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HomoloGene:1693. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KCNMA1,  H.sapiens
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_001154824.1
1236 aa
   KCNMA1,  P.troglodytes
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    XP_003312698.2
1128 aa
   KCNMA1,  C.lupus
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_001003300.1
1156 aa
   KCNMA1,  B.taurus
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_777105.1
1166 aa
   Kcnma1,  M.musculus
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_001240293.1
1236 aa
   Kcnma1,  R.norvegicus
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_114016.1
1243 aa
   KCNMA1,  G.gallus
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    NP_989555.1
1137 aa
   kcnma1,  X.tropicalis
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    XP_004916071.1
1330 aa
   kcnma1a,  D.rerio
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
    NP_001139072.1
1184 aa
   slo,  D.melanogaster
slowpoke
    NP_001014652.1
1164 aa
   AgaP_AGAP003709,  A.gambiae
AgaP_AGAP003709
    XP_003436577.1
1154 aa
   slo-1,  C.elegans
slo-1
    NP_001024259.1
1140 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Isolated in screen for third chromosomal temperature-sensitive paralytic mutants (Elkins, Ganetzky and Wu, 1986); this one is uncoordinated and unable to climb when exposed to 38oC but not completely paralyzed; four-minute exposure to that high temperature causes several minutes of motionlessness on return to 22oC. Legs shake when under ether anesthesia, as in Shaker mutants but less extreme. Unconditionally defective in behavior (e.g., diminished flight ability; tends to walk or fly in anomalous short hops when in large open container). (See FlyBase for complete description.)

H.sapiens
Generalized epilepsy and paroxysmal dyskinesia.



Publications
Articles associated with genes and sequences of this homology group.

Properties of Slo1 K+ channels with and without the gating ring.
Budelli G, et al. Proc Natl Acad Sci U S A 110, 16657-62 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BK_channel_a (pfam03493)
  Calcium-activated BK potassium channel alpha subunit.
TrkA_N (pfam02254)
  TrkA-N domain.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
TrkA_N (pfam02254)
  TrkA-N domain.
BK_channel_a (pfam03493)
  Calcium-activated BK potassium channel alpha subunit.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnma1 includes H.sapiens KCNMA1 and R.norvegicus Kcnma1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (25 transcripts, 7 species)
Mammalia - mammals (16 transcripts, 12 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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