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HomoloGene:32117. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RAD17,  H.sapiens
RAD17 homolog (S. pombe)
    NP_579917.1
681 aa
   RAD17,  P.troglodytes
RAD17 homolog (S. pombe)
    XP_003950588.1
681 aa
   RAD17,  M.mulatta
RAD17 homolog (S. pombe)
    XP_001093481.1
670 aa
   RAD17,  C.lupus
RAD17 homolog (S. pombe)
    XP_535265.2
680 aa
   RAD17,  B.taurus
RAD17 homolog (S. pombe)
    NP_001096714.1
682 aa
   Rad17,  M.musculus
RAD17 homolog (S. pombe)
    NP_001037836.1
688 aa
   Rad17,  R.norvegicus
RAD17 homolog (S. pombe)
    NP_001019949.1
686 aa
   RAD17,  G.gallus
RAD17 homolog (S. pombe)
    NP_998749.1
694 aa
   rad17,  X.tropicalis
RAD17 homolog
    XP_002934861.1
675 aa
   rad17,  D.rerio
RAD17 homolog (S. pombe)
    NP_001002661.1
665 aa
   Rad17,  D.melanogaster
Rad17
    NP_650382.3
535 aa
   AgaP_AGAP008673,  A.gambiae
AgaP_AGAP008673
    XP_314771.2
408 aa
   ATRAD17,  A.thaliana
ATRAD17
    NP_201414.1
599 aa
   Os03g0242100,  O.sativa
Os03g0242100
    NP_001049521.2
572 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The human homolog of fission yeast Rad17 is implicated in tumor growth.
Beretta GL, et al. Cancer Lett 266, 194-202 (2008).
Downregulation of RAD17 in head and neck cancer.
Zhao M, et al. Head Neck 30, 35-42 (2008).
DNA damage checkpoints in mammals.
Niida H & Nakanishi M. Mutagenesis 21, 3-9 (2006).
[Human hR24L gene is involved in DNA excision repair and recombination repair].
Han Y & Zhu Y. Zhonghua Yi Xue Za Zhi 79, 941-3 (1999).
Functional relationship between Claspin and Rad17.
Yoshimura A, et al. Biochem Biophys Res Commun 414, 298-303 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
AAA_16 (pfam13191)
  AAA ATPase domain.
AAA_17 (pfam13207)
  AAA domain.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
RecA-like_NTPases (cl17233)
  RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and ...
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
AAA_17 (cl19128)
  AAA domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rad17 includes H.sapiens RAD17 and R.norvegicus Rad17.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (4 transcripts, 4 species)
Liliopsida - monocots (3 transcripts, 3 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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