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HomoloGene:3229. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NCAN,  H.sapiens
neurocan
    NP_004377.2
1321 aa
   NCAN,  P.troglodytes
neurocan
    NP_001029342.1
1321 aa
   NCAN,  M.mulatta
neurocan core protein-like
    XP_002808228.1
1218 aa
   NCAN,  C.lupus
neurocan
    XP_541924.3
1319 aa
   NCAN,  B.taurus
neurocan
    NP_001180011.1
1347 aa
   Ncan,  M.musculus
neurocan
    NP_031815.2
1268 aa
   LOC102550316,  R.norvegicus
neurocan core protein-like
    XP_006253042.1
1263 aa
   Ncan,  R.norvegicus
neurocan
    NP_113841.2
1263 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Neurocan contributes to the molecular heterogeneity of the perinodal ECM.
Bekku Y & Oohashi T. Arch Histol Cytol 73, 95-102 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
Link_Domain (cl02612)
  The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ncan includes H.sapiens NCAN and R.norvegicus Ncan.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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