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HomoloGene:239. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PEPD,  H.sapiens
peptidase D
    NP_000276.2
493 aa
   PEPD,  P.troglodytes
peptidase D
    XP_512574.3
280 aa
   PEPD,  M.mulatta
peptidase D
    XP_001108725.2
224 aa
   PEPD,  C.lupus
peptidase D
    XP_533702.2
493 aa
   PEPD,  B.taurus
peptidase D
    NP_001073787.2
493 aa
   Pepd,  M.musculus
peptidase D
    NP_032846.2
493 aa
   Pepd,  R.norvegicus
peptidase D
    NP_001009641.1
492 aa
   PEPD,  G.gallus
peptidase D
    NP_001073185.1
497 aa
   pepd,  X.tropicalis
peptidase D
    NP_001008094.1
498 aa
   pepd,  D.rerio
peptidase D
    NP_944594.1
496 aa
   Dip-C,  D.melanogaster
Dipeptidase C
    NP_650192.1
491 aa
   AgaP_AGAP004775,  A.gambiae
AgaP_AGAP004775
    XP_318039.3
479 aa
   K12C11.1,  C.elegans
K12C11.1
    NP_490843.1
498 aa
   AT4G29490,  A.thaliana
AT4G29490
    NP_194678.2
486 aa
   Os02g0224400,  O.sativa
Os02g0224400
    NP_001046335.1
506 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for dipeptidase C (DIP-C), for which no genetic variants are known but which differs in electrophoretic mobility from dipeptidase-C in D.simulans. Specific for dipeptides with carboxy proline (Laurie-Ahlberg, 1982).

H.sapiens
Prolidase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

The decrease in prolidase activity in myeloproliferative neoplasms.
Nowicka J, et al. Adv Clin Exp Med 21, 767-71 (2012).
Serum prolidase activity in diabetic foot ulcers.
Eren MA, et al. Acta Diabetol 50, 423-7 (2013).
Increased prolidase activity and oxidative stress in PCOS.
Hilali N, et al. Clin Endocrinol (Oxf) 79, 105-10 (2013).
A Mn(II)-Mn(II) center in human prolidase.
Besio R, et al. Biochim Biophys Acta 1834, 197-204 (2013).
Prolidase and oxidative stress in chronic hepatitis C.
Duygu F, et al. J Clin Lab Anal 26, 232-7 (2012).
Oxidative stress and prolidase activity in women with uterine fibroids.
Vural M, et al. J Obstet Gynaecol 32, 68-72 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
APP_MetAP (cl00279)
  A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
AMP_N (cl08433)
  Aminopeptidase P, N-terminal domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pepd includes H.sapiens PEPD and R.norvegicus Pepd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (12 transcripts, 10 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Streptophyta
Eudicotyledons - eudicots (33 transcripts, 28 species)
Liliopsida - monocots (9 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (3 transcripts, 1 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (3 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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