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HomoloGene:21252. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLCD1,  H.sapiens
phospholipase C, delta 1
    NP_001124436.1
777 aa
   PLCD1,  P.troglodytes
phospholipase C, delta 1
    XP_003309769.2
913 aa
   PLCD1,  M.mulatta
phospholipase C, delta 1
    XP_001089399.1
777 aa
   PLCD1,  C.lupus
phospholipase C, delta 1
    XP_859460.2
855 aa
   PLCD1,  B.taurus
phospholipase C, delta 1
    NP_001075045.1
756 aa
   Plcd1,  M.musculus
phospholipase C, delta 1
    NP_062650.1
756 aa
   Plcd1,  R.norvegicus
phospholipase C, delta 1
    NP_058731.1
756 aa
   PLCD1,  G.gallus
phospholipase C, delta 1
    XP_418522.2
781 aa
   plcd1,  X.tropicalis
phospholipase C, delta 1
    XP_004915652.1
763 aa
   Os05g0127200,  O.sativa
Os05g0127200
    NP_001054531.1
598 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Intramolecular allosteric interaction in the phospholipase C-δ1 pleckstrin homology domain.
Tanio M & Nishimura K. Biochim Biophys Acta 1834, 1034-43 (2013).
Epigenetic inactivation of PLCD1 in chronic myeloid leukemia.
Song JJ, et al. Int J Mol Med 30, 179-84 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI-PLC-Y (pfam00387)
  Phosphatidylinositol-specific phospholipase C, Y domain.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
PI-PLCc_GDPD_SF (cl14615)
  Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily.
EF-hand_like (cl08538)
  Phosphoinositide-specific phospholipase C, efhand-like.
C2 (cl14603)
  C2 domain.
PI-PLC-Y (cl14781)
  This associates with pfam00388 to form a single structural unit.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plcd1 includes H.sapiens PLCD1 and R.norvegicus Plcd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (13 transcripts, 8 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (6 transcripts, 6 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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