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HomoloGene:68295. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC22A5,  H.sapiens
solute carrier family 22 (organic cation/carnitine transporter), member 5
    NP_003051.1
557 aa
   SLC22A5,  P.troglodytes
solute carrier family 22 (organic cation/carnitine transporter), member 5
    XP_003310855.1
557 aa
   SLC22A5,  M.mulatta
solute carrier family 22 (organic cation/carnitine transporter), member 5
    XP_001103789.1
557 aa
   SLC22A5,  C.lupus
solute carrier family 22 (organic cation/carnitine transporter), member 5
    XP_860734.1
557 aa
   SLC22A5,  B.taurus
solute carrier family 22 (organic cation/carnitine transporter), member 5
    NP_001039967.1
557 aa
   Slc22a5,  M.musculus
solute carrier family 22 (organic cation transporter), member 5
    NP_035526.1
557 aa
   Slc22a5,  R.norvegicus
solute carrier family 22 (organic cation/carnitine transporter), member 5
    NP_062142.1
557 aa
   slc22a4,  X.tropicalis
solute carrier family 22 (organic cation/zwitterion transporter), member 4
    NP_989323.1
553 aa
   slc22a5,  X.tropicalis
solute carrier family 22 (organic cation/carnitine transporter), member 5
    XP_002934410.1
550 aa
   LOC101731319,  X.tropicalis
solute carrier family 22 member 5-like
    XP_004920385.1
423 aa
   slc22a4,  D.rerio
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
    NP_957143.1
553 aa
   2-Oct,  A.thaliana
2-Oct
    NP_178054.1
527 aa
   3-Oct,  A.thaliana
3-Oct
    NP_173089.1
518 aa
   Os07g0562300,  O.sativa
Os07g0562300
    NP_001059989.1
537 aa
   Os01g0330500,  O.sativa
Os01g0330500
    NP_001172311.1
691 aa
   Os07g0562400,  O.sativa
Os07g0562400
    NP_001059990.1
534 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Carnitine deficiency, systemic primary.



Publications
Articles associated with genes and sequences of this homology group.

Systemic Primary Carnitine Deficiency
El-Hattab AW, et al. (1993).
Inhibition of OCTN2-mediated transport of carnitine by etoposide.
Hu C, et al. Mol Cancer Ther 11, 921-9 (2012).
Muscle contraction increases carnitine uptake via translocation of OCTN2.
Furuichi Y, et al. Biochem Biophys Res Commun 418, 774-9 (2012).
Genotype-phenotype correlation in primary carnitine deficiency.
Rose EC, et al. Hum Mutat 33, 118-23 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MFS (cd06174)
  The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
2A0119 (TIGR00898)
  cation transport protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc22a5 includes H.sapiens SLC22A5 and R.norvegicus Slc22a5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (14 transcripts, 9 species)
Liliopsida - monocots (5 transcripts, 4 species)

 

 

 

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