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HomoloGene:73872. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CLCN5,  H.sapiens
chloride channel, voltage-sensitive 5
    NP_001121371.1
816 aa
   CLCN5,  P.troglodytes
chloride channel, voltage-sensitive 5
    XP_003317509.2
883 aa
   CLCN5,  M.mulatta
chloride channel, voltage-sensitive 5
    XP_001083186.2
816 aa
   CLCN5,  C.lupus
chloride channel, voltage-sensitive 5
    XP_005641410.1
816 aa
   CLCN5,  B.taurus
chloride channel 5
    XP_005228237.1
816 aa
   Clcn5,  M.musculus
chloride channel 5
    NP_001230691.1
816 aa
   Clcn5,  R.norvegicus
chloride channel, voltage-sensitive 5
    NP_058802.1
746 aa
   CLCN5,  G.gallus
chloride channel 5
    XP_004940778.1
826 aa
   clcn5,  X.tropicalis
chloride channel, voltage-sensitive 5
    NP_001039210.1
808 aa
   si:dkey-22f5.8,  D.rerio
si:dkey-22f5.8
    XP_001920783.2
811 aa
   LOC557584,  D.rerio
H(+)/Cl(-) exchange transporter 5-like
    XP_685762.2
811 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypophosphatemia, type III.
Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis.
Dent disease.
hypophosphatemic rickets, X-linked recessive.
Nephrolithiasis, type I.



Publications
Articles associated with genes and sequences of this homology group.

Glutamate 268 regulates transport probability of the anion/proton exchanger ClC-5.
Grieschat M & Alekov AK. J Biol Chem 287, 8101-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Voltage_gated_ClC (cl02915)
  CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
CBS_pair (cl15354)
  The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Clcn5 includes H.sapiens CLCN5 and R.norvegicus Clcn5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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