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HomoloGene:2234. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ATXN2,  H.sapiens
ataxin 2
    NP_002964.3
1313 aa
   ATXN2,  P.troglodytes
ataxin 2
    XP_509374.3
1412 aa
   LOC710742,  M.mulatta
ataxin-2-like
    XP_002808037.1
1307 aa
   ATXN2,  C.lupus
ataxin 2
    XP_850628.2
1312 aa
   ATXN2,  B.taurus
ataxin 2
    XP_005218048.1
1296 aa
   Atxn2,  M.musculus
ataxin 2
    NP_033151.2
1286 aa
   Atxn2,  R.norvegicus
ataxin 2
    XP_003751243.2
1089 aa
   ATXN2,  G.gallus
ataxin 2
    XP_004945644.1
1107 aa
   atxn2,  X.tropicalis
ataxin 2
    XP_002937742.2
1082 aa
   atxn2,  D.rerio
ataxin 2
    NP_001121821.1
1112 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spinocerebellar ataxia-2.



Publications
Articles associated with genes and sequences of this homology group.

De novo mutations in ataxin-2 gene and ALS risk.
Laffita-Mesa JM, et al. PLoS One 8, e70560 (2013).
Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.
Drost J, et al. J Mol Neurosci 51, 68-81 (2013).
Estimation of survival in spinocerebellar ataxia type 2 Cuban patients.
Almaguer-Mederos LE, et al. Clin Genet 83, 293-4 (2013).
Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.
Van Langenhove T, et al. Neurobiol Aging 33, 1004.e17-20 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
LsmAD (pfam06741)
  LsmAD domain.
SM-ATX (pfam14438)
  SM domain found in Ataxin-2.
LsmAD (pfam06741)
  LsmAD domain.
PAM2 (pfam07145)
  Ataxin-2 C-terminal region.
SM-ATX (pfam14438)
  Ataxin 2 SM domain.
Sm_like (cl00259)
  Sm and related proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atxn2 includes H.sapiens ATXN2 and R.norvegicus Atxn2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 15 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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