with different boundaries.
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant aAug10).
Function: There are 71 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (OMIM: Surfactant metabolism dysfunction, pulmonary, 1; Other sources: Asthma; Bronchial Hyperreactivity; Cell Transformation, Neoplastic; Hypersensitivity, Immediate; Pulmonary alveolar proteinosis; Rhinitis, Allergic, Seasonal; Translocation, Genetic) and proposed to participate in pathways (Apoptosis, Cytokine-cytokine receptor interaction, IL 3 signaling pathway, Jak-STAT signaling pathway, Regulation of BAD phosphorylation). Proteins are expected to have molecular function (receptor activity) and to localize in membrane. Putative protein interactors have been described (CISH, CSF2, CSF2RA, CSF2RA.1, CSF2RB, FES, FYN, GNB2L1ANDSNORD95ANDSNORD96A, HCK, IL3, IL3RA, IL3RA.1, IL5RA, JAK1, JAK2, KDR, KIT, LCK, LYN, MAD2L1, PRKCB, PTPN6, PTPN11, RGL3ANDEPOR, SHC1ANDPYGO2ANDPBXIP1, STAT1, STAT3, SYK, YWHAZ).
Protein coding potential: 4 spliced mRNAs putatively encode good proteins, altogether 4 different isoforms (3 complete, 1 partial), some containing Fibronectin type III domain [Pfam], some transmembrane domains [Psort2], apparently vertebrate specific. The remaining mRNA variant (unspliced; partial) appears not to encode a good protein. Finally proteins from this gene may be modulated by phosphorylation, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 22, links to other databases and other names
Map: This gene CSF2RB maps on chromosome 22, at 22q13.1 according to Entrez Gene. In AceView, it covers 26.83 kb, from 37309669 to 37336494 (NCBI 37, August 2010), on the direct strand.
Links to: manual annotations from OMIM_265120, GAD, KEGG_04060, KEGG_04210, KEGG_04630, PhosphoSite, the SNP view, gene overviews from Entrez Gene 1439, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as CSF2RB, CITF22-45C1.4, CD131, IL3RB, IL5RB or CDw131, LOC1439. It has been described as cytokine receptor common subunit beta, OTTHUMP00000197802, GM-CSF/IL-3/IL-5 receptor common beta-chain, GM-CSF/IL-3/IL-5 receptor common beta subunit, colony-stimulating factor-2 receptor, beta, low-affinity, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity).
Closest AceView homologs in other species ?
The closest mouse genes, according to BlastP, are the AceView genes Csf2rb2 (e=0.0), Csf2rb (e=0.0)
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
CSF2RB Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 0.22 13.3 5.40 1.45 18.8 0.72 17.6 43.2 17.6 17.6 1.26 2.52 2.35 1.26 1.26 13.3 24.8 0.26 2.70 2.05 114 6.65 7.13 5.79 10.1 24.8 5.79 21.6 2.90 1.91 1.91 37.6 0.24 0.96 2.70 0.83 0.48 0.96 13.3 17.6 75.3 0.11 0.55 0.19 0.12 0.07 2.35 0.26 0.45 0.63 0.29 5.04 6.65 0.51 3.57 17.6 0.17 0.18 0.16 3.57 0.32 0.18 0.08 3.57 13.3 6.21 2.90 10.8 0.22 3.10 0.39 0.08 2.05 7.13 0.16 9.41 2.52 0.24 0.39 0.21 0.13 3.82 0.32 0.21 0.42 3.57 4.39 0.27 8.19 2.70 3.10 2.70 0.96 1.26 0.78 3.82 0.45 6.21 2.52 1.78 0.12 5.40 0.48 9.41 0.13 0.55 0.12 18.8 10.1 2.05 0.14 2.70 0.26 0.18 0.55 0.18 1.55 0.55 16.4 1.66 3.82 0.42 11.6 8.78 0.48 13.3 3.57 0.07 0.18 0.12 0.27 0.45 4.71 0.22 7.64 2.90 0.36 0.11 0.21 7.64 6.65 2.52 1.78 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene CSF2RB 5' 3' encoded on plus strand of chromosome 22 from 37,309,669 to 37,336,494 44449 42804 75267 54249 44378 7518 71660 74375 33370 37182 53530 33679 a 49713 44449 42804 75267 54249 44378 27155 71660 74375 33370 37182 53530 33679 b [NM] 37 75267 54249 44378 7518 71660 74375 33370 37182 53530 33679 c 21 42804 75267 54249 44378 d e-u 1 2kb 0 149 bp exon 149 bp exon 51 bp uORF 149 bp exon 149 bp exon 960 bp [gt-ag] intron 30 GenBank accessions 44419 RNA-seq supporting reads 272 UHR pooled cells 59 Brain 39518 Blood 4532 Neuroblastoma 38 Other (also 2089 Primates bodymap) 124 bp exon 124 bp exon 2619 bp [gt-ag] intron 14 GenBank accessions 42790 RNA-seq supporting reads 224 UHR pooled cells 105 Brain 37621 Blood 4796 Neuroblastoma 44 Other (also 1081 Primates bodymap) 191 bp exon 191 bp exon 3224 bp [gt-ag] intron 14 GenBank accessions 75253 RNA-seq supporting reads 385 UHR pooled cells 103 Brain 68566 Blood 6145 Neuroblastoma 54 Other (also 2713 Primates bodymap) 158 bp exon 158 bp exon 79 bp [gt-ag] intron 14 GenBank accessions 54235 RNA-seq supporting reads 354 UHR pooled cells 85 Brain 48253 Blood 5507 Neuroblastoma 36 Other (also 1872 Primates bodymap) 169 bp exon 169 bp exon 567 bp [gt-ag] intron 14 GenBank accessions 44364 RNA-seq supporting reads 305 UHR pooled cells 87 Brain 39008 Blood 4944 Neuroblastoma 20 Other (also 1789 Primates bodymap) 136 bp exon 136 bp exon 144 bp [gt-ag] intron 5 GenBank accessions 7513 RNA-seq supporting reads 74 UHR pooled cells 30 Brain 6363 Blood 1032 Neuroblastoma 14 Other (also 37 Primates bodymap) 176 bp exon 176 bp exon 1934 bp [gt-ag] intron 9 GenBank accessions 71651 RNA-seq supporting reads 547 UHR pooled cells 148 Brain 63316 Blood 7517 Neuroblastoma 123 Other (also 1866 Primates bodymap) 140 bp exon 140 bp exon 927 bp [gt-ag] intron 13 GenBank accessions 74362 RNA-seq supporting reads 500 UHR pooled cells 136 Brain 66664 Blood 6977 Neuroblastoma 85 Other (also 3913 Primates bodymap) 163 bp exon 163 bp exon 1356 bp [gt-ag] intron 12 GenBank accessions 33358 RNA-seq supporting reads 317 UHR pooled cells 95 Brain 28299 Blood 4606 Neuroblastoma 41 Other (also 1241 Primates bodymap) 91 bp exon 91 bp exon 188 bp [gt-ag] intron 12 GenBank accessions 37170 RNA-seq supporting reads 490 UHR pooled cells 133 Brain 30640 Blood 5851 Neuroblastoma 56 Other (also 2061 Primates bodymap) 58 bp exon 58 bp exon 861 bp [gt-ag] intron 12 GenBank accessions 53518 RNA-seq supporting reads 536 UHR pooled cells 125 Brain 46199 Blood 6615 Neuroblastoma 43 Other (also 1952 Primates bodymap) 104 bp exon 104 bp exon 724 bp [gt-ag] intron 9 GenBank accessions 33670 RNA-seq supporting reads 298 UHR pooled cells 78 Brain 28848 Blood 4401 Neuroblastoma 45 Other (also 1623 Primates bodymap) 1235 bp exon 1235 bp exon 4 accessions, some from placenta cot 25-normalized (seen once) 1235 bp exon 51 bp exon 8358 bp [gt-ag] intron 19 GenBank accessions 49694 RNA-seq supporting reads 78 UHR pooled cells 27 Brain 47717 Blood 1855 Neuroblastoma 17 Other (also 920 Primates bodymap) 248 bp exon 248 bp exon 960 bp [gt-ag] intron 30 GenBank accessions 44419 RNA-seq supporting reads 272 UHR pooled cells 59 Brain 39518 Blood 4532 Neuroblastoma 38 Other (also 2089 Primates bodymap) 124 bp exon 2619 bp [gt-ag] intron 14 GenBank accessions 42790 RNA-seq supporting reads 224 UHR pooled cells 105 Brain 37621 Blood 4796 Neuroblastoma 44 Other (also 1081 Primates bodymap) 191 bp exon 3224 bp [gt-ag] intron 14 GenBank accessions 75253 RNA-seq supporting reads 385 UHR pooled cells 103 Brain 68566 Blood 6145 Neuroblastoma 54 Other (also 2713 Primates bodymap) 158 bp exon 79 bp [gt-ag] intron 14 GenBank accessions 54235 RNA-seq supporting reads 354 UHR pooled cells 85 Brain 48253 Blood 5507 Neuroblastoma 36 Other (also 1872 Primates bodymap) 169 bp exon 567 bp [gt-ag] intron 14 GenBank accessions 44364 RNA-seq supporting reads 305 UHR pooled cells 87 Brain 39008 Blood 4944 Neuroblastoma 20 Other (also 1789 Primates bodymap) 136 bp exon 162 bp [gt-ag] intron 8 GenBank accessions 27147 RNA-seq supporting reads 240 UHR pooled cells 64 Brain 22431 Blood 4361 Neuroblastoma 51 Other (also 1594 Primates bodymap) 158 bp exon 1934 bp [gt-ag] intron 9 GenBank accessions 71651 RNA-seq supporting reads 547 UHR pooled cells 148 Brain 63316 Blood 7517 Neuroblastoma 123 Other (also 1866 Primates bodymap) 140 bp exon 927 bp [gt-ag] intron 13 GenBank accessions 74362 RNA-seq supporting reads 500 UHR pooled cells 136 Brain 66664 Blood 6977 Neuroblastoma 85 Other (also 3913 Primates bodymap) 163 bp exon 1356 bp [gt-ag] intron 12 GenBank accessions 33358 RNA-seq supporting reads 317 UHR pooled cells 95 Brain 28299 Blood 4606 Neuroblastoma 41 Other (also 1241 Primates bodymap) 91 bp exon 188 bp [gt-ag] intron 12 GenBank accessions 37170 RNA-seq supporting reads 490 UHR pooled cells 133 Brain 30640 Blood 5851 Neuroblastoma 56 Other (also 2061 Primates bodymap) 58 bp exon 861 bp [gt-ag] intron 12 GenBank accessions 53518 RNA-seq supporting reads 536 UHR pooled cells 125 Brain 46199 Blood 6615 Neuroblastoma 43 Other (also 1952 Primates bodymap) 104 bp exon 724 bp [gt-ag] intron 9 GenBank accessions 33670 RNA-seq supporting reads 298 UHR pooled cells 78 Brain 28848 Blood 4401 Neuroblastoma 45 Other (also 1623 Primates bodymap) 3076 bp exon 129 accessions, NM_000395.2 some from placenta (seen 15 times) placenta normal (9), germinal center B cell (4) leukopheresis (4), lymph (4) Validated 3' end, 2 accessions Validated 3' end, 10 accessions Validated 3' end, 4 accessions 3076 bp exon 61 bp exon 61 bp exon 2169 bp [gt-ag] intron 2 GenBank accessions 35 RNA-seq supporting reads 1 UHR pooled cells 33 Blood 1 Neuroblastoma 191 bp exon 3224 bp [gt-ag] intron 14 GenBank accessions 75253 RNA-seq supporting reads 385 UHR pooled cells 103 Brain 68566 Blood 6145 Neuroblastoma 54 Other (also 2713 Primates bodymap) 158 bp exon 79 bp [gt-ag] intron 14 GenBank accessions 54235 RNA-seq supporting reads 354 UHR pooled cells 85 Brain 48253 Blood 5507 Neuroblastoma 36 Other (also 1872 Primates bodymap) 169 bp exon 567 bp [gt-ag] intron 14 GenBank accessions 44364 RNA-seq supporting reads 305 UHR pooled cells 87 Brain 39008 Blood 4944 Neuroblastoma 20 Other (also 1789 Primates bodymap) 136 bp exon 144 bp [gt-ag] intron 5 GenBank accessions 7513 RNA-seq supporting reads 74 UHR pooled cells 30 Brain 6363 Blood 1032 Neuroblastoma 14 Other (also 37 Primates bodymap) 176 bp exon 1934 bp [gt-ag] intron 9 GenBank accessions 71651 RNA-seq supporting reads 547 UHR pooled cells 148 Brain 63316 Blood 7517 Neuroblastoma 123 Other (also 1866 Primates bodymap) 140 bp exon 927 bp [gt-ag] intron 13 GenBank accessions 74362 RNA-seq supporting reads 500 UHR pooled cells 136 Brain 66664 Blood 6977 Neuroblastoma 85 Other (also 3913 Primates bodymap) 163 bp exon 1356 bp [gt-ag] intron 12 GenBank accessions 33358 RNA-seq supporting reads 317 UHR pooled cells 95 Brain 28299 Blood 4606 Neuroblastoma 41 Other (also 1241 Primates bodymap) 91 bp exon 188 bp [gt-ag] intron 12 GenBank accessions 37170 RNA-seq supporting reads 490 UHR pooled cells 133 Brain 30640 Blood 5851 Neuroblastoma 56 Other (also 2061 Primates bodymap) 58 bp exon 861 bp [gt-ag] intron 12 GenBank accessions 53518 RNA-seq supporting reads 536 UHR pooled cells 125 Brain 46199 Blood 6615 Neuroblastoma 43 Other (also 1952 Primates bodymap) 104 bp exon 724 bp [gt-ag] intron 9 GenBank accessions 33670 RNA-seq supporting reads 298 UHR pooled cells 78 Brain 28848 Blood 4401 Neuroblastoma 45 Other (also 1623 Primates bodymap) 1318 bp exon 2 accessions, some from testis (seen 2 times) 1318 bp exon 119 bp exon 513 bp [gt-ag] intron 1 GenBank accession 20 RNA-seq supporting reads 8 Blood 12 Neuroblastoma (also 6 Primates bodymap) 124 bp exon 2619 bp [gt-ag] intron 14 GenBank accessions 42790 RNA-seq supporting reads 224 UHR pooled cells 105 Brain 37621 Blood 4796 Neuroblastoma 44 Other (also 1081 Primates bodymap) 191 bp exon 191 bp exon 3224 bp [gt-ag] intron 14 GenBank accessions 75253 RNA-seq supporting reads 385 UHR pooled cells 103 Brain 68566 Blood 6145 Neuroblastoma 54 Other (also 2713 Primates bodymap) 158 bp exon 79 bp [gt-ag] intron 14 GenBank accessions 54235 RNA-seq supporting reads 354 UHR pooled cells 85 Brain 48253 Blood 5507 Neuroblastoma 36 Other (also 1872 Primates bodymap) 169 bp exon 567 bp [gt-ag] intron 14 GenBank accessions 44364 RNA-seq supporting reads 305 UHR pooled cells 87 Brain 39008 Blood 4944 Neuroblastoma 20 Other (also 1789 Primates bodymap) 132 bp exon 1 accession from placenta cot 25-normalized 132 bp exon 211 bp exon 1 accession from placenta normal 211 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA		 Downstream sequence
aAug10 2894 bp 903 aa 73 bp 109 bp 48 bp 2kb possibly including promoter 16477 bp 1kb
bAug10 4867 bp 897 aa 223 bp 1950 bp 2kb possibly including promoter 26826 bp 1kb
cAug10 2765 bp 844 aa 38 bp 192 bp 2kb possibly including promoter 14938 bp 1kb
dAug10 893 bp 203 aa 283 bp 2kb possibly including promoter 7895 bp 1kb
eAug10-unspliced 211 bp 36 aa 103 bp 2kb 211 bp 1kb

Gene neighbors and Navigator on chromosome 22q13.1 back to top
R R C NCF4 D C I R P CSF2RB D C I R P C R MPST D C I R P C KCTD17 C I R P R CYTH4 C I R P C R C R P C I R P EIF3D D C I P CACNG2 C C I R P IFT27 D C R P PVALB R P FLJ90680 P C C R P C22orf33 D C I R P TST R D C I R P TMPRSS6 D C I R P C1QTNF6andIL2RB D C I R P SSTR3 D C I R P RAC2 C R P ELFN2 100kb 0 jotey, 20 accessions, 4 variants jeetey, 7 accessions, 5 variants sparvaw, 8 accessions NCF4, 164 accessions, 7 variants CSF2RB, 139 accessions 5 variants smerdoy, 1 accession MPST, 408 accessions, 11 variants kertey, 1 accession KCTD17, 141 accessions 12 variants rasi, 5 accessions, 2 variants CYTH4, 242 accessions 14 variants ranira, 1 accession gleejaw, 6 accessions gerro, 1 accession kleezer, 1 accession korro, 1 accession koyro, 2 accessions jartey, 2 accessions loro, 1 accession nawro, 1 accession neero, 1 accession zufor, 2 accessions nerro, 1 accession norro, 1 accession borkor, 1 accession puro, 1 accession zofor, 3 accessions perro, 2 accessions ryro, 1 accession royro, 1 accession kleesubo, 1 accession seyro, 1 accession klerfaw, 1 accession sisa, 2 accessions darkor, 1 accession dawkor, 1 accession varo, 1 accession voro, 1 accession ployfaw, 2 accessions fokor, 1 accession wyro, 1 accession wuro, 1 accession geekor, 1 accession leezey, 1 accession zaro, 1 accession meezey, 1 accession zeero, 1 accession nami, 3 accessions zoyro, 1 accession charo, 1 accession churo, 2 accessions choro, 1 accession jukor, 1 accession chorzey, 1 accession shoro, 1 accession bluro, 1 accession slawfaw, 1 accession shuzey, 1 accession blorro, 1 accession shawfor, 1 accession floro, 2 accessions sheefor, 1 accession glawro, 1 accession jawkor, 1 accession klarsubo, 1 accession fleyjaw, 3 accessions juro, 1 accession bakor, 1 accession jawro, 1 accession jeero, 2 accessions jorro, 1 accession kyro, 1 accession kerro, 2 accessions bykor, 1 accession beekor, 1 accession flozer, 4 accessions serara, 1 accession nerpa, 3 accessions laro, 1 accession slyzer, 1 accession spyvaw, 25 accessions loyro, 1 accession myro, 1 accession klawsubo, 2 accessions spuvaw, 2 accessions meero, 1 accession zafor, 1 accession ramiru, 2 accessions smorzer, 1 accession narro, 1 accession noyro, 1 accession jertey, 2 accessions poyro, 1 accession sawro, 1 accession klorfaw, 1 accession teero, 1 accession pleefaw, 1 accession torro, 1 accession zawfor, 2 accessions pleyfaw, 1 accession vorro, 2 accessions farkor, 1 accession dyzey, 1 accession zeefor, 2 accessions kotey, 3 accessions, 2 variants gukor, 1 accession woro, 1 accession wawro, 1 accession weero, 1 accession woyro, 1 accession zyro, 1 accession skofaw, 7 accessions goykor, 1 accession zarro, 1 accession zawro, 1 accession zerro, 3 accessions zorro, 1 accession chyro, 1 accession jakor, 1 accession cheyfor, 1 accession warzey, 2 accessions spervaw, 12 accessions choyro, 2 accessions warira, 1 accession shuro, 1 accession blaro, 1 accession bleero, 2 accessions bleyro, 1 accession flyro, 1 accession blazey, 1 accession lotey, 1 accession fleero, 1 accession lawtey, 17 accessions spoyvaw, 0 accession klersubo, 1 accession gleezey, 1 accession munira, 2 accessions, 2 variants glerro, 1 accession FOXRED2andTXN2, 585 accessions 22 variants EIF3D, 501 accessions 19 variants CACNG2, 50 accessions 2 variants dukor, 1 accession IFT27, 212 accessions 17 variants PVALB, 134 accessions 6 variants FLJ90680, 18 accessions 3 variants sorara, 2 accessions luzey, 1 accession C22orf33, 26 accessions 4 variants TST, 262 accessions, 4 variants keetey, 1 accession TMPRSS6, 41 accessions 6 variants C1QTNF6andIL2RB, 383 accessions 27 variants SSTR3, 24 accessions, 2 variants RAC2, 436 accessions, 7 variants ELFN2, 45 accessions, 8 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               71 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !