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HomoloGene:811. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SCNN1A,  H.sapiens
sodium channel, non-voltage-gated 1 alpha subunit
    NP_001153047.1
692 aa
   SCNN1A,  P.troglodytes
sodium channel, non-voltage-gated 1 alpha subunit
    XP_508948.4
663 aa
   SCNN1A,  M.mulatta
sodium channel, non-voltage-gated 1 alpha subunit
    XP_001103017.2
692 aa
   SCNN1A,  C.lupus
sodium channel, non-voltage-gated 1 alpha subunit
    XP_005637310.1
713 aa
   SCNN1A,  B.taurus
sodium channel, non-voltage-gated 1 alpha subunit
    NP_777023.1
650 aa
   Scnn1a,  M.musculus
sodium channel, nonvoltage-gated 1 alpha
    NP_035454.2
700 aa
   Scnn1a,  R.norvegicus
sodium channel, nonvoltage-gated 1 alpha
    NP_113736.1
699 aa
   SCNN1A,  G.gallus
sodium channel, non-voltage-gated 1 alpha subunit
    NP_990476.2
637 aa
   scnn1a,  X.tropicalis
sodium channel, non-voltage-gated 1 alpha subunit
    NP_001184124.1
633 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pseudohypoaldosteronism, type I.



Publications
Articles associated with genes and sequences of this homology group.

Genetic variation of SCNN1A influences lung diffusing capacity in cystic fibrosis.
Baker SE, et al. Med Sci Sports Exerc 44, 2315-21 (2012).
[Effects of sodium on rat osteoblast and the role of epithelial sodium channel].
Lu L, et al. Nan Fang Yi Ke Da Xue Xue Bao 31, 1871-4 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ASC (cl02990)
  Amiloride-sensitive sodium channel.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scnn1a includes H.sapiens SCNN1A and R.norvegicus Scnn1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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