Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:250. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PKD1,  H.sapiens
polycystic kidney disease 1 (autosomal dominant)
    NP_001009944.2
4303 aa
   PKD1,  C.lupus
polycystic kidney disease 1 (autosomal dominant)
    NP_001006651.1
4311 aa
   PKD1,  B.taurus
polycystic kidney disease 1 (autosomal dominant)
    XP_003587846.1
4303 aa
   Pkd1,  M.musculus
polycystic kidney disease 1 homolog
    NP_038658.2
4293 aa
   Pkd1,  R.norvegicus
polycystic kidney disease 1 homolog (human)
    NP_001244281.1
4292 aa
   PKD1,  G.gallus
polycystic kidney disease 1 (autosomal dominant)
    XP_414854.4
4382 aa
   pkd1,  X.tropicalis
polycystic kidney disease 1 (autosomal dominant)
    XP_002932517.2
4353 aa
   LOC100149562,  D.rerio
polycystin-1-like
    XP_003197787.2
4097 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Polycystic kidney disease, adult type I.



Publications
Articles associated with genes and sequences of this homology group.

Novel PKD1 mutations - the effect on clinical phenotype of ADPKD patients in Lower Silesia.
Augustyniak-Bartosik H, et al. Postepy Hig Med Dosw (Online) 67, 157-63 (2013).
Type of PKD1 mutation influences renal outcome in ADPKD.
Cornec-Le Gall E, et al. J Am Soc Nephrol 24, 1006-13 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
PKD (pfam00801)
  PKD domain.
GPS (pfam01825)
  Latrophilin/CL-1-like GPS domain.
REJ (pfam02010)
  REJ domain.
PKD_channel (pfam08016)
  Polycystin cation channel.
COG4886 (COG4886)
  Leucine-rich repeat (LRR) protein [Function unknown].
PLAT (cl00011)
  PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
LRRNT (cl02423)
  Leucine rich repeat N-terminal domain.
WSC (cl02568)
  WSC domain.
PKD_channel (pfam08016)
  Polycystin cation channel.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
PLAT (cl00011)
  PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
GPS (cl02559)
  Latrophilin/CL-1-like GPS domain.
WSC (cl02568)
  WSC domain.
PKD (cl17457)
  polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pkd1 includes H.sapiens PKD1 and R.norvegicus Pkd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 9 species)

 

 

 

Write to the Help Desk