Homo sapiens gene APH1B, encoding anterior pharynx defective 1 homolog B (C. elegans).
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SUMMARY back to top
RefSeq summary
[APH1B] APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM].

RefSeq annotates 2 representative transcripts (NM included in AceView variants .b and .d), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 9 spliced variants.

AceView synopsis, each blue text links to tables and details
Expression: According to AceView, this gene is expressed at high level, 2.6 times the average gene in this release. The sequence of this gene is defined by 307 GenBank accessions from 270 cDNA clones, some from testis (seen 46 times), brain (28), lung (20), eye (11), hippocampus (11), carcinoid (9), kidney (9) and 71 other tissues. We annotate structural defects or features in 7 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 13 distinct gt-ag introns. Transcription produces 10 different mRNAs, 9 alternatively spliced variants and 1 unspliced form. There are 3 probable alternative promotors, 2 non overlapping alternative last exons and 10 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 4 cassette exons, overlapping exons with different boundaries.
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant eAug10).
Function: There are 19 articles specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in processes (apoptosis, induction of apoptosis by extracellular signals, membrane protein intracellular domain proteolysis, protein processing, Notch signaling pathway, positive regulation of catalytic activity). Proteins are expected to have molecular functions (peptidase activity, protein binding) and to localize in various compartments (integral to membrane, plasma membrane, transport vesicle). Putative protein interactors have been described (NCSTN, PSEN1, PSEN2).
Protein coding potential: 7 spliced mRNAs putatively encode good proteins, altogether 6 different isoforms (3 complete, 3 partial), some containing Aph-1 protein domain [Pfam], some transmembrane domains [Psort2]. The remaining 3 mRNA variants (2 spliced, 1 unspliced) appear not to encode good proteins.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 15, links to other databases and other names
Map: This gene APH1B maps on chromosome 15, at 15q22.2 according to Entrez Gene. In AceView, it covers 33.11 kb, from 63568217 to 63601330 (NCBI 37, August 2010), on the direct strand.
Links to: the SNP view, gene overviews from Entrez Gene 83464, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as APH1B, UNQ688/PRO1328, PSFL, APH-1b, PRO1328, TAAV688, FLJ33115 or DKFZp564D0372, LOC83464. It has been described as gamma-secretase subunit APH-1B, aph-1beta, anterior pharynx defective 1B-like, presenilin stabilization factor-like, presenilin-stabilization factor-like.
Closest AceView homologs in other species ?
The closest mouse genes, according to BlastP, are the AceView genes Aph1b (e=7 10-90), Aph1c (e=2 10-85).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene aph-1 (e=10-09), which may contain interesting functional annotation.
The closest A.thaliana gene, according to BlastP, is the AceView gene AT2G31440 (e=10-06), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
APH1B Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 2.05 11.6 5.40 0.55 7.13 1.91 8.78 13.3 17.6 7.64 12.4 15.3 4.39 7.64 10.8 3.10 6.21 10.8 3.33 16.4 53.2 18.8 8.78 4.10 0.72 0.63 0.96 0.59 1.26 10.8 15.3 13.3 7.13 17.6 14.3 17.6 7.13 5.04 4.71 6.65 11.6 6.65 4.10 5.40 10.1 3.82 13.3 16.4 6.65 2.90 1.66 1.10 2.70 3.33 0.89 0.36 3.10 1.35 3.10 10.1 5.40 2.90 7.64 5.04 3.82 5.79 10.8 13.3 14.3 10.1 10.8 7.64 4.10 7.64 16.4 12.4 3.10 9.41 5.04 10.1 11.6 4.71 4.39 15.3 15.3 12.4 3.82 9.41 16.4 10.1 12.4 4.39 5.40 9.41 3.82 8.19 10.8 3.10 14.3 5.04 2.35 3.57 3.82 2.05 0.63 6.21 8.19 4.39 2.90 4.10 2.90 9.41 10.8 13.3 14.3 4.71 2.70 10.1 18.8 4.39 12.4 5.40 6.21 10.8 2.19 9.41 2.90 2.90 13.3 2.90 6.65 11.6 8.78 7.64 10.1 4.10 4.39 1.26 1.10 0.42 9.41 6.21 10.8 4.71 9.41 3.82 18.8 6.21 8.19 30.6 2.05 10.1 6.21 10.1 7.13 4.39 7.64 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene APH1B 5' 3' encoded on plus strand of chromosome 15 from 63,568,217 to 63,601,330 2 18358 13557 20906 16632 a 21604 18358 13557 20906 16632 b [NM] 21604 18358 13557 22 c 21604 18358 1412 16632 d [NM] 6 j 75 18358 13557 20906 16632 e 299 326 18358 13557 20906 16632 f 20906 g h-u 10 16632 i 1 2kb 0 143 bp exon 3000 bp [gt-ag] intron 2 GenBank accessions 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 795 bp [gt-ag] intron 120 GenBank accessions 13437 RNA-seq supporting reads 991 UHR pooled cells 1990 Brain 3763 Blood 6604 Neuroblastoma 89 Other (also 3021 Primates bodymap) 123 bp exon 14798 bp [gt-ag] intron 118 GenBank accessions 20788 RNA-seq supporting reads 1668 UHR pooled cells 3111 Brain 4633 Blood 11231 Neuroblastoma 145 Other (also 6575 Primates bodymap) 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 163 bp exon 2 accessions 163 bp exon 217 bp exon 217 bp exon 1424 bp [gt-ag] intron 108 GenBank accessions 21496 RNA-seq supporting reads 1612 UHR pooled cells 2668 Brain 6202 Blood 10908 Neuroblastoma 106 Other (also 4986 Primates bodymap) 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 795 bp [gt-ag] intron 120 GenBank accessions 13437 RNA-seq supporting reads 991 UHR pooled cells 1990 Brain 3763 Blood 6604 Neuroblastoma 89 Other (also 3021 Primates bodymap) 123 bp exon 14798 bp [gt-ag] intron 118 GenBank accessions 20788 RNA-seq supporting reads 1668 UHR pooled cells 3111 Brain 4633 Blood 11231 Neuroblastoma 145 Other (also 6575 Primates bodymap) 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 3512 bp exon 126 accessions, NM_031301.3 some from testis (seen 34 times) brain (21), hippocampus (10) cerebellum (5), medulla (5) capped 5' end, 54 accessions Validated 3' end, 1 accession Validated 3' end, 9 accessions Validated 3' end, 1 accession 3512 bp exon 119 bp exon 119 bp exon 1424 bp [gt-ag] intron 108 GenBank accessions 21496 RNA-seq supporting reads 1612 UHR pooled cells 2668 Brain 6202 Blood 10908 Neuroblastoma 106 Other (also 4986 Primates bodymap) 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 795 bp [gt-ag] intron 120 GenBank accessions 13437 RNA-seq supporting reads 991 UHR pooled cells 1990 Brain 3763 Blood 6604 Neuroblastoma 89 Other (also 3021 Primates bodymap) 123 bp exon 18067 bp [gt-ag] intron 1 GenBank accession 21 RNA-seq supporting reads 3 UHR pooled cells 6 Brain 2 Blood 9 Neuroblastoma 1 Other (also 66 Primates bodymap) 1 accession from embryonal carcinoma cell line from testis 203 bp exon 186 bp exon 186 bp exon 1424 bp [gt-ag] intron 108 GenBank accessions 21496 RNA-seq supporting reads 1612 UHR pooled cells 2668 Brain 6202 Blood 10908 Neuroblastoma 106 Other (also 4986 Primates bodymap) 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 15716 bp [gt-ag] intron 8 GenBank accessions 1404 RNA-seq supporting reads 134 UHR pooled cells 34 Brain 840 Blood 393 Neuroblastoma 3 Other (also 33 Primates bodymap) 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 3512 bp exon 66 accessions, NM_001145646.1 some from eye (seen 8 times) testis (8), brain (4) trachea (4), retinoblastoma (3) Validated 3' end, 3 accessions Validated 3' end, 2 accessions Validated 3' end, 1 accession Validated 3' end, 1 accession Validated 3' end, 4 accessions 3512 bp exon 245 bp exon 245 bp exon 363 bp [gt-ag] intron 3 GenBank accessions 3 RNA-seq supporting reads 1 Blood 2 Neuroblastoma (also 116 Primates bodymap) 227 bp exon 3 accessions 227 bp exon 249 bp exon 249 bp exon 177 bp uORF 249 bp exon 1231 bp [gt-ag] intron 2 GenBank accessions 73 RNA-seq supporting reads 12 UHR pooled cells 7 Brain 13 Blood 41 Neuroblastoma (also 3 Primates bodymap) 171 bp exon 171 bp exon 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 71 bp exon 795 bp [gt-ag] intron 120 GenBank accessions 13437 RNA-seq supporting reads 991 UHR pooled cells 1990 Brain 3763 Blood 6604 Neuroblastoma 89 Other (also 3021 Primates bodymap) 123 bp exon 123 bp exon 14798 bp [gt-ag] intron 118 GenBank accessions 20788 RNA-seq supporting reads 1668 UHR pooled cells 3111 Brain 4633 Blood 11231 Neuroblastoma 145 Other (also 6575 Primates bodymap) 128 bp exon 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 713 bp exon 713 bp exon 2 accessions, some from uterus (seen 2 times) capped 5' end, 1 accession 713 bp exon 127 bp exon 554 bp [gt-ag] intron 1 GenBank accession 298 RNA-seq supporting reads 29 UHR pooled cells 58 Brain 58 Blood 150 Neuroblastoma 3 Other (also 6 Primates bodymap) 64 bp exon 806 bp [gt-ag] intron 1 GenBank accession 325 RNA-seq supporting reads 25 UHR pooled cells 65 Brain 40 Blood 192 Neuroblastoma 3 Other (also 6 Primates bodymap) 171 bp exon 171 bp exon 7226 bp [gt-ag] intron 123 GenBank accessions 18235 RNA-seq supporting reads 1573 UHR pooled cells 2586 Brain 4560 Blood 9384 Neuroblastoma 132 Other (also 4488 Primates bodymap) 71 bp exon 795 bp [gt-ag] intron 120 GenBank accessions 13437 RNA-seq supporting reads 991 UHR pooled cells 1990 Brain 3763 Blood 6604 Neuroblastoma 89 Other (also 3021 Primates bodymap) 123 bp exon 14798 bp [gt-ag] intron 118 GenBank accessions 20788 RNA-seq supporting reads 1668 UHR pooled cells 3111 Brain 4633 Blood 11231 Neuroblastoma 145 Other (also 6575 Primates bodymap) 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 188 bp exon 1 accession from testis 188 bp exon 366 bp exon 366 bp exon 14798 bp [gt-ag] intron 118 GenBank accessions 20788 RNA-seq supporting reads 1668 UHR pooled cells 3111 Brain 4633 Blood 11231 Neuroblastoma 145 Other (also 6575 Primates bodymap) 1 accession from head neck 149 bp exon 1993 bp exon 1993 bp exon 1993 bp exon Sequence gap 1384 bp 74 accessions, some from lung (seen 15 times) carcinoid (7), liver and spleen (7) kidney (6), breast carcinoma (3) capped 5' end, 4 accessions Validated 3' end, 13 accessions 1435 bp exon 312 bp exon 10347 bp [gt-ag] intron 2 GenBank accessions 8 RNA-seq supporting reads 1 Brain 3 Blood 4 Neuroblastoma (also 1 Primates bodymap) 128 bp exon 128 bp exon 3141 bp [gt-ag] intron 84 GenBank accessions 16548 RNA-seq supporting reads 1348 UHR pooled cells 2271 Brain 4408 Blood 8398 Neuroblastoma 123 Other (also 3927 Primates bodymap) 291 bp exon 2 accessions, some from brain (seen once) medulla (once) Validated 3' end, 2 accessions 291 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 799 bp 266 aa 2kb 29759 bp 1kb
bAug10 4222 bp 257 aa 104 bp 3344 bp 2kb including Promoter 31606 bp 1kb
cAug10 687 bp 227 aa 6 bp 2kb probably including promoter 28199 bp 1kb
dAug10 4068 bp 216 aa 73 bp 3344 bp 2kb probably including promoter 31575 bp 1kb
eAug10 1455 bp 203 aa 298 bp 545 bp 174 bp 2kb including Promoter 28646 bp 1kb
fAug10 872 bp 203 aa 240 bp 20 bp 2kb probably including promoter 28192 bp 1kb
gAug10 515 bp 83 aa 266 bp 2kb possibly including promoter 15313 bp 1kb
hAug10-unspliced 4469 bp 97 aa 1212 bp 2963 bp 2kb including Promoter 4812 bp 1kb
iAug10 731 bp 96 aa 317 bp 123 bp 2kb 14219 bp 1kb
jAug10 472 bp 34 aa 235 bp 132 bp 2kb 835 bp 1kb

Gene neighbors and Navigator on chromosome 15q22.2 back to top
TPM1 D C I R P R LACTB C R P R R RAB8B C I R P APH1B C I R P C R USP3 C I R P FBXL22 C R P C R R C G R C R P RPS27L D C I R P CA12 G R C I R P HERC1 100kb 0 TLN2, 277 accessions, 11 variants TPM1, 1131 accessions 44 variants skerpee, 4 accessions 2 variants LACTB, 119 accessions 7 variants jostaw, 9 accessions jerstaw, 6 accessions RAB8B, 350 accessions 9 variants APH1B, 285 accessions 10 variants meystaw, 3 accessions slopee, 4 accessions, 2 variants USP3, 486 accessions, 28 variants FBXL22, 45 accessions 7 variants teyzeybu, 1 accession ferstaw, 1 accession forstaw, 1 accession skarpee, 4 accessions kawsey, 1 accession garstaw, 25 accessions geystaw, 2 accessions gorstaw, 1 accession goystaw, 1 accession jastaw, 1 accession justaw, 1 accession mukoma, 2 accessions, 2 variants leydee, 4 accessions rugeeby, 1 accession pyzeybu, 1 accession jorstaw, 1 accession joystaw, 1 accession pozeybu, 1 accession tozee, 2 accessions tarzee, 2 accessions kostaw, 3 accessions woygeeby, 1 accession parzeybu, 9 accessions skerspee, 2 accessions tawzee, 2 accessions lerstaw, 2 accessions zorsorbo, 1 accession lorstaw, 1 accession mastaw, 1 accession mystaw, 2 accessions mustaw, 2 accessions mostaw, 1 accession mawstaw, 1 accession rusey, 1 accession morstaw, 2 accessions razeybu, 1 accession mekoma, 1 accession mokoma, 3 accessions, 2 variants ruzeybu, 1 accession shogeeby, 1 accession nawstaw, 2 accessions noystaw, 1 accession reysey, 1 accession sysey, 1 accession postaw, 2 accessions parstaw, 1 accession rozeybu, 1 accession rarzeybu, 1 accession pawstaw, 2 accessions porstaw, 1 accession rystaw, 1 accession rostaw, 8 accessions vorsey, 1 accession hakoma, 3 accessions snugeeby, 1 accession reestaw, 1 accession snogeeby, 1 accession stogeeby, 1 accession royzeybu, 4 accessions sazeybu, 2 accessions vazee, 3 accessions bugerby, 1 accession sostaw, 1 accession suyu, 7 accessions dergerby, 1 accession sarstaw, 2 accessions seestaw, 1 accession seystaw, 1 accession tastaw, 1 accession tarstaw, 5 accessions sperzobu, 3 accessions hikoma, 1 accession sawzeybu, 1 accession sorzeybu, 1 accession vystaw, 1 accession gygerby, 1 accession voysey, 1 accession vawstaw, 5 accessions veestaw, 1 accession veystaw, 2 accessions tawzeybu, 1 accession wosey, 1 accession wostaw, 1 accession warstaw, 1 accession weestaw, 1 accession zastaw, 1 accession terzeybu, 1 accession vazeybu, 1 accession zasey, 1 accession merdee, 3 accessions varzeybu, 1 accession shasey, 1 accession feestaw, 1 accession kusey, 1 accession mikoma, 1 accession chyzo, 16 accessions foystaw, 3 accessions gastaw, 1 accession marsey, 2 accessions gystaw, 1 accession moysey, 1 accession nygeeby, 1 accession norgeeby, 2 accessions nusey, 2 accessions pageeby, 1 accession memiru, 1 accession jystaw, 1 accession jarstaw, 2 accessions jeystaw, 2 accessions puzeybu, 1 accession kastaw, 2 accessions kystaw, 1 accession kustaw, 1 accession karstaw, 1 accession veygeeby, 1 accession zageeby, 1 accession keystaw, 2 accessions korstaw, 1 accession zogeeby, 1 accession zeysorbo, 1 accession lastaw, 1 accession lystaw, 3 accessions lustaw, 2 accessions lostaw, 1 accession larstaw, 1 accession lawstaw, 1 accession leestaw, 2 accessions loystaw, 1 accession zawgeeby, 1 accession marstaw, 1 accession meestaw, 1 accession teezee, 1 accession peesey, 1 accession nastaw, 1 accession chasorbo, 2 accessions slypee, 2 accessions narstaw, 2 accessions neestaw, 1 accession nerstaw, 2 accessions blugeeby, 1 accession yanari, 8 accessions flergeeby, 1 accession terzee, 2 accessions tikiru, 6 accessions pastaw, 1 accession pystaw, 3 accessions pustaw, 1 accession madee, 3 accessions perstaw, 1 accession peystaw, 1 accession kleygeeby, 2 accessions plergeeby, 1 accession sarsey, 1 accession rawzeybu, 2 accessions skargeeby, 1 accession poystaw, 1 accession reezeybu, 1 accession teyzee, 1 accession veysey, 1 accession slarpee, 11 accessions rustaw, 2 accessions slawpee, 9 accessions skeegeeby, 2 accessions skoygeeby, 2 accessions rarstaw, 1 accession slawgeeby, 1 accession chysorbo, 1 accession rerstaw, 1 accession reystaw, 1 accession roystaw, 1 accession ruklor, 3 accessions stergeeby, 1 accession sustaw, 2 accessions dagerby, 1 accession sawstaw, 1 accession chusorbo, 1 accession serstaw, 1 accession mydee, 1 accession sorstaw, 2 accessions vuzee, 2 accessions tystaw, 1 accession tostaw, 1 accession suzeybu, 2 accessions sarzeybu, 1 accession seezeybu, 7 accessions teestaw, 1 accession torstaw, 1 accession toystaw, 1 accession tyzeybu, 1 accession vustaw, 1 accession vostaw, 1 accession gargerby, 1 accession jargerby, 1 accession verstaw, 1 accession vorstaw, 1 accession tuzeybu, 1 accession tozeybu, 4 accessions tarzeybu, 1 accession momiru, 1 accession wastaw, 1 accession mardee, 1 accession wustaw, 1 accession woysey, 1 accession werstaw, 1 accession weystaw, 1 accession worstaw, 1 accession teezeybu, 1 accession torzeybu, 1 accession toyzeybu, 2 accessions zustaw, 2 accessions vuzeybu, 1 accession zarstaw, 1 accession vozeybu, 1 accession zeesey, 1 accession zeestaw, 2 accessions skeespee, 5 accessions 2 variants snakley, 5 accessions 2 variants mimiru, 1 accession LOC100128979, 7 accessions 2 variants RPS27L, 564 accessions 7 variants CA12, 410 accessions, 5 variants LOC100130855, 67 accessions 10 variants HERC1, 436 accessions 36 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               19 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e, .f, .g, .h-u, .i, .j Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes CI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !