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HomoloGene:1212. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PAX6,  H.sapiens
paired box 6
    NP_001595.2
436 aa
   PAX6,  P.troglodytes
paired box 6
    XP_003954413.1
430 aa
   PAX6,  M.mulatta
paired box 6
    XP_001084865.2
470 aa
   PAX6,  B.taurus
paired box 6
    NP_001035735.1
422 aa
   Pax6,  M.musculus
paired box 6
    NP_001231127.1
436 aa
   Pax6,  R.norvegicus
paired box 6
    NP_037133.1
422 aa
   PAX6,  G.gallus
paired box 6
    NP_990397.1
436 aa
   pax6,  X.tropicalis
paired box 6
    NP_001006763.1
424 aa
   pax6a,  D.rerio
paired box gene 6a
    NP_571379.1
451 aa
   toy,  D.melanogaster
twin of eyeless
    NP_524638.3
543 aa
   AgaP_AGAP000067,  A.gambiae
AgaP_AGAP000067
    XP_311087.5
313 aa
   vab-3,  C.elegans
vab-3
    NP_001024570.1
455 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aniridia, type II.
Coloboma, ocular.
Coloboma of optic nerve.
Ectopia pupillae.
Foveal hypoplasia, isolated.
Keratitis.
Optic nerve hypoplasia/aplasia.
Peters anomaly.
Cataract, congenital, with late-onset corneal dystrophy.
Eye anomalies, multiplex.
Morning glory disc anomaly.



Publications
Articles associated with genes and sequences of this homology group.

[Identification of a novel PAX6 mutation in a family with congenital aniridia].
Li J, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 579-81 (2013).
Three cases with unusual ophthalmic phenotypes of congenital aniridia.
Lee NY, et al. Can J Ophthalmol 48, 340-2 (2013).
Association of paired box 6 with high myopia in Japanese.
Miyake M, et al. Mol Vis 18, 2726-35 (2012).
Pituitary function and glucose tolerance in a family with a PAX6 mutation.
Hergott-Faure L, et al. Ann Endocrinol (Paris) 73, 510-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
PAX (cl19075)
  Paired Box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pax6 includes H.sapiens PAX6 and R.norvegicus Pax6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (13 transcripts, 7 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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