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HomoloGene:20249. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KCNJ2,  H.sapiens
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_000882.1
427 aa
   KCNJ2,  P.troglodytes
potassium inwardly-rectifying channel, subfamily J, member 2
    XP_523701.2
427 aa
   KCNJ2,  M.mulatta
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_001028031.1
427 aa
   KCNJ2,  C.lupus
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_001003120.1
427 aa
   KCNJ2,  B.taurus
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_776798.1
427 aa
   Kcnj2,  M.musculus
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_032451.1
428 aa
   Kcnj2,  R.norvegicus
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_058992.1
427 aa
   KCNJ2,  G.gallus
potassium inwardly-rectifying channel, subfamily J, member 2
    NP_990701.1
427 aa
   kcnj2,  X.tropicalis
potassium inwardly-rectifying channel, subfamily J, member 2
    XP_004916397.1
425 aa
   kcnj2a,  D.rerio
potassium inwardly-rectifying channel, subfamily J, member 2a
    NP_001265731.1
427 aa
   Ir,  D.melanogaster
Inwardly rectifying potassium channel
    NP_651131.2
532 aa
   AgaP_AGAP001280,  A.gambiae
AgaP_AGAP001280
    XP_321870.5
444 aa
   irk-1,  C.elegans
irk-1
    NP_509138.2
544 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Long QT syndrome-7.
Short QT syndrome-3.



Publications
Articles associated with genes and sequences of this homology group.

Energetics and location of phosphoinositide binding in human Kir2.1 channels.
D'Avanzo N, et al. J Biol Chem 288, 16726-37 (2013).
Phenotype variability in patients carrying KCNJ2 mutations.
Kimura H, et al. Circ Cardiovasc Genet 5, 344-53 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IRK_N (pfam08466)
  Inward rectifier potassium channel N-terminal.
IRK (pfam01007)
  Inward rectifier potassium channel.
IRK (pfam01007)
  Inward rectifier potassium channel.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnj2 includes H.sapiens KCNJ2 and R.norvegicus Kcnj2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 4 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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