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HomoloGene:467. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CRX,  H.sapiens
cone-rod homeobox
    NP_000545.1
299 aa
   CRX,  P.troglodytes
cone-rod homeobox
    XP_524319.3
299 aa
   CRX,  M.mulatta
cone-rod homeobox
    XP_001113415.2
356 aa
   CRX,  C.lupus
cone-rod homeobox
    NP_001003049.1
299 aa
   CRX,  B.taurus
cone-rod homeobox
    NP_776329.1
299 aa
   Crx,  M.musculus
cone-rod homeobox
    NP_001106801.1
323 aa
   Crx,  R.norvegicus
cone-rod homeobox
    NP_068627.1
299 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cone-rod retinal dystrophy-2.
Retinitis pigmentosa, late-onset dominant.
Leber congenital amaurosis VII.



Publications
Articles associated with genes and sequences of this homology group.

CRX variants in cone-rod dystrophy and mutation overview.
Huang L, et al. Biochem Biophys Res Commun 426, 498-503 (2012).
Crx broadly modulates the pineal transcriptome.
Rovsing L, et al. J Neurochem 119, 262-74 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TF_Otx (pfam03529)
  Otx1 transcription factor.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Crx includes H.sapiens CRX and R.norvegicus Crx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)

 

 

 

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